DE50012871D1 - capillary force - Google Patents

capillary force

Info

Publication number
DE50012871D1
DE50012871D1 DE50012871T DE50012871T DE50012871D1 DE 50012871 D1 DE50012871 D1 DE 50012871D1 DE 50012871 T DE50012871 T DE 50012871T DE 50012871 T DE50012871 T DE 50012871T DE 50012871 D1 DE50012871 D1 DE 50012871D1
Authority
DE
Germany
Prior art keywords
capillary force
capillary
detection area
array
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE50012871T
Other languages
German (de)
Inventor
Robert Seidel
Andreas Wolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micro Biolytics GmbH
Original Assignee
Micro Biolytics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micro Biolytics GmbH filed Critical Micro Biolytics GmbH
Priority to DE50012871T priority Critical patent/DE50012871D1/en
Application granted granted Critical
Publication of DE50012871D1 publication Critical patent/DE50012871D1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3039—Micromixers with mixing achieved by diffusion between layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7172—Feed mechanisms characterised by the means for feeding the components to the mixer using capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Abstract

The invention relates to an analytical microfluid channel array with a high chamber density, on the base of a microtiter plate. Said array is used for analysing chemical, biochemical, biological, physical or other measurable values in separately accommodated liquid samples which are mixed in the analysis chamber. The individual microfluid channel system acts as a capillary force mixer and comprises an inert matrix (1, 2), a detection area (5) and channels (3, 6) which are able to transport liquid in a capillary manner and which interconnect the sample feed openings (4, 7). The capillary liquid transport channel is at least partially formed by the matrix and the detection area. The detection area is suitable e.g., for carrying out analyses using spectrophotometric (e.g., IR) or electrochemical measuring procedures. The invention also relates to the use of said analytical capillary force mixer or test element arrays for determining a measurement in one or more liquids and to a method for determining chemical, biochemical, biological, physical or other measurable values in one or more liquid samples using said capillary force mixer or said microfluid channel array.
DE50012871T 2000-01-21 2000-11-03 capillary force Expired - Fee Related DE50012871D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE50012871T DE50012871D1 (en) 2000-01-21 2000-11-03 capillary force

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10002500A DE10002500A1 (en) 2000-01-21 2000-01-21 Capillary action mixer for mixing components which are analyzed during reaction, e.g. in DNA sequencing, uses capillary action to feed the reactants into the mixer
PCT/EP2000/010869 WO2001052975A1 (en) 2000-01-21 2000-11-03 Capillary force mixer
DE50012871T DE50012871D1 (en) 2000-01-21 2000-11-03 capillary force

Publications (1)

Publication Number Publication Date
DE50012871D1 true DE50012871D1 (en) 2006-07-06

Family

ID=7628262

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10002500A Withdrawn DE10002500A1 (en) 2000-01-21 2000-01-21 Capillary action mixer for mixing components which are analyzed during reaction, e.g. in DNA sequencing, uses capillary action to feed the reactants into the mixer
DE50012871T Expired - Fee Related DE50012871D1 (en) 2000-01-21 2000-11-03 capillary force

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10002500A Withdrawn DE10002500A1 (en) 2000-01-21 2000-01-21 Capillary action mixer for mixing components which are analyzed during reaction, e.g. in DNA sequencing, uses capillary action to feed the reactants into the mixer

Country Status (5)

Country Link
EP (1) EP1251946B1 (en)
AT (1) ATE327820T1 (en)
AU (1) AU2001212785A1 (en)
DE (2) DE10002500A1 (en)
WO (1) WO2001052975A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10251669B3 (en) * 2002-11-06 2004-06-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Capillary substrate for low temperature storage of suspension samples
US20040248306A1 (en) * 2003-06-09 2004-12-09 Hernandez Juan J. Microfluidic water analytical device
CN100392316C (en) * 2006-03-27 2008-06-04 博奥生物有限公司 Flow structure of controlling liquid continuously flowing in micro-pipeline
DE602007011745D1 (en) 2007-07-10 2011-02-17 Roche Diagnostics Gmbh Microfluidic device, mixing method and use of the device
DE102009060626A1 (en) 2009-12-24 2011-06-30 Klapproth, Holger, Dr., 79108 Device for measuring concentration of substances using infrared absorption, has infrared testing unit with inert surface modification or coating that exhibits preset thickness, where coating is applied covalently
EP2718691B1 (en) 2011-06-09 2017-12-13 QFood GmbH Method and apparatus for determining the concentration of an analyte contained in a liquid sample
US8708252B2 (en) 2011-11-28 2014-04-29 Neoperl Gmbh Sanitary installation part

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE399768B (en) * 1975-09-29 1978-02-27 Lilja Jan E CYVETT FOR SAMPLING, MIXING OF, THE SAMPLE WITH A REAGENTS AND DIRECT PERFORMANCE OF, SPECIAL OPTICAL, ANALYSIS OF THE SAMPLE MIXED WITH THE REAGENTS
US4233029A (en) * 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
CA1129498A (en) * 1978-10-25 1982-08-10 Richard L. Columbus Structural configuration and method for transport of a liquid drop through an ingress aperture
GB2097692B (en) * 1981-01-10 1985-05-22 Shaw Stewart P D Combining chemical reagents
US4501496A (en) * 1982-05-07 1985-02-26 Griffin Gladys B Specimen slide for analysis of liquid specimens
US4596695A (en) * 1984-09-10 1986-06-24 Cottingham Hugh V Agglutinographic reaction chamber
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US5104813A (en) * 1989-04-13 1992-04-14 Biotrack, Inc. Dilution and mixing cartridge
DE4403308C2 (en) * 1994-02-03 1997-04-17 Madaus Ag Slides for the examination of liquid samples
DE4405004A1 (en) * 1994-02-17 1995-08-24 Rossendorf Forschzent Chemical micro-analyzer
JP3712007B2 (en) * 1994-12-09 2005-11-02 敬二 大竹 Chemical reaction visual mixing test method
JP3618511B2 (en) * 1997-04-14 2005-02-09 オリンパス株式会社 Microchannel element
US5919711A (en) * 1997-08-07 1999-07-06 Careside, Inc. Analytical cartridge
DE19746581A1 (en) * 1997-10-22 1999-04-29 Merck Patent Gmbh Micro-mixer for mixing liquid, viscous or gaseous phases

Also Published As

Publication number Publication date
ATE327820T1 (en) 2006-06-15
AU2001212785A1 (en) 2001-07-31
EP1251946A1 (en) 2002-10-30
DE10002500A1 (en) 2001-07-26
WO2001052975A1 (en) 2001-07-26
EP1251946B1 (en) 2006-05-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee