DE4406451A1 - Nitrogen supply equipment for e.g. cryomedical probes - Google Patents

Nitrogen supply equipment for e.g. cryomedical probes

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Publication number
DE4406451A1
DE4406451A1 DE19944406451 DE4406451A DE4406451A1 DE 4406451 A1 DE4406451 A1 DE 4406451A1 DE 19944406451 DE19944406451 DE 19944406451 DE 4406451 A DE4406451 A DE 4406451A DE 4406451 A1 DE4406451 A1 DE 4406451A1
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DE
Germany
Prior art keywords
nitrogen
storage container
cryomedical
supply device
nitrogen supply
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19944406451
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German (de)
Other versions
DE4406451C2 (en
Inventor
Bernhardine Dr Rer Na Schumann
Armin Dr Rer Nat Binneberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut fuer Luft und Kaeltetechnik Gemeinnuetzige GmbH
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Institut fuer Luft und Kaeltetechnik Gemeinnuetzige GmbH
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Priority to DE19944406451 priority Critical patent/DE4406451C2/en
Publication of DE4406451A1 publication Critical patent/DE4406451A1/en
Application granted granted Critical
Publication of DE4406451C2 publication Critical patent/DE4406451C2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C9/00—Methods or apparatus for discharging liquefied or solidified gases from vessels not under pressure
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2201/00—Vessel construction, in particular geometry, arrangement or size
    • F17C2201/01—Shape
    • F17C2201/0104—Shape cylindrical
    • F17C2201/0119—Shape cylindrical with flat end-piece
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2203/00—Vessel construction, in particular walls or details thereof
    • F17C2203/03—Thermal insulations
    • F17C2203/0391—Thermal insulations by vacuum
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
    • F17C2205/03—Fluid connections, filters, valves, closure means or other attachments
    • F17C2205/0302—Fittings, valves, filters, or components in connection with the gas storage device
    • F17C2205/0323—Valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2221/00—Handled fluid, in particular type of fluid
    • F17C2221/01—Pure fluids
    • F17C2221/014—Nitrogen
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2223/00—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel
    • F17C2223/01—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel characterised by the phase
    • F17C2223/0146—Two-phase
    • F17C2223/0153—Liquefied gas, e.g. LPG, GPL
    • F17C2223/0161—Liquefied gas, e.g. LPG, GPL cryogenic, e.g. LNG, GNL, PLNG
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
    • F17C2227/01—Propulsion of the fluid
    • F17C2227/0128—Propulsion of the fluid with pumps or compressors
    • F17C2227/0135—Pumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
    • F17C2227/03—Heat exchange with the fluid
    • F17C2227/0302—Heat exchange with the fluid by heating
    • F17C2227/0304—Heat exchange with the fluid by heating using an electric heater
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2250/00—Accessories; Control means; Indicating, measuring or monitoring of parameters
    • F17C2250/04—Indicating or measuring of parameters as input values
    • F17C2250/0404—Parameters indicated or measured
    • F17C2250/0408—Level of content in the vessel
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2250/00—Accessories; Control means; Indicating, measuring or monitoring of parameters
    • F17C2250/06—Controlling or regulating of parameters as output values
    • F17C2250/0605—Parameters
    • F17C2250/0626—Pressure
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2270/00—Applications
    • F17C2270/02—Applications for medical applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Compressors, Vaccum Pumps And Other Relevant Systems (AREA)

Abstract

The nitrogen storage container (1) is constructed as a pressure vessel provided with a multi-layered vacuum insulation (2). In the nitrogen storage container (1) is an electric heater (3), regulated by the internal pressure. In the lower part is a connection point (4) with a time-controlled magnetic valve (5) for the removal of liquid nitrogen. There may be an electronic gauge showing the among of liquid nitrogen contained.

Description

Die Erfindung betrifft ein Stickstoffversorgungsgerät für kryomedizinische Zwecke insbesondere für die Versorgung von kryomedizinischen Sonden mit flüssigem Stickstoff (LN₂).The invention relates in particular to a nitrogen supply device for cryomedical purposes for the supply of cryomedical probes with liquid nitrogen (LN₂).

Bekannt ist ein kryomedizinisches Handgerät für Spray- und Contactfreezing, das einen Vorratsbehälter für den Stickstoff und ein Mehrwegeventil zur Regulierung des Druckes und zur Entnahme des flüssigen Stickstoffs besitzt. Der Druckaufbau im Vorratsbehälter zur Entnahme des flüssigen Stickstoffs erfolgt durch Verdampfung infolge der Außentemperatur, d. h. der Raumtemperatur, am Vorratsbehälter. An dem Vorratsbehälter ist ein Handgriff mit einem Bedienungshebel für das Mehrwegeventil angeordnet.A cryomedical hand-held device for spray and contact freezing is known Storage tank for the nitrogen and a multi-way valve for regulating the pressure and for Removal of the liquid nitrogen possesses. The pressure build-up in the storage container for removal the liquid nitrogen occurs through evaporation due to the outside temperature, d. H. of the Room temperature, at the storage container. On the storage container is a handle with one Operating lever arranged for the multi-way valve.

Nachteilig an diesem Gerät ist der geringe Bedienungskomfort hinsichtlich der Druckregulierung und damit der Anpassung der Stickstoff-Menge an den jeweiligen Anwendungsfall. Ein weiterer Nachteil besteht darin, daß es am Vorratsbehälter zu Reifansatz kommt, da eine dies verhindernde Isolierung nicht möglich ist, denn die Umgebungstemperatur wird zum Druckaufbau durch Verdampfung des Stickstoffes benötigt.The disadvantage of this device is the low ease of use with regard to pressure regulation and thus the adjustment of the amount of nitrogen to the respective application. Another The disadvantage is that there is ripening on the storage container, since this is one preventive insulation is not possible because the ambient temperature becomes Pressure build-up required by evaporation of the nitrogen.

In der DE-OS 41 07 320 wird eine Vorrichtung zum kontinuierlichen Nachfüllen von Flüssigstickstoff in Kühlkammern vorgeschlagen. In Abhängigkeit vom Füllstand in der Kühlkammer wird mittels eines Heizelementes im Vorratsbehälter der Fülldruck erzeugt, so daß flüssiger Stickstoff in die Kühlkammer nachfließt. Der Füllstand kann mit Sensoren überwacht werden, die über eine Regeleinrichtung das Heizelement zu- bzw. abschalten. Der Vorratsbehälter besitzt ein Drosselorgan, das den laufend ohne zusätzliche Wärmezufuhr abdampfenden Stickstoff entweichen läßt. Auch diese Vorrichtung ist nicht geeignet, eine zuverlässige Versorgung von kryomedizinischen Sonden zu gewährleisten.DE-OS 41 07 320 describes a device for the continuous refilling of Liquid nitrogen in cooling chambers proposed. Depending on the level in the Cooling chamber is generated by means of a heating element in the reservoir, the filling pressure, so that liquid nitrogen flows into the cooling chamber. The level can be monitored with sensors that switch the heating element on or off via a control device. The reservoir has a throttling device that continuously evaporates without additional heat Let nitrogen escape. This device is also not suitable for being reliable Ensure supply of cryomedical probes.

Aufgabe der Erfindung ist es, ein Stickstoffversorgungsgerät für kryomedizinische Zwecke zu schaffen, das eine gute Beaufschlagung der kryomedizinischen Sonden mit Stickstoff ermöglicht und das von Personal bedient werden kann, das keine speziellen technischen Kenntnisse auf dem Gebiet der Kryotechnik besitzt.The object of the invention is to provide a nitrogen supply device for cryomedical purposes create that allows a good exposure of the cryomedical probes with nitrogen and that can be operated by personnel who have no special technical knowledge on the Owns the field of cryogenics.

Erfindungsgemäß wird die Aufgabe durch die Merkmale der Patentansprüche gelöst. Mit dem Gerät ist es möglich, die Dauer und Intensität der kryomedizinischen Behandlung bei einfacher Handhabung genau und reproduzierbar einzustellen. Durch die Vakuumvielschichtisolation in Verbindung mit der Kryopumpe wird erreicht, daß es zu keinen nennenswerten Stickstoffverlusten kommt und der Vorratsbehälter nicht vereist bzw. kondensierte Luftfeuchte von der Außenwand des Versorgungsgerätes abtropft.According to the invention the object is achieved by the features of the claims. With the It is possible to simplify the duration and intensity of cryomedical treatment Adjust handling precisely and reproducibly. Due to the vacuum multilayer insulation in Connection with the cryopump ensures that there are no noteworthy Nitrogen loss occurs and the storage container does not ice up or condensed air humidity drips from the outer wall of the supply unit.

Die Erfindung wird nachfolgend an einem Ausführungsbeispiel erläutert. Die Abbildung zeigt das erfindungsgemäße Stickstoffversorgungsgerät mit dem dazugehörigen Steuergerät als schematische Darstellung.The invention is explained below using an exemplary embodiment. The illustration shows that Nitrogen supply device according to the invention with the associated control device as schematic representation.

In dem Gehäuse 7 befindet sich der Stickstoffvorratsbehälter 1 der gegenüber dem Gehäuse 7 mit einer Vakuumvielschichtisolation 2 versehen ist. Damit wird eine Beeinflussung des Stickstoffvorratsbehälters 1 durch die Raumtemperatur nahezu ausgeschlossen. Im unteren Teil des Stickstoffvorratsbehälters 1 ist eine elektrische Heizung 3 angeordnet, die in Abhängigkeit vom Innendruck geregelt wird. Als vorteilhaft hat sich ein Innendruck von 0,4 MPa erwiesen. Das maximale Fassungsvermögen beträgt beispielsweise 1 l. Der Füllstand wird mit Temperatursensoren 10 überwacht und kann am Steuergerät 12 mit einer LN₂-Standanzeige 16, die z. B. mit Leuchtdioden arbeitet, kontrolliert werden.In the housing 7, the nitrogen storage vessel 1 is provided relative to the housing 7 with a vacuum multilayer insulation 2 is located. An influence on the nitrogen storage container 1 by the room temperature is thus almost impossible. In the lower part of the nitrogen storage container 1 , an electric heater 3 is arranged, which is regulated depending on the internal pressure. An internal pressure of 0.4 MPa has proven to be advantageous. The maximum capacity is 1 l, for example. The level is monitored with temperature sensors 10 and can be on the control unit 12 with an LN₂ level indicator 16 , the z. B. works with LEDs, be checked.

Aus Sicherheitsgründen werden am Gehäuse 7 und dem Stickstoffvorratsbehälter 1 Berstscheiben 9 angeordnet. Außerdem besitzt der Stickstoffvorratsbehälter 1 ein Überdrucksicherheitsventil 8, in das ein LN₂-Füllstutzen integriert ist. For safety reasons, rupture disks 9 are arranged on the housing 7 and the nitrogen storage container 1 . In addition, the nitrogen reservoir 1 has an overpressure safety valve 8 , in which an LN₂ filler neck is integrated.

Um zu erreichen, daß das Isolationsvakuum mindestens 1 Jahr aufrechterhalten wird, ist in der Vakuumvielschichtisolation 2 eine Kryopumpe 6 angeordnet. Zur Herstellung des Isolationsvakuums mittels einer Vakuumpumpe ist am Gehäuse 7 ein Vakuumanschlußstutzen 11 mit einem Verschlußventil angebracht.In order to ensure that the insulation vacuum is maintained for at least 1 year, a cryopump 6 is arranged in the vacuum multilayer insulation 2 . To produce the insulation vacuum by means of a vacuum pump, a vacuum connecting piece 11 with a closure valve is attached to the housing 7 .

Im unteren Bereich des Stickstoffvorratsbehälters befindet sich der LN₂-Anschlußstutzen 4 mit einem Magnetventil 5 zur Entnahme des flüssigen Stickstoffes.In the lower area of the nitrogen reservoir there is the LN₂ connection 4 with a solenoid valve 5 for removing the liquid nitrogen.

Die Handhabung des erfindungsgemäßen Gerätes ist denkbar einfach. Entsprechend der notwendigen Therapie wird am Zeitschaltwerk 13 die Behandlungszeit eingestellt und mit dem Startschalter 14 das Magnetventil 5 geöffnet. Nach Ablauf der eingestellten Zeit schließt das Magnetventil 5 selbständig. Bei Druckabfall im Stickstoffvorratsbehälter 1 wird die elektrische Heizung 3 automatisch zugeschaltet, bis der erforderliche Arbeitsdruck erreicht ist. Am Steuergerät ist zusätzlich eine Druckanzeige 17 für Kontrollzwecke vorgesehen.The handling of the device according to the invention is very simple. In accordance with the necessary therapy, the treatment time is set on the time switch 13 and the solenoid valve 5 is opened with the start switch 14 . After the set time, the solenoid valve 5 closes automatically. If the pressure in the nitrogen storage container 1 drops, the electric heater 3 is automatically switched on until the required working pressure is reached. A pressure indicator 17 is also provided on the control unit for control purposes.

Über einen Notschalter 15 kann das Magnetventil 5 jederzeit bei Bedarf geschlossen werden.The solenoid valve 5 can be closed at any time via an emergency switch 15 if required.

BezugszeichenlisteReference list

1 Stickstoffvorratsbehälter
2 Vakuumvielschichtisolation
3 elektrische Heizung
4 LN₂-Anschlußstutzen
5 Magnetventil
6 Kryopumpe
7 Gehäuse
8 Überdrucksicherheitsventil
9 Berstscheibe
10 Temperatur-Sensoren
11 Vakuumanschlußstutzen
12 Steuergerät
13 Zeitschaltwerk
14 Startschalter
15 Notschalter
16 LN₂-Standanzeige
17 Druckanzeige 1 nitrogen storage container
2 vacuum multilayer insulation
3 electric heating
4 LN₂ connecting pieces
5 solenoid valve
6 cryopump
7 housing
8 overpressure safety valve
9 rupture disc
10 temperature sensors
11 vacuum connector
12 control unit
13 timer
14 start switch
15 emergency switches
16 LN₂ level indicator
17 pressure display

Claims (5)

1. Stickstoffversorgungsgerät für kryomedizinische Zwecke, insbesondere zur Versorgung kryomedizinischer Sonden, das mit einem Stickstoff­ vorratsbehälter ausgestattet ist, dadurch gekennzeichnet, daß der Stickstoffvorratsbehälter (1) als Druckbehälter ausgebildet und mit einer Vakuumvielschichtisolation (2) versehen ist und daß in dem Stickstoff­ vorratsbehälter (1) eine vom Innendruck abhängige, geregelte elektrische Heizung (3) angebracht ist und daß sich im unteren Teil ein Anschlußstutzen (4) mit einem zeitgesteuerten Magnetventil (5) für die Entnahme von flüssigen Stickstoff befindet.1. Nitrogen supply device for cryomedical purposes, in particular for supplying cryomedical probes, which is equipped with a nitrogen storage container, characterized in that the nitrogen storage container ( 1 ) is designed as a pressure container and is provided with a vacuum multilayer insulation ( 2 ) and in that the nitrogen storage container ( 1 ) a controlled electric heater ( 3 ) depending on the internal pressure is attached and that there is a connection piece ( 4 ) with a time-controlled solenoid valve ( 5 ) for the removal of liquid nitrogen in the lower part. 2. Stickstoffversorgungsgerät nach Anspruch 1, dadurch gekennzeichnet, daß die geregelte elektrische Heizung (3) auf einen Innendruck von ca. 0,4 MPa eingestellt ist.2. Nitrogen supply device according to claim 1, characterized in that the regulated electrical heater ( 3 ) is set to an internal pressure of approximately 0.4 MPa. 3. Stickstoffversorgungsgerät nach Anspruch 1, dadurch gekennzeichnet, daß eine elektronische Füllstandsanzeige für den flüssigen Stickstoff vorhanden ist.3. Nitrogen supply device according to claim 1, characterized in that An electronic level indicator for the liquid nitrogen is available is. 4. Stickstoffversorgungsgerät nach Anspruch 1, dadurch gekennzeichnet, daß die Öffnungszeit des Magnetventils (5) stufenlos zwischen 0 s und 300 s einstellbar ist und daß das Magnetventil (5) durch einen Notschalter (15) geschlossen werden kann.4. Nitrogen supply device according to claim 1, characterized in that the opening time of the solenoid valve ( 5 ) is continuously adjustable between 0 s and 300 s and that the solenoid valve ( 5 ) can be closed by an emergency switch ( 15 ). 5. Stickstoffversorgungsgerät nach Anspruch 1, dadurch gekennzeichnet, daß mittels einer in der Vakuumvielschichtisolation (2) angeordneten Kryopumpe (6) das Isolationsvakuum mindestens 1 Jahr aufrechterhalten wird.5. Nitrogen supply device according to claim 1, characterized in that by means of a in the vacuum multilayer insulation ( 2 ) arranged cryopump ( 6 ), the insulation vacuum is maintained for at least 1 year.
DE19944406451 1994-02-28 1994-02-28 Nitrogen supply device for cryomedical purposes Expired - Lifetime DE4406451C2 (en)

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Application Number Priority Date Filing Date Title
DE19944406451 DE4406451C2 (en) 1994-02-28 1994-02-28 Nitrogen supply device for cryomedical purposes

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Application Number Priority Date Filing Date Title
DE19944406451 DE4406451C2 (en) 1994-02-28 1994-02-28 Nitrogen supply device for cryomedical purposes

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DE4406451A1 true DE4406451A1 (en) 1995-09-07
DE4406451C2 DE4406451C2 (en) 1996-09-05

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012058158A1 (en) * 2010-10-26 2012-05-03 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9872718B2 (en) 2012-04-27 2018-01-23 Medtronic Adrian Luxembourg S.a.r.l. Shafts with pressure relief in cryotherapeutic catheters and associated devices, systems, and methods
US10004550B2 (en) 2010-08-05 2018-06-26 Medtronic Ardian Luxembourg S.A.R.L. Cryoablation apparatuses, systems, and methods for renal neuromodulation
US10492842B2 (en) 2014-03-07 2019-12-03 Medtronic Ardian Luxembourg S.A.R.L. Monitoring and controlling internally administered cryotherapy
US10588682B2 (en) 2011-04-25 2020-03-17 Medtronic Ardian Luxembourg S.A.R.L. Apparatus and methods related to constrained deployment of cryogenic balloons for limited cryogenic ablation of vessel walls
US10905490B2 (en) 2012-04-27 2021-02-02 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices for renal neuromodulation and associated systems and methods

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US9060754B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9095321B2 (en) 2012-11-21 2015-08-04 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices having integral multi-helical balloons and methods of making the same
US9017317B2 (en) 2012-12-06 2015-04-28 Medtronic Ardian Luxembourg S.A.R.L. Refrigerant supply system for cryotherapy including refrigerant recompression and associated devices, systems, and methods

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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10004550B2 (en) 2010-08-05 2018-06-26 Medtronic Ardian Luxembourg S.A.R.L. Cryoablation apparatuses, systems, and methods for renal neuromodulation
WO2012058158A1 (en) * 2010-10-26 2012-05-03 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US10188445B2 (en) 2010-10-26 2019-01-29 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US10842547B2 (en) 2010-10-26 2020-11-24 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
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US11751931B2 (en) 2012-04-27 2023-09-12 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices for renal neuromodulation and associated systems and methods
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