DE427669C - Process for the preparation of a colloidal, water-soluble bismuth for injection purposes - Google Patents

Process for the preparation of a colloidal, water-soluble bismuth for injection purposes

Info

Publication number
DE427669C
DE427669C DEM79423D DEM0079423D DE427669C DE 427669 C DE427669 C DE 427669C DE M79423 D DEM79423 D DE M79423D DE M0079423 D DEM0079423 D DE M0079423D DE 427669 C DE427669 C DE 427669C
Authority
DE
Germany
Prior art keywords
water
colloidal
preparation
bismuth
injection purposes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEM79423D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck KGaA
Original Assignee
E Merck AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E Merck AG filed Critical E Merck AG
Priority to DEM79423D priority Critical patent/DE427669C/en
Application granted granted Critical
Publication of DE427669C publication Critical patent/DE427669C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Darstellung eines kolloidalen, in Wasser löslichen Wismutes für Injektionszwecke. Die Verwendung unlöslicher Wismutverbindungen für Injektionszwecke birgt wegen der Bildung langfristiger Depots Gefahren in sich. Molekular lösliche Wismutpräparate besitzen entweder stark saure oder alkalische Reaktion und üben daher, selbst in Ölemulsionen, Ätzwirkungen auf lebendes Gewebe aus. Um die beiden genannten Übelstände zu vermeiden, wurde die Gewinnung eines kolloidalen Wismutes erstrebt. Es zeigte sich jedoch dabei, daß es recht schwer ist, ein haltbares Präparat herzustellen. Hierauf ist wahrscheinlich das Versagen des kolloidalen Wismutes bei früheren therapeutischen Versuchen zurückzuführen.Process for the preparation of a colloidal, water-soluble bismuth for injections. The use of insoluble bismuth compounds for injections poses dangers due to the formation of long-term deposits. Molecularly soluble Bismuth preparations have either a strongly acidic or alkaline reaction and practice therefore, even in oil emulsions, corrosive effects on living tissue. To both of them In order to avoid the above-mentioned problems, a colloidal bismuth was obtained strives. It turned out, however, that it is quite difficult to find a durable preparation to manufacture. This is probably due to the failure of the colloidal bismuth attributed to previous therapeutic attempts.

Es wurde nun gefunden, daß es gelingt, ein in Gelform haltbares, in Wasser lösliches Wismutkolloid herzustellen, wenn man alkalische Wismutlösungen unter Ausschluß von Luft in Gegenwart von Schutzkolloiden und unter Vermeidung hoher Temperaturen mit Natriumhydrosulfitlösung reduziert, das Kolloid durch Alkohol oder ähnliche Fällungsmittel ausfällt und vorsichtig trocknet.It has now been found that it is possible to obtain a stable in gel form, in Water-soluble bismuth colloid can be produced when using alkaline bismuth solutions with the exclusion of air in the presence of protective colloids and avoiding high Temperatures reduced with sodium hydrosulfite solution, the colloid with alcohol or similar precipitant precipitates and carefully dries.

Beispiel. 400 g Seignettsalz wurden in 2 1 Wasser und igo ccm Natronlauge (i,34) gelöst und Zoo g Bismutum subnitricum allmählich unter Erwärmen hinzugefügt. Wenn Lösung eingetreten ist, setzt man noch ','21 Wasser hinzu. Von dieser Vorratslösung bereitet man sich eine größere= Menge. 218o ccm dieser Wismutlösung und x32o ccm einer g prozentigen Gummilösung wurden zusammen mit 75 ccm Natronlauge (i,34) in eine 7-Liter- Flasche geschüttet und eine Lösung von 365 ccm Natriumhydrosulfit in 3400 ccm Wasser hinzugegeben. Alle Lösungen müssen klar filtriert sein. Die Flasche wird verschlossen und z Stunde langsam geschüttelt. Das so erhaltene Sol ist tagelang an der Luft haltbar. Zur Überführung in die Gelform gießt man es in einen Stutzen und fügt unterRühren 6450 ccm 87 prozentigen Alkohol hinzu. Das Gel wird mit 58prozentigem Alkohol viermal ausgewaschen, um es von den mitgerissenen Salzen zu befreien, und dann zum Trccknen auf Glasplatten gestrichen. Es enthält etwa 40 Prozent Wismut, etwa 44Prozent organische Substanzen und ist wasserlöslich.Example. 400 g of Seignett salt were dissolved in 2 liters of water and igo cc of sodium hydroxide solution (i, 34) dissolved and zoo g of Bismutum subnitricum gradually added with heating. When solution has occurred, one adds', '21 water. From this stock solution if you prepare a larger = amount. 218o cc of this bismuth solution and x32o cc a g percent rubber solution together with 75 ccm sodium hydroxide solution (i, 34) in poured a 7 liter bottle and a solution of 365 cc sodium hydrosulfite added in 3400 cc of water. All solutions must be filtered clear. The bottle is closed and shaken slowly for an hour. The sol obtained in this way lasts for days can be kept in the air. To transfer it into the gel form, it is poured into a nozzle and adds 6450 cc of 87 percent alcohol while stirring. The gel is made with 58 percent Alcohol washed out four times to rid it of the entrained salts, and then painted on glass plates to dry. It contains about 40 percent bismuth, about 44 percent organic substances and is water soluble.

Claims (1)

PATEN T-ANSPRUcH: Verfahren zur Darstellung eines kolloidalen, in Wasser löslichen Wismutes für Injektionszwecke, dadurch gekennzeichnet, daß man eine alkalische Wismutlösung unter Ausschluß derLuft inGegenwart vonSchutzkolloiden und unter Vermeidung hoher Temperatur mit Natriumhydrosulfitlösung reduziert, das Kolloid durch Alkohol oder ähnliche Fällungsmittel ausfällt und vorsichtig trocknet.PATEN T CLAIM: Process for the preparation of a colloidal, in Water-soluble bismuth for injection purposes, characterized in that one an alkaline bismuth solution in the absence of air in the presence of protective colloids and while avoiding high temperature with sodium hydrosulfite solution, the Colloid precipitates from alcohol or similar precipitants and carefully dries.
DEM79423D 1922-10-27 1922-10-27 Process for the preparation of a colloidal, water-soluble bismuth for injection purposes Expired DE427669C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEM79423D DE427669C (en) 1922-10-27 1922-10-27 Process for the preparation of a colloidal, water-soluble bismuth for injection purposes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEM79423D DE427669C (en) 1922-10-27 1922-10-27 Process for the preparation of a colloidal, water-soluble bismuth for injection purposes

Publications (1)

Publication Number Publication Date
DE427669C true DE427669C (en) 1926-04-14

Family

ID=7318406

Family Applications (1)

Application Number Title Priority Date Filing Date
DEM79423D Expired DE427669C (en) 1922-10-27 1922-10-27 Process for the preparation of a colloidal, water-soluble bismuth for injection purposes

Country Status (1)

Country Link
DE (1) DE427669C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0276674A1 (en) * 1987-01-24 1988-08-03 Bayer Ag Parenteral solution

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0276674A1 (en) * 1987-01-24 1988-08-03 Bayer Ag Parenteral solution
US4842856A (en) * 1987-01-24 1989-06-27 Bayer Aktiengesellschaft Parenteral solution

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