DE511303C - Process for the preparation of disodium salts of 4-iminomethylene-sulfuric acid-2-metal-mercaptobenzene-1-sulphonic acid - Google Patents

Process for the preparation of disodium salts of 4-iminomethylene-sulfuric acid-2-metal-mercaptobenzene-1-sulphonic acid

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Publication number
DE511303C
DE511303C DEC37633D DEC0037633D DE511303C DE 511303 C DE511303 C DE 511303C DE C37633 D DEC37633 D DE C37633D DE C0037633 D DEC0037633 D DE C0037633D DE 511303 C DE511303 C DE 511303C
Authority
DE
Germany
Prior art keywords
mercaptobenzene
metal
iminomethylene
acid
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEC37633D
Other languages
German (de)
Inventor
Dr Erich Borgwardt
Dr Adolf Feldt
Dr Walter Schoeller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schering Kahlbaum AG
Original Assignee
Schering Kahlbaum AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Kahlbaum AG filed Critical Schering Kahlbaum AG
Priority to DEC37633D priority Critical patent/DE511303C/en
Application granted granted Critical
Publication of DE511303C publication Critical patent/DE511303C/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

Verfahren zur Darstellung von Dinatriumsalzen der 4-Iminomethylenschwefligen Säure-2-metallmercaptobenzol-i-sulfosäuren Läßt man auf die in der amerikanischen Patentschrift i 633 626 und der britischen Patentschrift 266824 beschriebenen 4-amino-2-metallmercaptobenzol-i-sulfosäuren Formaldehydbisulfite (oxymethansulfonsaure Salze), zweckmäßig bei erhöhter Temperatur, einwirken, so gelangt man zu Verbindungen, die sich durch erhöhte therapeutische Wirksamkeit, Ungiftigkeit und Haltbarkeit vor den Ausgangsstoffen auszeichnen.Process for the preparation of disodium salts of 4-iminomethylene-sulphonic acid-2-metal-mercaptobenzene-i-sulphonic acids leaves the 4-amino-2-metal-mercaptobenzene-i-sulphonic acid formaldehyde bisulphites (oxymethanesulphonic acid salts) described in American patent 1,633,626 and British patent 2,66824 ), expediently at elevated temperature, this leads to compounds that are characterized by increased therapeutic effectiveness, non-toxicity and durability compared to the starting materials.

Die neuen Verbindungen sind schwach gefärbte Stoffe, die sich in Wasser mit größter Leichtigkeit lösen und aus diesen Lösungen durch Alkohol gefällt werden.The new compounds are faintly colored substances that are in water dissolve with the greatest ease and be precipitated from these solutions by alcohol.

Beispiel i Man löst 42,3 Teile 4-amino-2-auromercaptobenzol-i-sulfosaures Natrium in 2oo Teilen Wasser, fügt 13 Teile formaldehydschwefligsaures Natrium zu und erhitzt die Lösung unter Rühren zum Sieden. Man läßt erkalten und fällt die gebildete N-Formaldehydbisulfitverbindung mit Alkohol. Die Verbindung ist hellgelb gefärbt, in Wasser leicht löslich und hat einen Goldgehalt von 36%. Beispiele 33.4 Teile 4-amino-2-argentomercaptobenzol-i-sulfosaures Natrium werden in 15o Teilen Wasser gelöst, 14 Teile formaldehydschwefligsaures Natrium hinzugefügt und die Lösung unter Rühren zum Sieden erhitzt. Nach dem Erkalten wird die gebildete N-Formaldehydbisulfitverbindung mit Alkohol gefällt.Example i 42.3 parts of 4-amino-2-auromercaptobenzene-i-sulfosaures are dissolved Sodium in 200 parts of water adds 13 parts of sodium formaldehyde-sulfuric acid and heats the solution to boiling while stirring. You let it cool down and fall formed N-formaldehyde bisulfite compound with alcohol. The connection is light yellow colored, easily soluble in water and has a gold content of 36%. Examples 33.4 Parts of 4-amino-2-argentomercaptobenzene-i-sulfosauresodium are in 150 parts Dissolved water, 14 parts of sodium formaldehyde-sulfuric acid added and the solution heated to boiling with stirring. After cooling, the N-formaldehyde bisulfite compound formed is like with alcohol.

Das Dinatriumsalz der 4-Iminomethylensch,#refligen Säure- 2-argentomercaptobenzoli-sulfosäure ist ein lichtgelbes, in Wasser sehr leicht lösliches Pulver mit einem Silbergehalt von 24 %.The disodium salt of 4-iminomethylene, # refligen acid-2-argentomercaptobenzoli-sulfonic acid is a light yellow, very easily soluble in water powder with a silver content of 24%.

Beispiel 3 Man löst 29,5 Teile 4-amino-2-bismutomercaptobenzol-i-sulfosaures Natrium in 15 o Teillen Wasser, fügt 14 Teile formaldehydschw efligsaur es Natrium hinzu und erhitzt zum Sieden. Die klare rotbraune Lösung wird nach dem Erkalten mit Alkohol gefällt und so die 4, w-Sulfomethylaminoverbindung als leicht wasserlösliches, orangegelbes Pulver mit einem Wismutgehalt von 16, 5 % erhalten.Example 3 Dissolve 29.5 parts of 4-amino-2-bismutomercaptobenzol-i-sulfosaures sodium in 1 5 o Teillen water, add 14 parts efligsaur formaldehydschw there sodium are added and heated to boiling. After cooling, the clear red-brown solution is precipitated with alcohol and the 4, w-sulfomethylamino compound is obtained as a readily water-soluble, orange-yellow powder with a bismuth content of 16.5%.

Claims (1)

PFAATENTÄNSPRUC,H: Ver-ähren-- -zur Djstellung von Di- natriunasalzen der ¢-Iminomethylenschwef- ligen Säure-2-metallmercaptobenzol-i-sul- fosäuren (¢, cü-Sulfomethylamino-2-metall-
mercaptobenzol - r - sulfosäuren), dadurch gekennzeichnet, daß man Formaldehydbisulfite (oxymethansulfonsaure Salze) auf die Natriumsalze der ¢-Amino-2-metallmercaptobenzol-i-sulfosäuren, zweckmäßig bei erhöhter Temperatur, einwirken läßt. PFAATENTÄNSPRUC, H: Ver-hren-- -for the provision of di- sodium salts of the ¢ -iminomethylene sulfur acid-2-metal mercaptobenzene-i-sul- fic acids (¢, cü-sulfomethylamino-2-metal-
mercaptobenzene-r-sulfonic acids), characterized in that formaldehyde bisulfites (oxymethanesulfonic acid salts) are allowed to act on the sodium salts of [-amino-2-metal mercaptobenzene-1-sulfonic acids, expediently at elevated temperature.
DEC37633D 1925-12-13 1925-12-13 Process for the preparation of disodium salts of 4-iminomethylene-sulfuric acid-2-metal-mercaptobenzene-1-sulphonic acid Expired DE511303C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEC37633D DE511303C (en) 1925-12-13 1925-12-13 Process for the preparation of disodium salts of 4-iminomethylene-sulfuric acid-2-metal-mercaptobenzene-1-sulphonic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEC37633D DE511303C (en) 1925-12-13 1925-12-13 Process for the preparation of disodium salts of 4-iminomethylene-sulfuric acid-2-metal-mercaptobenzene-1-sulphonic acid

Publications (1)

Publication Number Publication Date
DE511303C true DE511303C (en) 1930-10-30

Family

ID=7022910

Family Applications (1)

Application Number Title Priority Date Filing Date
DEC37633D Expired DE511303C (en) 1925-12-13 1925-12-13 Process for the preparation of disodium salts of 4-iminomethylene-sulfuric acid-2-metal-mercaptobenzene-1-sulphonic acid

Country Status (1)

Country Link
DE (1) DE511303C (en)

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