DE3940052C2 - - Google Patents
Info
- Publication number
- DE3940052C2 DE3940052C2 DE3940052A DE3940052A DE3940052C2 DE 3940052 C2 DE3940052 C2 DE 3940052C2 DE 3940052 A DE3940052 A DE 3940052A DE 3940052 A DE3940052 A DE 3940052A DE 3940052 C2 DE3940052 C2 DE 3940052C2
- Authority
- DE
- Germany
- Prior art keywords
- alpha
- mmol
- weight
- methyl
- solution according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- LKDRXBCSQODPBY-ZXXMMSQZSA-N alpha-D-fructopyranose Chemical compound OC[C@]1(O)OC[C@@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-ZXXMMSQZSA-N 0.000 description 1
- HWXBTNAVRSUOJR-UHFFFAOYSA-N alpha-hydroxyglutaric acid Natural products OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 description 1
- 229940009533 alpha-ketoglutaric acid Drugs 0.000 description 1
- 238000005576 amination reaction Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 230000008238 biochemical pathway Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 150000005693 branched-chain amino acids Chemical class 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000003841 chloride salts Chemical class 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 201000007025 diabetic cataract Diseases 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 229940105423 erythropoietin Drugs 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000023266 generation of precursor metabolites and energy Effects 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 description 1
- 201000008980 hyperinsulinism Diseases 0.000 description 1
- 230000002727 hyperosmolar Effects 0.000 description 1
- 230000007124 immune defense Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- ODBLHEXUDAPZAU-UHFFFAOYSA-N isocitric acid Chemical compound OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 210000000885 nephron Anatomy 0.000 description 1
- 231100001093 no immunotoxicity Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- 239000003330 peritoneal dialysis fluid Substances 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000005891 transamination reaction Methods 0.000 description 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/287—Dialysates therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3940052A DE3940052A1 (de) | 1989-12-04 | 1989-12-04 | Dialysier- und spuelloesung zur intraperitonealen verabreichung |
| EP90122823A EP0431465B1 (de) | 1989-12-04 | 1990-11-29 | Dialysier- und Spüllösung zur intraperitonealen Verarbreichung |
| DK90122823.9T DK0431465T3 (da) | 1989-12-04 | 1990-11-29 | Vandig dialyse- og skylleopløsning |
| DE59005355T DE59005355D1 (de) | 1989-12-04 | 1990-11-29 | Dialysier- und Spüllösung zur intraperitonealen Verarbreichung. |
| AT90122823T ATE104149T1 (de) | 1989-12-04 | 1990-11-29 | Dialysier- und spuelloesung zur intraperitonealen verarbreichung. |
| ES90122823T ES2054200T3 (es) | 1989-12-04 | 1990-11-29 | Solucion de dialisis y lavado para la administracion por via intraperitoneal. |
| PCT/EP1990/002078 WO1991008009A1 (de) | 1989-12-04 | 1990-12-03 | Dialysier- und spüllösung zur intraperitonealen verabreichung |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3940052A DE3940052A1 (de) | 1989-12-04 | 1989-12-04 | Dialysier- und spuelloesung zur intraperitonealen verabreichung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3940052A1 DE3940052A1 (de) | 1991-06-06 |
| DE3940052C2 true DE3940052C2 (enExample) | 1991-12-05 |
Family
ID=6394774
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3940052A Granted DE3940052A1 (de) | 1989-12-04 | 1989-12-04 | Dialysier- und spuelloesung zur intraperitonealen verabreichung |
| DE59005355T Expired - Fee Related DE59005355D1 (de) | 1989-12-04 | 1990-11-29 | Dialysier- und Spüllösung zur intraperitonealen Verarbreichung. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59005355T Expired - Fee Related DE59005355D1 (de) | 1989-12-04 | 1990-11-29 | Dialysier- und Spüllösung zur intraperitonealen Verarbreichung. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0431465B1 (enExample) |
| AT (1) | ATE104149T1 (enExample) |
| DE (2) | DE3940052A1 (enExample) |
| DK (1) | DK0431465T3 (enExample) |
| ES (1) | ES2054200T3 (enExample) |
| WO (1) | WO1991008009A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6380163B1 (en) * | 1992-12-22 | 2002-04-30 | Baxter International Inc. | Peritoneal dialysis solutions with polypeptides |
| IT1263967B (it) * | 1993-02-24 | 1996-09-05 | Soluzioni per dialisi peritoneale | |
| CA2155910C (en) * | 1995-08-11 | 1999-12-14 | George Wu | Biocompatible aqueous solution for use in continuous ambulatory peritoneal dialysis |
| US5716926A (en) * | 1996-07-26 | 1998-02-10 | Paxton K. Beale | Composition of pyruvate and protein and method for increasing protein concentration in a mammal |
| ITTO20020672A1 (it) * | 2002-07-26 | 2004-01-26 | Medestea Res And Production S | Composizioni farmaceutiche contenenti cheto-acidi per somministrazione endoperitoneale |
| US11484579B2 (en) | 2017-11-29 | 2022-11-01 | Edgar L Hull | Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients |
| WO2019108809A2 (en) * | 2017-11-29 | 2019-06-06 | Hull Edgar L Jr | Alpha keto acid compositions for treating hypo-albuminemia |
| US12109254B2 (en) | 2017-11-29 | 2024-10-08 | Edgar Hull | Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2335215B2 (de) * | 1972-07-13 | 1979-04-05 | The Johns Hopkins University, Baltimore, Md. (V.St.A.) | Verwendung einer Mischung bei der Bekämpfung von zur Urämie führenden Nierenerkrankungen |
| DE2531299A1 (de) * | 1975-07-12 | 1977-01-13 | Fresenius Chem Pharm Ind | L-amino- und hydroxy- und/oder ketosaeuren enthaltende gemische fuer parenterale oder orale anwendung |
| US4296127A (en) * | 1979-04-18 | 1981-10-20 | The Johns Hopkins University | Mixed salts of essential or semi-essential amino acids and nitrogen-free analogs thereof |
| ATE11736T1 (de) * | 1980-12-23 | 1985-02-15 | Dr. Franz Koehler Chemie Gmbh | Protektive loesung fuer herz und niere und verfahren zu deren herstellung. |
| JPS58500563A (ja) * | 1981-04-27 | 1983-04-14 | バクスタ−、トラベノ−ル、ラボラトリ−ズ、インコ−ポレイテツド | グルコ−ス、アミノ酸およびインシユリンを含む透析液 |
| WO1983000087A1 (en) * | 1981-07-10 | 1983-01-20 | Baxter Travenol Lab | Peritoneal dialysis solution containing carbohydrate polymers |
| US4491589A (en) * | 1982-05-17 | 1985-01-01 | The Trustees Of Columbia University In The City Of New York | Amino acid solutions for parenteral nutrition and methods of formulation and use |
| EP0250559A1 (en) * | 1985-12-18 | 1988-01-07 | VEECH, Richard L. | Parenteral nutrition therapy with amino acids |
| DE3821043A1 (de) * | 1988-06-22 | 1989-12-28 | Fresenius Ag | Dialysier- und spuel-loesung zur intraperitonealen verabreichung |
-
1989
- 1989-12-04 DE DE3940052A patent/DE3940052A1/de active Granted
-
1990
- 1990-11-29 AT AT90122823T patent/ATE104149T1/de not_active IP Right Cessation
- 1990-11-29 ES ES90122823T patent/ES2054200T3/es not_active Expired - Lifetime
- 1990-11-29 DE DE59005355T patent/DE59005355D1/de not_active Expired - Fee Related
- 1990-11-29 EP EP90122823A patent/EP0431465B1/de not_active Expired - Lifetime
- 1990-11-29 DK DK90122823.9T patent/DK0431465T3/da active
- 1990-12-03 WO PCT/EP1990/002078 patent/WO1991008009A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE59005355D1 (de) | 1994-05-19 |
| WO1991008009A1 (de) | 1991-06-13 |
| EP0431465A1 (de) | 1991-06-12 |
| ATE104149T1 (de) | 1994-04-15 |
| DE3940052A1 (de) | 1991-06-06 |
| ES2054200T3 (es) | 1994-08-01 |
| DK0431465T3 (da) | 1994-08-08 |
| EP0431465B1 (de) | 1994-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| 8122 | Nonbinding interest in granting licences declared | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BARTZ, VOLKER, 35625 HUETTENBERG, DE |
|
| 8339 | Ceased/non-payment of the annual fee |