DE3866860D1 - Thyrotropin abgebende hormonanaloge fuer verletzungen am zentralnervensystem. - Google Patents
Thyrotropin abgebende hormonanaloge fuer verletzungen am zentralnervensystem.Info
- Publication number
- DE3866860D1 DE3866860D1 DE8888906641T DE3866860T DE3866860D1 DE 3866860 D1 DE3866860 D1 DE 3866860D1 DE 8888906641 T DE8888906641 T DE 8888906641T DE 3866860 T DE3866860 T DE 3866860T DE 3866860 D1 DE3866860 D1 DE 3866860D1
- Authority
- DE
- Germany
- Prior art keywords
- prolineamide
- histidyl
- analog
- oxo
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000006378 damage Effects 0.000 title 1
- 239000003668 hormone analog Substances 0.000 title 1
- 208000001738 Nervous System Trauma Diseases 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 230000000302 ischemic effect Effects 0.000 abstract 2
- 208000028412 nervous system injury Diseases 0.000 abstract 2
- XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical class NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 abstract 2
- 239000003045 protirelin derivative Substances 0.000 abstract 2
- 230000000472 traumatic effect Effects 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- VLJNHYLEOZPXFW-BYPYZUCNSA-N L-prolinamide Chemical group NC(=O)[C@@H]1CCCN1 VLJNHYLEOZPXFW-BYPYZUCNSA-N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 abstract 1
- 229910052740 iodine Chemical group 0.000 abstract 1
- 239000011630 iodine Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5833987A | 1987-06-05 | 1987-06-05 | |
| PCT/US1988/001837 WO1988009604A2 (en) | 1987-06-05 | 1988-06-06 | Thyrotropin-releasing hormone analogs in cns injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3866860D1 true DE3866860D1 (de) | 1992-01-23 |
Family
ID=22016211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8888906641T Expired - Lifetime DE3866860D1 (de) | 1987-06-05 | 1988-06-06 | Thyrotropin abgebende hormonanaloge fuer verletzungen am zentralnervensystem. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0317624B1 (de) |
| JP (1) | JPH01503542A (de) |
| AT (1) | ATE70186T1 (de) |
| CA (1) | CA1323301C (de) |
| DE (1) | DE3866860D1 (de) |
| WO (1) | WO1988009604A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE20000240A1 (en) | 2000-02-17 | 2003-03-05 | Trinity College Dublin | TRH-like peptide derivatives |
| DE10105041A1 (de) | 2001-02-05 | 2002-08-14 | Tell Pharm Ag Hergiswil | Tripeptide und Tripeptid-Derivate für die Behandlung neurodegenerativer Krankheiten |
| DE10105040A1 (de) | 2001-02-05 | 2002-08-14 | Tell Pharm Ag Hergiswil | Tripeptid-Derivate für die Behandlung von postläsionalen Krankheiten des Nervensystems |
| DE10105038B4 (de) | 2001-02-05 | 2005-07-07 | Neurotell Ag | Tripeptid-Derivate für die Behandlung von postläsionalen Krankheiten des Nervensystems |
| GB0128405D0 (en) | 2001-11-27 | 2002-01-16 | Btg Int Ltd | Process for fabricating polyolefin sheet |
-
1988
- 1988-06-03 CA CA000568686A patent/CA1323301C/en not_active Expired - Fee Related
- 1988-06-06 WO PCT/US1988/001837 patent/WO1988009604A2/en active IP Right Grant
- 1988-06-06 EP EP88906641A patent/EP0317624B1/de not_active Expired - Lifetime
- 1988-06-06 AT AT88906641T patent/ATE70186T1/de active
- 1988-06-06 DE DE8888906641T patent/DE3866860D1/de not_active Expired - Lifetime
- 1988-06-06 JP JP63506706A patent/JPH01503542A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATE70186T1 (de) | 1991-12-15 |
| CA1323301C (en) | 1993-10-19 |
| EP0317624A1 (de) | 1989-05-31 |
| JPH01503542A (ja) | 1989-11-30 |
| WO1988009604A2 (en) | 1988-12-15 |
| EP0317624B1 (de) | 1991-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: MEDICIS PHARMACEUTICAL CORP. (N.D.GES.D.STAATES DE |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: GEORGETOWN UNIVERSITY, WASHINGTON, D.C., US |
|
| 8339 | Ceased/non-payment of the annual fee |