DE3865384D1 - Verfahren zur herstellung von zwischenprodukten fuer die synthese des fosfomycins. - Google Patents

Verfahren zur herstellung von zwischenprodukten fuer die synthese des fosfomycins.

Info

Publication number
DE3865384D1
DE3865384D1 DE8888111335T DE3865384T DE3865384D1 DE 3865384 D1 DE3865384 D1 DE 3865384D1 DE 8888111335 T DE8888111335 T DE 8888111335T DE 3865384 T DE3865384 T DE 3865384T DE 3865384 D1 DE3865384 D1 DE 3865384D1
Authority
DE
Germany
Prior art keywords
fosfomycin
synthesis
intermediate products
producing intermediate
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888111335T
Other languages
English (en)
Inventor
Graziano Castaldi
Claudio Giordano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon SpA
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT21303/87A external-priority patent/IT1222041B/it
Priority claimed from IT23125/87A external-priority patent/IT1223564B/it
Application filed by Zambon SpA filed Critical Zambon SpA
Application granted granted Critical
Publication of DE3865384D1 publication Critical patent/DE3865384D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
DE8888111335T 1987-07-15 1988-07-14 Verfahren zur herstellung von zwischenprodukten fuer die synthese des fosfomycins. Expired - Fee Related DE3865384D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT21303/87A IT1222041B (it) 1987-07-15 1987-07-15 Processo per la preparazione di intermedi per la sintesi della fosfomicina
IT23125/87A IT1223564B (it) 1987-12-21 1987-12-21 Processo per la preparazione di intermedi per la sintesi della fosfomicina

Publications (1)

Publication Number Publication Date
DE3865384D1 true DE3865384D1 (de) 1991-11-14

Family

ID=26327859

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888111335T Expired - Fee Related DE3865384D1 (de) 1987-07-15 1988-07-14 Verfahren zur herstellung von zwischenprodukten fuer die synthese des fosfomycins.

Country Status (6)

Country Link
US (1) US4937367A (de)
EP (1) EP0299484B1 (de)
JP (1) JPH01104085A (de)
DE (1) DE3865384D1 (de)
ES (1) ES2037770T3 (de)
GR (1) GR3003256T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5731299A (en) * 1992-05-29 1998-03-24 The Procter & Gamble Company Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5470845A (en) * 1992-10-28 1995-11-28 Bristol-Myers Squibb Company Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia
DE10034412A1 (de) * 2000-07-14 2002-01-24 Leo Elektronenmikroskopie Gmbh Verfahren zur Elektronenstrahl-Lithographie und elektronen-optisches Lithographiesystem
CN1854146B (zh) * 2005-04-25 2011-06-01 北京科莱博医药开发有限责任公司 由右旋磷霉素制备左旋磷霉素的合成方法
WO2007101415A2 (de) * 2006-02-03 2007-09-13 Universität Stuttgart - Institut für Chemische Verfahrenstechnik Phosphonsäure-haltige blends und phosphonsäure-haltige polymere
CN100475773C (zh) * 2006-11-24 2009-04-08 李晓祥 萘二磺酸乙乳胆铵及其类似化合物的合成方法
WO2010035664A1 (ja) * 2008-09-24 2010-04-01 田辺三菱製薬株式会社 ビスホスホン酸誘導体の製法
JP6694713B2 (ja) * 2012-12-11 2020-05-20 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． （ｓ）−２−アセチルオキシプロピオン酸クロリドの連続製造方法
CN117964661B (zh) * 2024-04-01 2024-06-07 深圳创元生物医药科技有限公司 一种磷霉素基因毒杂质c的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE32804B1 (en) * 1968-05-15 1973-12-12 Merck & Co Inc Preparation of (cis-1,2-epoxypropyl)phosphonic acid and derivatives thereof
US3657282A (en) * 1969-01-23 1972-04-18 Merck & Co Inc Carboxyepoxyethyl-1-phosphonic acid and derivatives
US3819676A (en) * 1969-04-25 1974-06-25 Merck & Co Inc Alkyl-or arylsulfonyloxy,alkanoyloxy substituted propylphosphoric acid lower alkyl esters

Also Published As

Publication number Publication date
EP0299484B1 (de) 1991-10-09
GR3003256T3 (en) 1993-02-17
JPH01104085A (ja) 1989-04-21
ES2037770T3 (es) 1993-07-01
US4937367A (en) 1990-06-26
EP0299484A1 (de) 1989-01-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee