DE3861059D1 - Antihypercholesterin-beta-lactone. - Google Patents

Antihypercholesterin-beta-lactone.

Info

Publication number
DE3861059D1
DE3861059D1 DE8888304491T DE3861059T DE3861059D1 DE 3861059 D1 DE3861059 D1 DE 3861059D1 DE 8888304491 T DE8888304491 T DE 8888304491T DE 3861059 T DE3861059 T DE 3861059T DE 3861059 D1 DE3861059 D1 DE 3861059D1
Authority
DE
Germany
Prior art keywords
antihypercholesterin
lactone
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888304491T
Other languages
English (en)
Inventor
Des Erfinders Beantragt Teilnichtnennung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3861059D1 publication Critical patent/DE3861059D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
DE8888304491T 1987-05-26 1988-05-18 Antihypercholesterin-beta-lactone. Expired - Fee Related DE3861059D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/053,774 US4806564A (en) 1987-05-26 1987-05-26 Antihypercholesterolemic beta-lactones

Publications (1)

Publication Number Publication Date
DE3861059D1 true DE3861059D1 (en) 1990-12-20

Family

ID=21986440

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888304491T Expired - Fee Related DE3861059D1 (en) 1987-05-26 1988-05-18 Antihypercholesterin-beta-lactone.

Country Status (5)

Country Link
US (1) US4806564A (de)
EP (1) EP0293132B1 (de)
JP (1) JPS63307868A (de)
CA (1) CA1284333C (de)
DE (1) DE3861059D1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8623771D0 (en) * 1986-10-03 1986-11-05 Ici Plc Chemical compounds
US4873260A (en) * 1988-06-27 1989-10-10 Merck & Co., Inc. Treatment of diabetic ketoacidosis
US5064856A (en) * 1989-07-31 1991-11-12 Merck & Co., Inc. Novel hmg-coa synthase inhibitors
US4983597A (en) * 1989-08-31 1991-01-08 Merck & Co., Inc. Beta-lactams as anticholesterolemic agents
US5120729A (en) * 1990-06-20 1992-06-09 Merck & Co., Inc. Beta-lactams as antihypercholesterolemics
US5135935A (en) * 1991-05-17 1992-08-04 Merck & Co., Inc. Squalene synthetase inhibitors
EP0526936A3 (en) 1991-08-02 1993-05-05 Merck & Co. Inc. Cholesterol-lowering agents
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
WO1998001100A2 (en) * 1996-07-09 1998-01-15 Merck & Co., Inc. Method for treating homozygous familial hypercholesterolemia
AU2003226370A1 (en) * 2002-04-17 2003-11-03 The Burnham Institute Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
US7728153B2 (en) 2002-04-17 2010-06-01 The Burnham Institute For Medical Research Method for the asymmetric synthesis of beta-lactone compounds
DE102004009076A1 (de) * 2004-02-23 2005-10-27 Solvay Pharmaceuticals Gmbh Alkylcarbamat-substituierte β-Lactone, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US7074822B2 (en) 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
ES2901114T3 (es) 2014-08-29 2022-03-21 Tes Pharma S R L Inhibidores de ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa
KR20190065312A (ko) 2016-10-14 2019-06-11 테스 파마 에스.알.엘. 알파-아미노-베타-카복시뮤콘산 세미알데하이드 데카복실라제의 저해제
WO2020104456A1 (en) 2018-11-20 2020-05-28 Tes Pharma S.R.L INHIBITORS OF α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56128774A (en) * 1980-03-14 1981-10-08 Microbial Chem Res Found New physiologically active substance ebelactone and its preparation
CA1247547A (en) * 1983-06-22 1988-12-28 Paul Hadvary Leucine derivatives
DE3434212A1 (de) * 1984-09-18 1986-03-20 Schill & Seilacher GmbH & Co, 7030 Böblingen Verfahren zur herstellung von ketendimeren und deren verwendung
CA1270837A (en) * 1984-12-21 1990-06-26 Hoffmann-La Roche Limited Oxetanones
US4751237A (en) * 1986-01-27 1988-06-14 Merck & Co., Inc. Antihypercholesterolemic beta-lactones

Also Published As

Publication number Publication date
EP0293132B1 (de) 1990-11-14
JPS63307868A (ja) 1988-12-15
EP0293132A1 (de) 1988-11-30
CA1284333C (en) 1991-05-21
US4806564A (en) 1989-02-21

Similar Documents

Publication Publication Date Title
DE3878589D1 (en) Buerstendichtungen.
DE3863660D1 (en) Aminomethylheterocyclen.
DE3864664D1 (en) Koerperstativ.
DE3854331D1 (en) Eisnachweisschaltung.
DE3866200D1 (en) Oelablassventil.
DE3866723D1 (en) Thermoplastische polyamidformmassen.
DE3877968D1 (en) Hochamorphes olefinterpolymer.
DE3765420D1 (en) Huelsengummifeder.
DE3852484D1 (en) Ionomerzubereitung.
DE3862796D1 (en) Emp - generator.
DE3877909D1 (en) Rotorauswuchtung.
DE3875006D1 (en) Waermepumpensystem.
DE3876364D1 (en) Muenzbehandlungsvorrichtung.
DE3874785D1 (en) Duennfilmkondensator.
DE3868170D1 (en) Polyurethanklebstoff.
DE3867135D1 (en) Thermo-transferdrucker.
DE3878640D1 (en) Pedalplatte.
DE3860893D1 (en) Waescheweichmacherzusammensetzung.
DE3868953D1 (en) Heckbruecke.
DE3877459D1 (en) Pyrimidinderivate.
DE3861059D1 (en) Antihypercholesterin-beta-lactone.
DE3866184D1 (en) Buten-1-copolymer.
DE3769639D1 (en) Tuerschliesser.
DE3852648D1 (en) Hypersystolischer reed-solomon-encoder.
DE3873965D1 (en) Rotations-hydraulikmaschine.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee