DE3855121D1 - Anxiolytisch wirksame Piperazinderivate - Google Patents

Anxiolytisch wirksame Piperazinderivate

Info

Publication number
DE3855121D1
DE3855121D1 DE3855121T DE3855121T DE3855121D1 DE 3855121 D1 DE3855121 D1 DE 3855121D1 DE 3855121 T DE3855121 T DE 3855121T DE 3855121 T DE3855121 T DE 3855121T DE 3855121 D1 DE3855121 D1 DE 3855121D1
Authority
DE
Germany
Prior art keywords
piperazine derivatives
anxiolytic
properties
dosages
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3855121T
Other languages
English (en)
Other versions
DE3855121T2 (de
Inventor
Jan Hartog
Johannes Mos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Application granted granted Critical
Publication of DE3855121D1 publication Critical patent/DE3855121D1/de
Publication of DE3855121T2 publication Critical patent/DE3855121T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
DE3855121T 1987-09-11 1988-09-09 Anxiolytisch wirksame Piperazinderivate Expired - Fee Related DE3855121T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8702167 1987-09-11

Publications (2)

Publication Number Publication Date
DE3855121D1 true DE3855121D1 (de) 1996-04-25
DE3855121T2 DE3855121T2 (de) 1996-08-22

Family

ID=19850597

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3855121T Expired - Fee Related DE3855121T2 (de) 1987-09-11 1988-09-09 Anxiolytisch wirksame Piperazinderivate

Country Status (13)

Country Link
US (1) US4889852A (de)
EP (1) EP0307061B1 (de)
JP (1) JP2749593B2 (de)
AT (1) ATE135576T1 (de)
AU (1) AU618279B2 (de)
CA (1) CA1327163C (de)
DE (1) DE3855121T2 (de)
DK (1) DK172628B1 (de)
ES (1) ES2085852T3 (de)
GR (1) GR3019544T3 (de)
IE (1) IE74200B1 (de)
IL (1) IL87712A (de)
ZA (1) ZA886694B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK172628B1 (da) * 1987-09-11 1999-08-02 Duphar Int Res Anvendelse af piperazinderivater til fremstilling af lægemidler til behandling af syndromer, der involverer frygt eller fry
US5219855A (en) * 1988-01-29 1993-06-15 Mitsubishi Kasei Corporation Anxiolytic drug
US4983612A (en) * 1989-10-05 1991-01-08 American Home Products Corporation Antihypertensive benzopyran derivatives
US5162324A (en) * 1989-12-20 1992-11-10 Adir Et Compagnie Naphyl piperazines useful as 5-HT1A receptor ligands
FR2655988B1 (fr) * 1989-12-20 1994-05-20 Adir Cie Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ATE182367T1 (de) * 1992-12-21 1999-08-15 Duphar Int Res Enzymatisches verfahren zur stereoselektiven herstellung einem enantiomer aus einem hetero bicyclischen alkohols
EP1408976B3 (de) 2001-07-20 2010-08-25 Psychogenics Inc. Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
US9066903B2 (en) 2006-02-28 2015-06-30 The United States Of America As Represented By The Department Of Veterans Affairs Pharmacological treatment of Parkinson's disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK169601B1 (da) * 1983-10-17 1994-12-19 Duphar Int Res Piperazinderivater og farmaceutisk præparat indeholdende et sådant derivat, samt piperazinderivater med mellemproduktanvendelse
ATE81975T1 (de) * 1984-12-21 1992-11-15 Duphar Int Res Arzneimittel mit psychotroper wirkung.
DE3571436D1 (en) * 1984-12-21 1989-08-17 Duphar Int Res New pharmaceutical compositions having anti-psychotic properties
DK172628B1 (da) * 1987-09-11 1999-08-02 Duphar Int Res Anvendelse af piperazinderivater til fremstilling af lægemidler til behandling af syndromer, der involverer frygt eller fry

Also Published As

Publication number Publication date
EP0307061A2 (de) 1989-03-15
JP2749593B2 (ja) 1998-05-13
AU2207688A (en) 1989-05-11
DK497288D0 (da) 1988-09-07
DE3855121T2 (de) 1996-08-22
EP0307061A3 (de) 1991-07-17
IE74200B1 (en) 1997-07-16
IL87712A (en) 1992-12-01
US4889852A (en) 1989-12-26
GR3019544T3 (en) 1996-07-31
ES2085852T3 (es) 1996-06-16
EP0307061B1 (de) 1996-03-20
AU618279B2 (en) 1991-12-19
DK497288A (da) 1989-03-12
ATE135576T1 (de) 1996-04-15
JPH01100169A (ja) 1989-04-18
DK172628B1 (da) 1999-08-02
IE882697L (en) 1989-03-11
IL87712A0 (en) 1989-02-28
ZA886694B (en) 1989-06-28
CA1327163C (en) 1994-02-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee