DE3809815C2 - - Google Patents

Info

Publication number
DE3809815C2
DE3809815C2 DE19883809815 DE3809815A DE3809815C2 DE 3809815 C2 DE3809815 C2 DE 3809815C2 DE 19883809815 DE19883809815 DE 19883809815 DE 3809815 A DE3809815 A DE 3809815A DE 3809815 C2 DE3809815 C2 DE 3809815C2
Authority
DE
Germany
Prior art keywords
electrode
electrode tube
tube
connector
receptacle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19883809815
Other languages
German (de)
Other versions
DE3809815A1 (en
Inventor
Peter 7910 Neu-Ulm De Zimmer
Karl Heinz Dr.Med. 7100 Heilbronn De Thiel
Original Assignee
Peter 7910 Neu-Ulm De Zimmer
Karl Heinz Dr.Med. 7100 Heilbronn De Thiel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peter 7910 Neu-Ulm De Zimmer, Karl Heinz Dr.Med. 7100 Heilbronn De Thiel filed Critical Peter 7910 Neu-Ulm De Zimmer
Priority to DE19883809815 priority Critical patent/DE3809815C2/de
Publication of DE3809815A1 publication Critical patent/DE3809815A1/en
Application granted granted Critical
Publication of DE3809815C2 publication Critical patent/DE3809815C2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303Constructional details
    • A61N1/306Arrangements where at least part of the apparatus is introduced into the body

Description

The invention relates to a body cavity insertable inner electrode for iontophoretic transport of active substances (drugs) in the wall of the Body cavity for regional drug treatment of the wall tissue, especially for intravesical antineoplastic iontophoresis for the therapy of Bladder cancer, with an electrode tube attached to his completed at the distal end and in its wall with a Row of through openings is provided, and that on proximal tube end has two connections, namely one electrical connection for electrical connection of the Electrode tube with one pole of an electrical Current-voltage generator and a line connection for Connection of the liquid instillate to and laxative pipe with the interior of the Electrode tube.

With an inner electrode known from AT-PS 1 08 754 In this way, the electrode tube does not consist of electricity conductive material. There is a inside the pipe Metallic partition providing power supply. At others, from FR-PS 8 55 841 or GB-PS 3 34 672 known generic internal electrodes takes place Power supply through one inside the also electrically non-conductive electrode tube metallic wire.  

In CH-PS 29 107 is an electric mouth bath with an electrode described as a drinking vessel in Shape of a bottle with a mouthpiece perforated electrode tube is made of metal, from the outside when using the drinking vessel Electricity flows directly into the inside of the mouth.

DE 33 37 470 A1 describes an implantable Glassy carbon electrode placed in an outer Shape from an electrode shaft and one Electrode head in massive form after an elaborate Process by pyrolytic transfer of a synthetic resin must be made in glassy carbon.

Internal electrodes of the generic type serve a the instillate containing the medicinal active ingredient in the Body cavity and by iontophoresis Active ingredient also highly concentrated in the deeper layers of the Introduce wall tissue of the body cavity. Here can become so therapeutically effective Pharmacon tissue concentrations result as with other applications cannot be reached.

In such healing methods, the invention is in Connection with the use of a special active pharmaceutical ingredient according to patent 38 09 814. Die inner electrode according to the invention is the requirements specially adapted to this medication use. she wears the fact that the nature of the Drug the electrical circuit of the inner electrode  required as an anode. However, it must be avoided that ions are split off from the electrode material, which as foreign ions form the therapeutic instillate in the Could contaminate the senses that the foreign ions with the competing iontophoretically transported drugs, what a reduction in methodological efficiency to Would mean ineffectiveness.

The invention is therefore based on the object To design the inner electrode of the type mentioned in the introduction avoiding electrolytic corrosion of the electrode and direct electrical contact between electrical conductive electrode parts and the inner wall of the Body cavity can not occur.

This object is achieved according to the invention in that the electrode tube is electrically conductive and made carbon fiber reinforced plastic KFK and at least on its application in the Body cavity inserted an electrical length insulating, penetrated only by the through openings has outer casing.

The material of the electrode tube carbon fiber reinforced plastic provides the necessary electrical conductivity of the inner electrode and avoids reliably the risk of electrolytic corrosion the electrode and thus the elimination of foreign ions from the electrode material. The electrode tube is through the casing is electrically insulated from the outside, the active one The electrode surface is only inside the Electrode tube, so that even in places  Place the electrode tube against the wall of the body cavity but no direct current flow between the Form the electrode tube and the wall of the body cavity can, that is, impermissibly high current densities that would otherwise occur in in such a case could be avoided. Through the combination of the carbon fiber plastic tube and the Sheathing will not only be for those Internal electrode required electrical properties realized but also very advantageous mechanical Preserve properties of the inner electrode. So it can Electrode tube with both a smaller outer diameter as well as small wall thickness, i.e. in relation to its Outside dimensions are formed with a large lumen, which in With regard to cleaning and sterilizing the electrode of is of great importance. In addition, the material the jacket is chosen independently of that of the pipe be so that the sheathing material with respect to its Surface properties can be optimally selected, which with regard to, for example, the slidability when Inserting the inner electrode into the body cavity is important is.

The material of the electrode tube preferably has Epoxy or polyester resin as a plastic matrix and the sheathing consists of polyamide, polyester, epoxy or plexiglass.

It is also recommended that to form the two Connections at the proximal end are not there jacketed electrode tube axially two in a row Fitting fittings that place the electrode tube in axial record aligned holes, the one Connector one collar with external thread and the other  Connector with a female thread for the Has collar and with each other between the end face the collar and the bottom of the receptacle one that Form the annular groove surrounding the electrode tube, in which a Sealing ring is arranged, when the thread is tightened between the fittings and the electrode tube is pressed, whereby the connectors on the Electrode tube held and with their holes against the electrode tube is sealed. Preferably in the bore of the rear connector sealed one  sleeve electrically insulated from the electrode tube with a Quick-release fastener for those who feed or discharge the instillate Line used. The front connector points expediently a receptacle for a connecting member electrical line, taking as one radial bore can be formed up to Electrode tube is sufficient and a thread to screw in the Has connecting member. The one screwed into the holder Connector presses against the electrode tube and thus gives the desired electrical contact with the electrode tube and an additional mechanical Hold the connectors on the electrode tube.

In further training, it is recommended that the two Connectors on the mutually facing edges are bevelled and with these bevels between form a grip groove that is simple and sensitive handling of the electrode tube results. It is useful to bevel the front Connection piece steeper than the bevel of the rear Connector against the axis of the electrode tube inclined what the fingers of the electrode tube holding and leading hand a particularly good grip adjustment gives.

Another suggestion is in the surface of the Electrode tube a variety of small and flat Wells provided that are bowl-like, in particular can be designed as a ball valve. For insertion the lubricant used in the electrode tube experiences in the Deepens a storage and is still effective when the electrode tube is removed after the treatment becomes.

The following is an embodiment of the invention with reference to the drawing explained in more detail; it demonstrate:

Fig. 1 is an axial section through an internal electrode according to one embodiment of the invention,

Fig. 2 shows a cross section in the direction II-II through the electrode according to FIG. 1 in an enlarged scale;

Fig. 3 is a schematic drawing for explaining the application of the inner electrode of FIG. 1.

The inner electrode shown in the drawing consists of an electrically conductive electrode tube 1 , which is closed at its distal end 1 ' by a cap and is provided in its wall with a number of through openings 3 . At least over its length introduced into the body cavity during application, the electrode tube 1 is provided with an outer sheath 4 which is electrically insulating to the outside and only penetrated by the through openings 3 . At the proximal end of the electrode tube 1 there are two connections 5 , 6 , namely an electrical connection 5 for the electrical connection of the electrode tube 1 to the positive pole in the exemplary embodiment of an electrical current-voltage generator 7 shown only schematically in FIG. 3, and a line connection 6 for connection a line supplying the liquid instillate to the interior of the electrode tube 1 . The cap 2 , which closes the electrode tube 1 , is also electrically insulating and tightly connected to the casing 4 . The cap 2 is inserted with a pin 2 ' in the electrode tube 1 and consists of glass fiber reinforced plastic GRP. The sheathing 4 consists of a polyamide coating on the electrode tube 1 , which then connects particularly easily to the material of the cap 2 if this material has polyamide as a plastic matrix. The cap can then be glued or welded to the electrode tube and the casing.

The through openings 3 are diametrically opposed in pairs. In the direction of the axis of the electrode tube 1 successive through openings 3 are each offset by 90 ° to each other. In a practical exemplary embodiment, 42 such through openings 3 with a diameter of 1.8 mm each can be provided, which together form a total opening cross section of approximately 107 mm 2 . The electrode tube 1 consists of carbon fiber-reinforced plastic KFK, for example 40% carbon fiber and 60% glass fiber, epoxy resin, optionally also polyester resin, being used as the plastic matrix. The electrode tube 1 has an outer diameter of 5.6 mm with a wall thickness of 1 mm, so that the inside diameter is 3.6 mm. The casing 4 is 0.1 mm thick, so that the electrode tube 1 including the casing 4 has an outer diameter of 5.8 mm. The sheath 4 extends over the entire tube length of about 270 mm with the exception of the proximal end part 1 '' of about 35 mm in length, which is not electrically insulated and carries the connections 5 , 6 . The through openings 3 extend over a length of the electrode tube 1 of approximately 47 to 50 mm. The overall clear cross section of all through openings 3 together is considerably larger than the clear cross section of the electrode tube 1 .

To form the two connections 5 , 6 at the proximal end 1 '' on the electrode tube 1 not covered there sit axially one behind the other two made of electrically insulating material, esp. Polyamide, existing connectors 5 ' , 6' . You take the electrode tube 1 in axially aligned bores 8 , the one connector 5 'has a collar 9 with an external thread and the other connector 6' has a receptacle 10 with an internal thread for the collar 9 . The two connecting pieces 5 ' , 6' form with one another between the end face of the collar 9 and the bottom of the receptacle 10 an annular groove surrounding the electrode tube 1 . In this annular groove 11 there is a sealing ring 11 ', which in the tightened threaded between the connecting pieces 5', 6 'and the electrode tube 1 in the annular groove 11 is pressed. Characterized the connectors 5 ' , 6' on the electrode tube 1 in the friction seat and at the same time sealed with their holes 8 against the electrode tube 1 . In the bore 8 of the rear connector 6 ' is electrically insulated and sealed against the electrode tube 1, a sleeve 12 with a quick-release fastener 13 , for example a bayonet lock, for which the instillate supply or discharge, only indicated in Fig. 3 line 14 is used. The front connector 5 ' has a receptacle 15 for a connector 16 of an electrical line 17th This receptacle 15 is designed as a radial bore which extends to the electrode tube 1 and has an internal thread 18 for screwing in the connecting member 16 . Via the internal thread 18 , the connecting member 16 is pressed against the electrode tube 1 and thereby electrically contacted with the electrode tube and also mechanically connected again in the friction fit.

The two connecting pieces 5 ' , 6' are chamfered at the mutually facing edges at 19, 20 and form a grip groove with these chamfers between them. The bevel 19 of the front connector 5 ' is inclined more steeply against the axis of the electrode tube 1 than the bevel 20 of the rear connector 6' , so that the fingers and the thumb of the hand brought from the back put well into the grip groove.

For the treatment of, for example, bladder carcinoma, the inner electrode according to FIG. 3 with the distal end 1 ' is inserted through the urethra 25 into the bladder 26 , the electrode tube 1 wherever it can come into contact with the bladder or urethra through the jacket 4 is electrically insulated. The through openings 3 then lie within the bladder 26 , and the instillate is fed into the bladder through the electrode tube 1 and, at the same time, the electrical current causing the iontophoretic transport. B. forms the positive electrode of a pair of electrodes, the negative electrode 27 is applied in a belt shape on the outside of the body. The arrows in FIG. 3 mark the current direction or the active substance transport from the bladder lumen into the bladder wall and to the negative outer electrode. The bladder instillate introduced into the bladder 26 through the electrode tube 1 is a mixture of distilled water and a suitable dissociable pharmaceutical.

Claims (11)

1. An inner electrode that can be inserted into a body cavity for the iontophoretic transport of active substances (medicinal products) into the wall of the body cavity for regional medicinal treatment of the wall tissue, in particular for intravesical antineoplastic iontophoresis for the therapy of bladder cancer, with an electrode tube ( 1 ), which at its distal end ( 1 ′ ) is closed and provided in its wall with a series of through openings ( 3 ), and which has two connections ( 5, 6 ) at the proximal tube end ( 1 ″ ), namely an electrical connection ( 5 ) for the electrical connection of the electrode tube ( 1 ) with the one pole of an electric current-voltage generator ( 7 ) and a line connection ( 6 ) for connecting a line ( 14 ) supplying and discharging the liquid instillate to the interior of the electrode tube ( 1 ), characterized in that the electrode tube ( 1 ) is electrically conductive and made of carbon fiber reinforced plastic KFK and at least along its length introduced into the body cavity during application has an electrically insulating outer sheath ( 4 ) only penetrated by the through openings ( 3 ).
2. Inner electrode according to claim 1, characterized in that the material of the electrode tube ( 1 ) has epoxy or polyester resin as a plastic matrix.
3. Inner electrode according to claim 1 or 2, characterized in that the casing ( 4 ) consists of polyamide, polyester, epoxy or plexiglass.
4. Inner electrode according to one of claims 1 to 3, characterized in that to form the two connections ( 5, 6 ) at the proximal end ( 1 ″ ) on the electrode tube ( 1 ) not covered there axially one after the other two connecting pieces ( 5 ', 6 ' ) Sit, which receive the electrode tube ( 1 ) in axially aligned bores ( 8 ), the one connector ( 5' ) a collar ( 9 ) with an external thread and the other connector ( 6 ' ) a receptacle ( 10 ) with an internal thread for have the collar ( 9 ) and together between the end face of the collar ( 9 ) and the bottom of the receptacle ( 10 ) form an annular groove ( 11 ) surrounding the electrode tube ( 1 ) in which a sealing ring ( 11 ' ) is arranged, which when tightened Thread fit between the connecting pieces ( 5 ', 6' ) and the electrode tube ( 1 ) is pressed, whereby the connecting pieces ( 5 ', 6' ) are held on the electrode tube ( 1 ) and with their bores ( 8 ) against the electrode tube r ( 1 ) are sealed.
5. Inner electrode according to claim 4, characterized in that in the bore ( 8 ) of the rear connection piece ( 6 ' ) sealed a from the electrode tube ( 1 ) electrically insulated sleeve ( 12 ) with a quick release ( 13 ) for the instillate or Laxative line ( 14 ) is used.
6. Inner electrode according to claim 4 or 5, characterized in that the front connector ( 5 ' ) has a receptacle ( 15 ) for a connecting member ( 16 ) of an electrical line ( 17 ).
7. Internal electrode according to claim 6, characterized in that the receptacle ( 15 ) is designed as a radial bore which extends to the electrode tube ( 1 ) and has an internal thread ( 18 ) for screwing in the connecting member ( 16 ).
8. Inner electrode according to one of claims 5 to 7, characterized in that the two connecting pieces ( 5 ', 6' ) are chamfered on the mutually facing edges and with these chamfers ( 19, 20 ) form a grip groove between them.
9. Inner electrode according to claim 8, characterized in that the chamfer ( 19 ) of the front connector ( 5 ' ) is steeper than the chamfer ( 20 ) of the rear connector ( 6' ) against the axis of the electrode tube ( 1 ) is inclined.
10. Inner electrode according to one of claims 1 to 9, characterized characterized in that in the surface of the Electrode tube a variety of small and flat Recesses is provided.
11. Inner electrode according to claim 10, characterized characterized in that the depressions are bowl-like, are designed in particular in the form of a ball valve.
DE19883809815 1988-03-23 1988-03-23 Expired - Fee Related DE3809815C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19883809815 DE3809815C2 (en) 1988-03-23 1988-03-23

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19883809815 DE3809815C2 (en) 1988-03-23 1988-03-23

Publications (2)

Publication Number Publication Date
DE3809815A1 DE3809815A1 (en) 1989-10-12
DE3809815C2 true DE3809815C2 (en) 1990-06-28

Family

ID=6350499

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19883809815 Expired - Fee Related DE3809815C2 (en) 1988-03-23 1988-03-23

Country Status (1)

Country Link
DE (1) DE3809815C2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5988169A (en) * 1996-03-29 1999-11-23 Iotek, Inc. Vaginal insert and method for treating urogenital disorders
US6030375A (en) * 1996-03-29 2000-02-29 Iotek, Inc. Compressible vaginal insert and method for treating urogenital disorders

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3915636C1 (en) 1989-05-12 1990-04-26 Sass, Wolfgang, Dr.
EP0438078B1 (en) * 1990-01-15 1996-06-05 Cino Rossi Iontophoresis device
AT398274B (en) * 1990-03-22 1994-11-25 Buertlmair Hermann Electrode for electrical measuring devices and the like
US5236413B1 (en) * 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5421818A (en) * 1993-10-18 1995-06-06 Inner Ear Medical Delivery Systems, Inc. Multi-functional inner ear treatment and diagnostic system
AU8577098A (en) * 1997-07-22 1999-02-16 Emed Corporation Needle for iontophoretic delivery of agent
US6139538A (en) * 1997-10-06 2000-10-31 Iotek, Inc. Iontophoretic agent delivery to the female reproductive tract

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH29107A (en) * 1903-09-09 1904-07-15 Stanger J J Electric mouth bathing apparatus
AT108754B (en) * 1926-03-24 1928-02-10 Wilhelm Dr Richter Electrotherapeutic instrument for Gonorrhöebehandlung.
US1740240A (en) * 1928-06-11 1929-12-17 Charles F Honey Cataphoric electrode
BE361642A (en) * 1929-06-12
US2008754A (en) * 1934-02-20 1935-07-23 Myron J Drachman Electromedical instrument
BE436937A (en) * 1938-12-07
DE2124684A1 (en) * 1971-05-18 1972-11-30 Stadelmann W
DE3306037A1 (en) * 1983-02-22 1984-08-23 Steindorf Susanne Ruth Device for galvanic electrostimulation in urinary or rectal incontinence
DE3337470A1 (en) * 1983-10-14 1985-04-25 Siemens Ag Method for producing implantable electrodes from carbon fiber
DE3602219A1 (en) * 1986-01-25 1987-07-30 Vygon Erzeugnisse Neuroelectrode

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5988169A (en) * 1996-03-29 1999-11-23 Iotek, Inc. Vaginal insert and method for treating urogenital disorders
US6030375A (en) * 1996-03-29 2000-02-29 Iotek, Inc. Compressible vaginal insert and method for treating urogenital disorders

Also Published As

Publication number Publication date
DE3809815A1 (en) 1989-10-12

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee