DE3789436D1 - Heteroring-substituierte Diphosphonatverbindungen, Arzneimittel und Verfahren zur Behandlung von abnormalen Kalzium- und Phosphatmetabolismen. - Google Patents
Heteroring-substituierte Diphosphonatverbindungen, Arzneimittel und Verfahren zur Behandlung von abnormalen Kalzium- und Phosphatmetabolismen.Info
- Publication number
- DE3789436D1 DE3789436D1 DE87202530T DE3789436T DE3789436D1 DE 3789436 D1 DE3789436 D1 DE 3789436D1 DE 87202530 T DE87202530 T DE 87202530T DE 3789436 T DE3789436 T DE 3789436T DE 3789436 D1 DE3789436 D1 DE 3789436D1
- Authority
- DE
- Germany
- Prior art keywords
- heterocycle
- methods
- nitrogen
- phosphate
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title abstract 2
- 229910019142 PO4 Inorganic materials 0.000 title abstract 2
- 230000002159 abnormal effect Effects 0.000 title abstract 2
- 239000011575 calcium Substances 0.000 title abstract 2
- 229910052791 calcium Inorganic materials 0.000 title abstract 2
- 230000004060 metabolic process Effects 0.000 title abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title abstract 2
- 239000010452 phosphate Substances 0.000 title abstract 2
- XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical class [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 title 1
- 239000003814 drug Chemical class 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical class C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000005331 diazinyl group Chemical group N1=NC(=CC=C1)* 0.000 abstract 1
- XQRLCLUYWUNEEH-UHFFFAOYSA-N diphosphonic acid Chemical class OP(=O)OP(O)=O XQRLCLUYWUNEEH-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000004306 triazinyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6521—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94506886A | 1986-12-19 | 1986-12-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3789436D1 true DE3789436D1 (de) | 1994-04-28 |
| DE3789436T2 DE3789436T2 (de) | 1994-08-25 |
Family
ID=25482570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3789436T Expired - Fee Related DE3789436T2 (de) | 1986-12-19 | 1987-12-16 | Heteroring-substituierte Diphosphonatverbindungen, Arzneimittel und Verfahren zur Behandlung von abnormalen Kalzium- und Phosphatmetabolismen. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0274158B1 (de) |
| JP (1) | JPS63239291A (de) |
| KR (1) | KR960001845B1 (de) |
| AT (1) | ATE103286T1 (de) |
| AU (1) | AU616391B2 (de) |
| CA (1) | CA1321198C (de) |
| DE (1) | DE3789436T2 (de) |
| DK (1) | DK670487A (de) |
| IE (1) | IE61881B1 (de) |
| IL (1) | IL84731A0 (de) |
| NZ (1) | NZ222986A (de) |
| PH (1) | PH26154A (de) |
| ZA (1) | ZA879454B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3640938A1 (de) * | 1986-11-29 | 1988-06-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| GB8808138D0 (en) * | 1988-04-07 | 1988-05-11 | Leo Pharm Prod Ltd | Chemical compounds |
| DE3822650A1 (de) * | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| EP0521622B1 (de) * | 1991-07-03 | 1997-08-13 | PHARMACIA & UPJOHN COMPANY | Pyrazolopyrimiden- und Pyrimidinylbisphosphonsäureester als entzündungshemmende Mittel |
| US5283057A (en) * | 1992-04-24 | 1994-02-01 | The Procter & Gamble Company | Risedronate in oral compositions |
| ATE161423T1 (de) * | 1992-06-30 | 1998-01-15 | Procter & Gamble Pharma | Verwendung von phosphinate zur behandlung der osteoporose |
| AU4407493A (en) * | 1992-08-07 | 1994-03-03 | Upjohn Company, The | Phosphonoacetic esters and acids as anti-inflammatories |
| US5358941A (en) * | 1992-12-02 | 1994-10-25 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids with lactose |
| TW401276B (en) * | 1993-10-07 | 2000-08-11 | Zeneca Ltd | Novel compounds and a method of controlling growth of plants |
| US5728650A (en) * | 1993-10-07 | 1998-03-17 | Zeneca Limited | Herbicidal aza bisphosphonic acids and compositions containing the same |
| US5880111A (en) * | 1995-06-07 | 1999-03-09 | Farcasiu; Dan | Therapeutic derivations of diphosphonates |
| AU2005227418B2 (en) * | 1997-07-22 | 2008-05-29 | Merck Sharp & Dohme Corp. | Method for inhibiting bone resorption |
| US6432932B1 (en) | 1997-07-22 | 2002-08-13 | Merck & Co., Inc. | Method for inhibiting bone resorption |
| PL195272B1 (pl) * | 1997-07-22 | 2007-08-31 | Merck & Co Inc | Zastosowania kwasu alendronowego lub jego farmaceutycznie dopuszczalnej soli lub ich mieszaniny |
| AU2007211965B2 (en) * | 1997-07-22 | 2008-05-15 | Merck Sharp & Dohme Corp. | Alendronate for use in the treatment of osteoporosis |
| US6015801A (en) * | 1997-07-22 | 2000-01-18 | Merck & Co., Inc. | Method for inhibiting bone resorption |
| US5994329A (en) | 1997-07-22 | 1999-11-30 | Merck & Co., Inc. | Method for inhibiting bone resorption |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4330530A (en) * | 1980-12-22 | 1982-05-18 | The Procter & Gamble Company | Anti-arthritic compositions and method using gold salts and organophosphonates |
| FR2531088B1 (fr) * | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
| FR2558837B1 (fr) * | 1984-01-26 | 1986-06-27 | Sanofi Sa | Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant |
| PH27078A (en) * | 1984-12-21 | 1993-02-01 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonates |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| DE3640938A1 (de) * | 1986-11-29 | 1988-06-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel |
-
1987
- 1987-12-07 IL IL84731A patent/IL84731A0/xx not_active IP Right Cessation
- 1987-12-16 DE DE3789436T patent/DE3789436T2/de not_active Expired - Fee Related
- 1987-12-16 AT AT87202530T patent/ATE103286T1/de active
- 1987-12-16 EP EP87202530A patent/EP0274158B1/de not_active Expired - Lifetime
- 1987-12-17 CA CA000554627A patent/CA1321198C/en not_active Expired - Fee Related
- 1987-12-18 AU AU82694/87A patent/AU616391B2/en not_active Ceased
- 1987-12-18 IE IE345787A patent/IE61881B1/en not_active IP Right Cessation
- 1987-12-18 DK DK670487A patent/DK670487A/da not_active Application Discontinuation
- 1987-12-18 PH PH36261A patent/PH26154A/en unknown
- 1987-12-18 NZ NZ222986A patent/NZ222986A/en unknown
- 1987-12-19 ZA ZA879454A patent/ZA879454B/xx unknown
- 1987-12-19 KR KR1019870014560A patent/KR960001845B1/ko not_active IP Right Cessation
- 1987-12-19 JP JP62322652A patent/JPS63239291A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE3789436T2 (de) | 1994-08-25 |
| NZ222986A (en) | 1991-05-28 |
| AU616391B2 (en) | 1991-10-31 |
| IL84731A0 (en) | 1988-05-31 |
| ATE103286T1 (de) | 1994-04-15 |
| KR880007461A (ko) | 1988-08-27 |
| IE61881B1 (en) | 1994-11-30 |
| IE873457L (en) | 1988-06-19 |
| AU8269487A (en) | 1988-06-23 |
| KR960001845B1 (ko) | 1996-02-06 |
| JPS63239291A (ja) | 1988-10-05 |
| ZA879454B (en) | 1988-06-10 |
| PH26154A (en) | 1992-03-18 |
| EP0274158A1 (de) | 1988-07-13 |
| DK670487D0 (da) | 1987-12-18 |
| EP0274158B1 (de) | 1994-03-23 |
| CA1321198C (en) | 1993-08-10 |
| DK670487A (da) | 1988-06-20 |
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| Publication | Publication Date | Title |
|---|---|---|
| DE3789436D1 (de) | Heteroring-substituierte Diphosphonatverbindungen, Arzneimittel und Verfahren zur Behandlung von abnormalen Kalzium- und Phosphatmetabolismen. | |
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| DE68914292D1 (de) | Zusammensetzung zur Behandlung von ischämischen Störungen in Organen. | |
| IL80570A0 (en) | Diphosphonic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing them | |
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| ATE71629T1 (de) | Methylenphosphonalkylphosphinate, pharmazeutische zubereitungen und verfahren zur behandlung abnormalen kalzium- und phosphat-stoffwechsels. | |
| ATE88894T1 (de) | Methode zur behandlung von kachexie und bestimmte dafuer anzuwendende verbindungen. | |
| MY131193A (en) | 7-(2-aminoethyl)-benzothiazolones | |
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| ATE59046T1 (de) | Bizyklische diphosphonat-verbindungen und arzneimittel. | |
| ATE102195T1 (de) | Zyklische schwefelhaltige verbindungen. | |
| HUT57209A (en) | Process for producing hydroxymethyl-indolizidine and kinolizidine derivatives and pharmaceutical compositions containing them | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: PROCTER & GAMBLE PHARMACEUTICALS, NORWICH, N.Y., U |
|
| 8339 | Ceased/non-payment of the annual fee |