DE3785374D1 - Gegen eine substanz mit niedrigem molekulargewicht spezifischer antikoerper und verfahren zu seiner herstellung mittels kolloidaler metallteilchen als traeger. - Google Patents

Gegen eine substanz mit niedrigem molekulargewicht spezifischer antikoerper und verfahren zu seiner herstellung mittels kolloidaler metallteilchen als traeger.

Info

Publication number
DE3785374D1
DE3785374D1 DE8787100208T DE3785374T DE3785374D1 DE 3785374 D1 DE3785374 D1 DE 3785374D1 DE 8787100208 T DE8787100208 T DE 8787100208T DE 3785374 T DE3785374 T DE 3785374T DE 3785374 D1 DE3785374 D1 DE 3785374D1
Authority
DE
Germany
Prior art keywords
molecular weight
substance
metal particles
colloidal metal
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787100208T
Other languages
English (en)
Other versions
DE3785374T2 (de
Inventor
Shiosaka Sadao
Johji Kohno
Hiroshi Kiyama
Masaya Tohyama
Yahe Shiotani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE3785374D1 publication Critical patent/DE3785374D1/de
Publication of DE3785374T2 publication Critical patent/DE3785374T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
    • G01N2474/20—Immunohistochemistry assay

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Colloid Chemistry (AREA)
DE87100208T 1986-01-10 1987-01-09 Gegen eine Substanz mit niedrigem Molekulargewicht spezifischer Antikörper und Verfahren zu seiner Herstellung mittels kolloidaler Metallteilchen als Träger. Expired - Fee Related DE3785374T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61003825A JPS62162963A (ja) 1986-01-10 1986-01-10 金属コロイド粒子を担体とする低分子物質に対する特異抗体の作成法

Publications (2)

Publication Number Publication Date
DE3785374D1 true DE3785374D1 (de) 1993-05-19
DE3785374T2 DE3785374T2 (de) 1993-10-14

Family

ID=11567970

Family Applications (1)

Application Number Title Priority Date Filing Date
DE87100208T Expired - Fee Related DE3785374T2 (de) 1986-01-10 1987-01-09 Gegen eine Substanz mit niedrigem Molekulargewicht spezifischer Antikörper und Verfahren zu seiner Herstellung mittels kolloidaler Metallteilchen als Träger.

Country Status (6)

Country Link
US (1) US5112606A (de)
EP (1) EP0232717B1 (de)
JP (1) JPS62162963A (de)
AT (1) ATE88277T1 (de)
DE (1) DE3785374T2 (de)
ES (1) ES2054621T3 (de)

Families Citing this family (31)

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US5972656A (en) * 1989-03-14 1999-10-26 Bionebraska, Inc. Mercury binding polypeptides and nucleotides coding therefore
US5639624A (en) * 1989-03-14 1997-06-17 Board Of Regents Of The University Of Nebraska Monoclonal antibodies specific for metallic cations and method therefor
WO1992004633A1 (en) * 1990-09-05 1992-03-19 Neurex Corporation Method and composition for detecting bioactive peptides
US5965379A (en) * 1991-07-19 1999-10-12 Cytimmune Sciences Inc. Method for measuring endogenous cytokines
ATE184703T1 (de) * 1991-07-19 1999-10-15 Cytimmune Sciences Inc Verfahren und testsatz zur messung von endogenen zytokinen
US5679350A (en) * 1992-05-28 1997-10-21 The University Of Toledo Method of delivery of a medicament to a cancer cell using a pathway of plasminogen activator material
US6274552B1 (en) 1993-03-18 2001-08-14 Cytimmune Sciences, Inc. Composition and method for delivery of biologically-active factors
ATE270111T1 (de) * 1993-03-18 2004-07-15 Cytimmune Sciences Inc Zusammensetzung und methode zur reduktion der toxizität von biologisch-aktiven faktoren
US5532136A (en) * 1993-06-22 1996-07-02 Bionebraska, Inc. Monoclonal antibody assay and kit for detecting metal cations in body fluids
US20010055581A1 (en) * 1994-03-18 2001-12-27 Lawrence Tamarkin Composition and method for delivery of biologically-active factors
US6111079A (en) * 1995-06-05 2000-08-29 Bionebraska, Inc. Lead binding polypeptides and nucleotides coding therefore
WO1997042220A1 (en) * 1996-05-03 1997-11-13 Thomas Jefferson University Metastatic colorectal cancer vaccine
US6767704B2 (en) 2000-03-27 2004-07-27 Thomas Jefferson University Methods of screening and diagnosing esophageal cancer by determining guanylin cyclase C expression
US7135333B1 (en) 1997-08-07 2006-11-14 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
US6120995A (en) * 1997-08-07 2000-09-19 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
US6407218B1 (en) 1997-11-10 2002-06-18 Cytimmune Sciences, Inc. Method and compositions for enhancing immune response and for the production of in vitro mabs
WO1999024066A2 (en) * 1997-11-10 1999-05-20 Cytimmune Sciences, Inc. Methods and compositions for enhancing immune response and for the production of in vitro mabs
US7229841B2 (en) * 2001-04-30 2007-06-12 Cytimmune Sciences, Inc. Colloidal metal compositions and methods
WO2002022885A1 (en) * 2000-09-18 2002-03-21 Thomas Jefferson University Compositions and methods for identifying and targeting stomach and esophageal cancer cells
US20060052592A1 (en) * 2002-06-20 2006-03-09 Levinson Arnold I Vaccines for suppressing ige-mediated allergic disease and methods for using the same
US20050175583A1 (en) * 2003-12-02 2005-08-11 Lawrence Tamarkin Methods and compositions for the production of monoclonal antibodies
EP1715971A4 (de) * 2004-01-28 2010-10-13 Cytimmune Sciences Inc Funktionalisierte kolloidale metallzusammensetzungen und verfahren
JP4735954B2 (ja) * 2005-06-03 2011-07-27 独立行政法人産業技術総合研究所 抗体産生キャリア
US20080206276A1 (en) 2005-07-08 2008-08-28 Michael Otto Targeting Poly-Gamma-Glutamic Acid to Treat Staphylococcus Epidermidis and Related Infections
US20110014118A1 (en) * 2007-09-21 2011-01-20 Lawrence Tamarkin Nanotherapeutic colloidal metal compositions and methods
CA2700378A1 (en) * 2007-09-21 2009-03-29 Cytimmune Sciences, Inc. Nanotherapeutic colloidal metal compositions and methods
US7960145B2 (en) * 2007-11-08 2011-06-14 Cytimmune Sciences, Inc. Compositions and methods for generating antibodies
US20110206736A1 (en) * 2008-09-23 2011-08-25 Thomas Jefferson University Cancer Vaccines Against Mucosal Antigens and Methods of Making and Using the Same
DE102009040870B4 (de) * 2009-09-09 2016-10-13 Manfred Sietz Modifiziertes kolloidales Edelmetall zur Behandlung und Prophylaxe von Krankheiten
EP2491116A4 (de) 2009-10-22 2013-12-11 Univ Jefferson Zellbasierte antikrebszusammensetzungen sowie verfahren zu ihrer herstellung und verwendung
CN104780938A (zh) 2012-08-02 2015-07-15 小利兰·斯坦福大学托管委员会 用于肿瘤治疗的基于EGFRvIII序列的肽疫苗

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1492010A1 (de) * 1961-10-06 1969-07-17 Mack Chem Pharm Verfahren zur Herstellung von zur Desensibilisierung von Allergosen geeigneten Stoffen
GB981242A (en) * 1961-10-19 1965-01-20 Wellcome Found Vaccines containing rare earth salts
DE1945251A1 (de) * 1969-09-06 1971-03-11 Karl Dr Med Theurer Verfahren zur Beeinflussung der quantitativen Antikoerperbildung bei der aktiven Immunisierung und der Desensibilisierung
US4016252A (en) * 1972-04-06 1977-04-05 Institut Pasteur Calcium phosphate gel for adsorbing vaccines
US4197237A (en) * 1973-06-01 1980-04-08 Syva Company Antibodies to nitrogen derivatives of benzoyl ecgonine antigenic conjugates thereof
US3919413A (en) * 1973-10-12 1975-11-11 Univ Nebraska Vaccine for neonatal calf diarrhea
US4218436A (en) * 1977-09-21 1980-08-19 The Upjohn Company Compounds and methods
US4197286A (en) * 1977-09-27 1980-04-08 Southwest Research Institute Testosterone derivatives and assay method
US4196185A (en) * 1978-06-05 1980-04-01 Hoffmann-La Roche Inc. Immunoassay for phencyclidine
US4329281A (en) * 1978-06-05 1982-05-11 Hoffmann-La Roche Inc. Hapten compositions
US4215036A (en) * 1978-08-15 1980-07-29 Research Corporation Modified grass pollen antigens
DE2964721D1 (en) * 1978-08-24 1983-03-17 Nat Res Dev Pasteurellosis vaccines
US4213964A (en) * 1978-12-07 1980-07-22 Miles Laboratories, Inc. Diphenylhydantoin antibodies
US4332787A (en) * 1980-06-23 1982-06-01 The Massachusetts General Hospital Assay for beta-adrenergic antagonists and antibody therefor
US4608252A (en) * 1981-04-23 1986-08-26 Syntex (U.S.A.) Inc. Chloramphenicol derivatives antigens and antibodies
FR2533827A1 (fr) * 1982-09-30 1984-04-06 Anvar Composition possedant des proprietes immunoregulatrices, notamment d'adjuvants immunologiques non specifiques, a base de muramylpeptide et d'un derive d'aluminium
HU188847B (en) * 1983-02-22 1986-05-28 Human Oltoanyagtermeloe Es Kutato Intezet,Hu Process for producing liophylized combined vaccines
NO162241C (no) * 1983-06-14 1989-11-29 Roussel Uclaf Nye, radioaktive estradienderivater merket med jod125, fremgangsmaate ved deres fremstilling og deres anvendelse vedradioimmunologisk undersoekelse og mengdebestemmelse av steroider i biologiske vaesker.
JPS60193925A (ja) * 1984-03-13 1985-10-02 Chemo Sero Therapeut Res Inst 凍結乾燥製剤化ワクチン

Also Published As

Publication number Publication date
ATE88277T1 (de) 1993-04-15
EP0232717B1 (de) 1993-04-14
DE3785374T2 (de) 1993-10-14
US5112606A (en) 1992-05-12
EP0232717A3 (en) 1989-02-15
JPS62162963A (ja) 1987-07-18
EP0232717A2 (de) 1987-08-19
JPH0584467B2 (de) 1993-12-02
ES2054621T3 (es) 1994-08-16

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