DE3777747D1 - Pro-drug-derivate vom kardiotonischen agenz 4-ethyl-1,3-dihydro-5(4-(2-methyl-1h-imidazol-1-yl)-benzoyl))-2h-imidazol-one. - Google Patents
Pro-drug-derivate vom kardiotonischen agenz 4-ethyl-1,3-dihydro-5(4-(2-methyl-1h-imidazol-1-yl)-benzoyl))-2h-imidazol-one.Info
- Publication number
- DE3777747D1 DE3777747D1 DE8787114724T DE3777747T DE3777747D1 DE 3777747 D1 DE3777747 D1 DE 3777747D1 DE 8787114724 T DE8787114724 T DE 8787114724T DE 3777747 T DE3777747 T DE 3777747T DE 3777747 D1 DE3777747 D1 DE 3777747D1
- Authority
- DE
- Germany
- Prior art keywords
- imidazol
- dihydro
- benzoyl
- ethyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/920,086 US4743612A (en) | 1986-10-17 | 1986-10-17 | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-(4-(2-methyl-1H-imidazol-1-yl)benzoyl)-2H-imidazol-2-one, composition containing them, and method of using them to treat cardiac failure |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3777747D1 true DE3777747D1 (de) | 1992-04-30 |
Family
ID=25443129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787114724T Expired - Lifetime DE3777747D1 (de) | 1986-10-17 | 1987-10-08 | Pro-drug-derivate vom kardiotonischen agenz 4-ethyl-1,3-dihydro-5(4-(2-methyl-1h-imidazol-1-yl)-benzoyl))-2h-imidazol-one. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4743612A (de) |
EP (1) | EP0264729B1 (de) |
JP (1) | JPS63104964A (de) |
AT (1) | ATE74130T1 (de) |
CA (1) | CA1325213C (de) |
DE (1) | DE3777747D1 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5360928A (en) * | 1989-10-23 | 1994-11-01 | Research Corporation Technologies, Inc. | Synthesis and use of amino acid fluorides as peptide coupling reagents |
US5712418A (en) | 1989-10-23 | 1998-01-27 | Research Corporation Technologies, Inc. | Synthesis and use of amino acid fluorides as peptide coupling reagents |
US5939557A (en) * | 1996-04-03 | 1999-08-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
GB9613470D0 (en) * | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5976069A (ja) * | 1982-10-25 | 1984-04-28 | Showa Denko Kk | フタラゾン誘導体 |
US4552880A (en) * | 1983-02-15 | 1985-11-12 | Merrell Dow Pharmaceuticals Inc. | Aroylimidazolones |
US4556665A (en) * | 1984-07-09 | 1985-12-03 | Schering A.G. | Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones |
EP0195582B1 (de) * | 1985-03-14 | 1990-01-24 | SMITH KLINE DAUELSBERG GmbH | 5-Aminosalicylsäurederivate von nicht-steroidalen entzündungshemmenden Sauren |
-
1986
- 1986-10-17 US US06/920,086 patent/US4743612A/en not_active Expired - Fee Related
-
1987
- 1987-09-17 CA CA000547106A patent/CA1325213C/en not_active Expired - Fee Related
- 1987-10-08 EP EP87114724A patent/EP0264729B1/de not_active Expired - Lifetime
- 1987-10-08 AT AT87114724T patent/ATE74130T1/de not_active IP Right Cessation
- 1987-10-08 DE DE8787114724T patent/DE3777747D1/de not_active Expired - Lifetime
- 1987-10-14 JP JP62259445A patent/JPS63104964A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ATE74130T1 (de) | 1992-04-15 |
EP0264729A3 (en) | 1989-10-11 |
CA1325213C (en) | 1993-12-14 |
EP0264729A2 (de) | 1988-04-27 |
JPS63104964A (ja) | 1988-05-10 |
EP0264729B1 (de) | 1992-03-25 |
US4743612A (en) | 1988-05-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |