DE3777184D1 - Leukotrien-antagonisten. - Google Patents

Leukotrien-antagonisten.

Info

Publication number
DE3777184D1
DE3777184D1 DE8787309553T DE3777184T DE3777184D1 DE 3777184 D1 DE3777184 D1 DE 3777184D1 DE 8787309553 T DE8787309553 T DE 8787309553T DE 3777184 T DE3777184 T DE 3777184T DE 3777184 D1 DE3777184 D1 DE 3777184D1
Authority
DE
Germany
Prior art keywords
alkyl
alkoxy
phenyl
pco2h
co2h
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787309553T
Other languages
English (en)
Inventor
John Gerald Gleason
Ralph Floyd Hall
Wen-Fu Ku Thomas
Carl David Perchonock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of DE3777184D1 publication Critical patent/DE3777184D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8787309553T 1987-10-29 1987-10-29 Leukotrien-antagonisten. Expired - Lifetime DE3777184D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87309553A EP0313697B1 (de) 1987-10-29 1987-10-29 Leukotrien-Antagonisten

Publications (1)

Publication Number Publication Date
DE3777184D1 true DE3777184D1 (de) 1992-04-09

Family

ID=8198080

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787309553T Expired - Lifetime DE3777184D1 (de) 1987-10-29 1987-10-29 Leukotrien-antagonisten.

Country Status (8)

Country Link
EP (1) EP0313697B1 (de)
JP (1) JPH01135762A (de)
AT (1) ATE73132T1 (de)
AU (1) AU610528B2 (de)
DE (1) DE3777184D1 (de)
ES (1) ES2033322T3 (de)
GR (1) GR3004298T3 (de)
ZA (1) ZA878085B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954513A (en) * 1988-12-23 1990-09-04 Smithkline Beecham Corporation Leukotriene antagonists
CA2018437A1 (en) * 1989-06-14 1990-12-14 James Simpson Frazee Leukotriene antagonists
EP0541706B1 (de) * 1990-08-01 1995-09-13 Smithkline Beecham Corporation Verfahren und zwischenprodukte für die herstellung von 2-hydroxy-3-sulfido-3-phenylpropansäuren
IE913308A1 (en) * 1990-09-21 1992-02-25 Smithkline Beecham Corp Crystallization of optical isomers of leukotriene¹antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513005A (en) * 1981-06-18 1985-04-23 Lilly Industries Limited SRS-A antagonists
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
US4755524A (en) * 1986-01-31 1988-07-05 G. D. Searle & Co. Novel phenolic thioethers as inhibitors of 5-lipoxygenase

Also Published As

Publication number Publication date
AU610528B2 (en) 1991-05-23
ZA878085B (en) 1988-06-27
AU8017187A (en) 1989-04-27
ATE73132T1 (de) 1992-03-15
EP0313697B1 (de) 1992-03-04
GR3004298T3 (de) 1993-03-31
JPH01135762A (ja) 1989-05-29
EP0313697A1 (de) 1989-05-03
ES2033322T3 (es) 1993-03-16

Similar Documents

Publication Publication Date Title
ES2039522T3 (es) Procedimiento para preparar un nuevo benzotiazol.
AR241414A1 (es) Procedimiento para la preparacion de derivados de 2,2'-iminobisetanol y obtencion de intermediarios.
EA199800538A1 (ru) Производные хинолин-4-карбоксамида, их получение и их применение в качестве антагонистов рецептора нейрокинина-3 (-к-3) и нейрокинина-2 (-к-2)
RU2000128033A (ru) Гетероциклические производные глицил-бета-аланина в качестве антагонистов витронектина
ATE380818T1 (de) Piperazine-substituierte aryl-benzodiazepinen und ihre verwendung als dopaminrezeptor-antagonisten zur behandlung von psychose
ES554895A0 (es) Un procedimiento para preparar derivados de (benzoil-4-piperidinil-1)-2-fenil-1-alcanoles
AR004706A1 (es) Un compuesto derivado de benzoxazina y pirido-oxazina utiles como antimicrobianos, composicion farmaceutica que lo contienen, un metodo para preparar dichos compuestos e intermediarios utiles para dicho metodo.
ATE365715T1 (de) Benzo(f)isoindolderivate mit affinität zum ep4- rezeptor
CO4950515A1 (es) Nuevos derivados de la quinolina para uso medicinal
DE3777184D1 (de) Leukotrien-antagonisten.
DK0677042T3 (da) Selektive ligander af 5HT1D-5HT1B-receptorer, der er afledt af indolpiperazin og er nyttige som lægemidler
FI830831A0 (fi) Teofyllinyl-alkyl-oxadiazoler, foerfarande foer framstaellning daerav och farmaceutiska kompositioninnehaollande dessa
FI925501A (fi) Imidazolfoereningar, deras framstaellning och anvaendning
SE8303987L (sv) N-fenylpyrazolderivat anvendbara som herbicider
ATE95816T1 (de) 2-((4-piperidinyl)methyl>-1,2,3,4tetrahydroisochinolin-derivate, ihre herstellung und ihre therapeutische verwendung.
PT86027A (en) Leukotriene antagonists
ATE129700T1 (de) Beta-phenoxynitril-verbindungen.
DE69512364D1 (de) Naphthalen-Derivate und ihre Verwendung als PGE- Agonisten und Antagonisten
ES2076959T3 (es) Nuevos derivados de amino acidos.
ES2193385T3 (es) Inhibidores tiadiazol amida de la metaloproteasa.
FI870254A (fi) Foerfarande foer framstaellning av 3-acylaminometylimidazo/1,2-a/pyridiner.
CO4700450A1 (es) Nuevos azepanos y homologos de su anillo
DE69011714D1 (de) Kalziumantagonisten.
ES8604500A2 (es) Procedimiento de obtencion de de nuevas sulfonamidinas
AR016785A1 (es) 1-fenil-4-bencilpiperazinas: ligandos especificos de los subtipos de los receptores de dopamina

Legal Events

Date Code Title Description
8364 No opposition during term of opposition