ES2033322T3 - Procedimiento para preparar antagonistas de leucotrieno. - Google Patents

Procedimiento para preparar antagonistas de leucotrieno.

Info

Publication number
ES2033322T3
ES2033322T3 ES198787309553T ES87309553T ES2033322T3 ES 2033322 T3 ES2033322 T3 ES 2033322T3 ES 198787309553 T ES198787309553 T ES 198787309553T ES 87309553 T ES87309553 T ES 87309553T ES 2033322 T3 ES2033322 T3 ES 2033322T3
Authority
ES
Spain
Prior art keywords
preparing
procedure
antagonists
leucotrene
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787309553T
Other languages
English (en)
Inventor
John Gerald Gleason
Ralph Floyd Hall
Wen-Fu Ku Thomas
Carl David Perchonock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of ES2033322T3 publication Critical patent/ES2033322T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

ESTA INVENCION ESTA RELACIONADA CON COMPUESTO DE ACIDO ALCANOICO TENIENDO SUBSTITUYENTES FENIL Y SULFINIL O SULFONIL EN CUALES SON UTILES COMO ANTAGONISTAS DEL LENCOTRIENO Y CON COMPOSICIONES FARMACEUTICAS CONTENIENDO TALES COMPUESTOS. EL INVENTO TAMBIEN ESTA RELACIONADO CON EL USO DE TAL COMPUESTO PARA EL TRATAMIENTO DE ENFERMEDADES EN LAS QUE EN LENCOTRIENOS SON UN FACTOR.
ES198787309553T 1987-10-29 1987-10-29 Procedimiento para preparar antagonistas de leucotrieno. Expired - Lifetime ES2033322T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87309553A EP0313697B1 (en) 1987-10-29 1987-10-29 Leukotriene antagonists

Publications (1)

Publication Number Publication Date
ES2033322T3 true ES2033322T3 (es) 1993-03-16

Family

ID=8198080

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787309553T Expired - Lifetime ES2033322T3 (es) 1987-10-29 1987-10-29 Procedimiento para preparar antagonistas de leucotrieno.

Country Status (8)

Country Link
EP (1) EP0313697B1 (es)
JP (1) JPH01135762A (es)
AT (1) ATE73132T1 (es)
AU (1) AU610528B2 (es)
DE (1) DE3777184D1 (es)
ES (1) ES2033322T3 (es)
GR (1) GR3004298T3 (es)
ZA (1) ZA878085B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954513A (en) * 1988-12-23 1990-09-04 Smithkline Beecham Corporation Leukotriene antagonists
CA2018437A1 (en) * 1989-06-14 1990-12-14 James Simpson Frazee Leukotriene antagonists
ATE127784T1 (de) * 1990-08-01 1995-09-15 Smithkline Beecham Corp Verfahren und zwischenprodukte für die herstellung von 2-hydroxy-3-sulfido-3- phenylpropansäuren.
CA2091245A1 (en) * 1990-09-21 1992-03-22 Trevor Laird Crystallization of optical isomers of leukotriene antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513005A (en) * 1981-06-18 1985-04-23 Lilly Industries Limited SRS-A antagonists
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
US4755524A (en) * 1986-01-31 1988-07-05 G. D. Searle & Co. Novel phenolic thioethers as inhibitors of 5-lipoxygenase

Also Published As

Publication number Publication date
AU610528B2 (en) 1991-05-23
AU8017187A (en) 1989-04-27
EP0313697B1 (en) 1992-03-04
DE3777184D1 (de) 1992-04-09
ZA878085B (en) 1988-06-27
JPH01135762A (ja) 1989-05-29
GR3004298T3 (es) 1993-03-31
EP0313697A1 (en) 1989-05-03
ATE73132T1 (de) 1992-03-15

Similar Documents

Publication Publication Date Title
NO905608L (no) Fremgangsmaate for fremstilling av a-nor-steroid-3-karboksylsyrederivater.
SE8100978L (sv) Kinolinkarboxylsyraderivat och sett for framstellning derav
NL930095I1 (nl) Aromatische heterocyclische esters van steroïden de bereiding daarvan en farmaceutische composities die deze verbindingen bevatten
EP0397697A4 (en) Quinoline derivatives as antagonists of leukotriene d 4?
KR870700599A (ko) 카르복실산유도체, 그의 제조방법, 이화합물을 함유한 약제조성물 및 그의 용도
PT97395A (pt) Processo para a preparacao de 2,9-di-substituidas-4h-pirido{1,2-a}-pirimidin-4-onas e de composicoes farmaceuticas que os contem
PT88503A (pt) Procede pour la preparation de derives de (benzyl piperidino)-1propanol-2
IL62198A0 (en) 3,4,5-trihydroxypiperidine compounds,their production and pharmaceutical compositions containing them
MA21902A1 (fr) Procede pour la preparation de peptitides hemoregulateurs et des compositions pharmaceutiques les comtenant .
NO161492C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-cyklopropyl-6-fluor-1,4-dihydro-4-okso-7-(4-(oksoalkyl)-1-piperazinyl)-3-kinolinkarboksylsyre.
ATE124681T1 (de) Arzneimittelzusammensetzungen zur behandlung von psoriasis.
IL79910A (en) 5,7-dihydro-6-(thi)oxopyrrolo(2,3-f)benzimidazole,-benzothiazole and-benzoxazoles,6-imines thereof,their preparation and pharmaceutical compositions containing them
SE8600658D0 (sv) Novel composition of matter
BR9502062A (pt) Composto processo para a sua preparaçao e composiçao farmaceutica
ES2033322T3 (es) Procedimiento para preparar antagonistas de leucotrieno.
AR222039A1 (es) Amidas de acidos 1,2,3-triazol-carboxilicos,procedimientos para la produccion de estos compuestos y composiciones biocidas que los contienen
ES2075137T3 (es) Compuestos sustituidos de piridina; su produccion y composiciones farmaceuticas que los contienen.
SE8604838L (sv) Farmaceutiska kompositioner
ATE167869T1 (de) Thiolderivate von gallensäure
ES2053808T3 (es) Nuevos compuestos azolicos.
DK0381114T3 (da) Exo-3,4-O-benzyliden-3"-demethylchartreusin og salte deraf
PT71725A (de) 2-(2-chlor-4-cyclopropyl-phenyl-imino)-imidazolidin dessensaureadditionssalze diese enthaltende arzneimittel und verfahren zur herstellung derselben
IT9021967A0 (it) Composizioni farmaceutiche contenenti acido 2-(2-pirrolidon-5-carbonilamido)-3-mercaptopropionico, per il trattamento di malattie connesse auna carenza di glutatione
ES2037855T3 (es) Procedimiento para preparar nuevos derivados de 1-bencil-2-oxo-5-alcoxi-pirrolidina.
EP0337765A3 (en) Acylsulfonamide derivatives of alpha-carbocyclyltoluic acids used as leukotriene antagonists

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 313697

Country of ref document: ES