DE3765808D1 - Heterocyclische tetrahydro-3,4-diamin-n-n'-platin-komplexe. - Google Patents

Heterocyclische tetrahydro-3,4-diamin-n-n'-platin-komplexe.

Info

Publication number
DE3765808D1
DE3765808D1 DE8787102447T DE3765808T DE3765808D1 DE 3765808 D1 DE3765808 D1 DE 3765808D1 DE 8787102447 T DE8787102447 T DE 8787102447T DE 3765808 T DE3765808 T DE 3765808T DE 3765808 D1 DE3765808 D1 DE 3765808D1
Authority
DE
Germany
Prior art keywords
tetrahydro
diamine
heterocyclic
platinum complexes
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787102447T
Other languages
English (en)
Inventor
Panayota Bitha
Ralph Grassing Child
Joseph John Hlavka
Yang-I Lin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DE3765808D1 publication Critical patent/DE3765808D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8787102447T 1986-03-20 1987-02-20 Heterocyclische tetrahydro-3,4-diamin-n-n'-platin-komplexe. Expired - Fee Related DE3765808D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/841,647 US4716157A (en) 1986-03-20 1986-03-20 Heterocyclic-1,2-diamine platinum complexes

Publications (1)

Publication Number Publication Date
DE3765808D1 true DE3765808D1 (de) 1990-12-06

Family

ID=25285372

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787102447T Expired - Fee Related DE3765808D1 (de) 1986-03-20 1987-02-20 Heterocyclische tetrahydro-3,4-diamin-n-n'-platin-komplexe.

Country Status (8)

Country Link
US (1) US4716157A (de)
EP (1) EP0237829B1 (de)
JP (1) JPS62289591A (de)
AT (1) ATE57933T1 (de)
CA (1) CA1282060C (de)
DE (1) DE3765808D1 (de)
ES (1) ES2020953B3 (de)
GR (1) GR3001035T3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116831A (en) * 1985-12-24 1992-05-26 Warner-Lambert Company Aminoalkyl-substituted cycloalkylamine platinum (II) complexes
US4970324A (en) * 1985-12-24 1990-11-13 Hoeschele James D Aminoalkyl-substituted azetidine platinum(II) complexes
US4870070A (en) * 1987-08-10 1989-09-26 American Cyanamid Company Water soluble platinum complexes of novel malonate derivatives
US5041578A (en) * 1988-11-22 1991-08-20 Board Of Regents, The University Of Texas System Water soluble 1,2-diaminocyclohexane platinum (IV) complexes as antitumor agents
US5434256A (en) * 1988-11-22 1995-07-18 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
KR920701221A (ko) * 1989-12-15 1992-08-11 쓰무라 아끼라 신규한 백금 착체 및 이를 유효성분으로 하는 항종양제
JPH09316065A (ja) * 1996-05-31 1997-12-09 Nikko Rika Kk １，４−アンヒドロ−２−デオキシ−ｄ−エリトロ−ペンチトールの製造法
DE10226592B4 (de) * 2002-06-14 2004-07-29 Faustus Forschungs Cie. Translational Cancer Research Gmbh Tumorhemmende Platin(II)-oxalato-Komplexe
US8895610B1 (en) 2007-05-18 2014-11-25 Heldi Kay Platinum (IV) compounds targeting zinc finger domains
US8026382B2 (en) 2007-05-18 2011-09-27 Heidi Kay Lipid raft, caveolin protein, and caveolar function modulation compounds and associated synthetic and therapeutic methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115418A (en) * 1976-09-02 1978-09-19 Government Of The United States Of America 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity
NL7807334A (nl) * 1978-07-06 1980-01-08 Tno Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een genees- middel met toepassing van een dergelijk platina-dia- minecomplex voor de behandeling van kanker, alsmede al- dus verkregen gevormd geneesmiddel.
NL8101026A (nl) * 1981-03-03 1982-10-01 Tno Platinadiamine-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiamine-complex voor de behandeling van kanker alsmede aldus verkregen gevormd geneesmiddel.
US4500465A (en) * 1982-06-28 1985-02-19 Engelhard Corporation Solubilized platinum (II) complexes
IL67789A (en) * 1983-01-31 1986-09-30 Yissum Res Dev Co Amino-substituted malonato platinum(ii)complexes and method for their preparation
US4661516A (en) * 1983-06-20 1987-04-28 Research Corporation Diaminocyclohexane platinum complexes
US4748254A (en) * 1984-01-23 1988-05-31 Institut Obschei I Neorganicheskoi Khimii Imeni N.S. Kurnakova Akademii Nauk SSR Mixed carboxylato platinum (II) complexes

Also Published As

Publication number Publication date
US4716157A (en) 1987-12-29
EP0237829B1 (de) 1990-10-31
GR3001035T3 (en) 1992-01-20
ATE57933T1 (de) 1990-11-15
JPS62289591A (ja) 1987-12-16
EP0237829A2 (de) 1987-09-23
CA1282060C (en) 1991-03-26
EP0237829A3 (en) 1988-01-07
ES2020953B3 (es) 1991-10-16

Similar Documents

Publication Publication Date Title
FI932032A0 (fi) Kinazolinderivat foer oekande av antitumoeraktivitet
FI872432A (fi) Indirekt kolorimetrisk bestaemning av en analyt i ett prov med hjaelp av ljussignalers foerhaollande.
DE59104440D1 (de) Epiduralkanüle.
DE3788525D1 (de) Feldeffekttransistoranordnungen.
DE3861931D1 (de) Gleitlagerhaelfte.
NL950021I2 (nl) 2-(Difluormethoxy)-1,1,1,2-tretrafluorethaan als anestheticum.
DE3765808D1 (de) Heterocyclische tetrahydro-3,4-diamin-n-n'-platin-komplexe.
DE69111768D1 (de) Enzymatische Zusammensetzung zur Bestimmung von Äthanol.
IT8820388A0 (it) Composizione oftalmologica.
FI904676A0 (fi) Anordning foer loesgoerande av manteln i en haeftapparat.
DE3870723D1 (de) Herstellung von ascorbinsaeure-6-estern.
DE3767728D1 (en) Hydroxylierte 1,2-diamincyclohexan platinkomplexe.
FI863006A0 (fi) Foerfarande foer framstaellning av metanol i en vaetskefas.
NO883070D0 (no) 4-aminosubstituerte 1,2-dihydroksynaftalin-derivater.
DE3851991D1 (de) Bipolartransistoren.
ATE83481T1 (de) Fuenfgliedrige heterocyclische derivate von n'substituiertenn,n'-diacylhydrazinen.
DE3788942D1 (de) Gleitteile.
ATE67992T1 (de) In 4-stellung durch stickstoff substituierte isochinolinolverbindungen mit cardiotonischen, die wirkung von phosphodiesterase-fraktion-iii inhibierenden und/oder renal vasodilatierenden eigenschaften.
EP0304566A3 (de) Wasserlösliche Platinkomplexe von Malonsäure-Derivaten
ES2024504B3 (es) Composicion desinfectante.
ES2053808T3 (es) Nuevos compuestos azolicos.
FI880733A (fi) Anordning foer uppbaerning av solv- eller rittgarn i en vaevstol.
SU1432991A1 (ru) 4-Метил-5-(4-метилфениламино)-1,2,3-триазол, обладающий противовоспалительной активностью
ATE102035T1 (de) Verwendung von 5-heteroaryl- oder 5arylsubstituierten imidazo(2,1-a)isochinolinen.
UA11675A1 (uk) 1-БЕtА-ОКСИЕТИЛАМІHО-3-КЕТО-5,5-ДИМЕТИЛЦИКЛОГЕКСЕH -1, ЯКИЙ МАЄ АHАЛЬГЕТИЧHУ АКТИВHІСТЬ

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee