DE3760422D1 - A process for the preparation of forskolin from 9-deoxy-forskolin and intermediates used therein - Google Patents

A process for the preparation of forskolin from 9-deoxy-forskolin and intermediates used therein

Info

Publication number
DE3760422D1
DE3760422D1 DE8787103939T DE3760422T DE3760422D1 DE 3760422 D1 DE3760422 D1 DE 3760422D1 DE 8787103939 T DE8787103939 T DE 8787103939T DE 3760422 T DE3760422 T DE 3760422T DE 3760422 D1 DE3760422 D1 DE 3760422D1
Authority
DE
Germany
Prior art keywords
beta
alpha
epoxy
forskolin
tetrahydroxylabd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8787103939T
Other languages
English (en)
Inventor
Nicholas J Hrib
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of DE3760422D1 publication Critical patent/DE3760422D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Shaping Of Tube Ends By Bending Or Straightening (AREA)
  • Steroid Compounds (AREA)
  • Excavating Of Shafts Or Tunnels (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Toys (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8787103939T 1986-03-31 1987-03-18 A process for the preparation of forskolin from 9-deoxy-forskolin and intermediates used therein Expired DE3760422D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/846,550 US4734513A (en) 1986-03-31 1986-03-31 Method of synthesizing forskolin from 9-deoxyforskolin

Publications (1)

Publication Number Publication Date
DE3760422D1 true DE3760422D1 (en) 1989-09-14

Family

ID=25298260

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787103939T Expired DE3760422D1 (en) 1986-03-31 1987-03-18 A process for the preparation of forskolin from 9-deoxy-forskolin and intermediates used therein

Country Status (13)

Country Link
US (1) US4734513A (de)
EP (1) EP0243646B1 (de)
JP (1) JPS62249981A (de)
KR (1) KR900007626B1 (de)
AT (1) ATE45353T1 (de)
AU (1) AU585143B2 (de)
DE (1) DE3760422D1 (de)
DK (1) DK159987A (de)
ES (1) ES2010511B3 (de)
GR (1) GR3000203T3 (de)
IL (1) IL82047A (de)
PT (1) PT84584B (de)
ZA (1) ZA872266B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008407A (en) * 1986-03-31 1991-04-16 Hoechst-Roussel Pharmaceuticals Inc. Method of synthesizing forskolin from 9-deoxyforskolin
US5070209A (en) * 1986-11-20 1991-12-03 Hoechst Roussel Pharmaceuticals Inc. 12-halogenated forskolin derivatives
US5023344A (en) * 1986-11-20 1991-06-11 Hoechst-Roussel Pharmaceuticals Incorporated 12-halogenated forskolin derivatives
US4978678A (en) * 1986-11-20 1990-12-18 Hoechst-Roussel Pharmaceuticals Inc. 12-halogenated forskolin derivatives
US4999351A (en) * 1989-01-11 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 7-aryl and heteroaryl ethers of desacetylforskolin
JP3557095B2 (ja) * 1998-04-20 2004-08-25 高砂香料工業株式会社 メラニン産生抑制剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2654796A1 (de) * 1976-12-03 1978-06-08 Hoechst Ag Polyoxygenierte labdan-derivate
US4517200A (en) * 1982-12-27 1985-05-14 Schering-Plough Corporation Method for treating allergic reactions with forskolin
US4564626A (en) * 1983-04-01 1986-01-14 Schering Corporation Methods of inducing bronchodilation
DE3407514A1 (de) * 1984-03-01 1985-09-26 Hoechst Ag, 6230 Frankfurt Verwendung von polyoxygenierten labdanderivaten zur behandlung von konstriktionen der atemwege
ATE60767T1 (de) * 1984-12-14 1991-02-15 Hoechst Roussel Pharma Aminoacyllabdane, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
US4639443A (en) * 1985-03-01 1987-01-27 Hoechst-Roussel Pharmaceuticals Inc. Labdane compounds, pharmaceutical compositions and use

Also Published As

Publication number Publication date
AU585143B2 (en) 1989-06-08
EP0243646A1 (de) 1987-11-04
PT84584B (pt) 1989-11-30
IL82047A0 (en) 1987-10-20
ES2010511B3 (es) 1989-11-16
DK159987A (da) 1987-10-01
KR870008908A (ko) 1987-10-21
US4734513A (en) 1988-03-29
IL82047A (en) 1992-02-16
GR3000203T3 (en) 1990-12-31
DK159987D0 (da) 1987-03-30
ZA872266B (en) 1987-11-25
PT84584A (en) 1987-04-01
EP0243646B1 (de) 1989-08-09
JPS62249981A (ja) 1987-10-30
AU7076587A (en) 1987-10-08
ATE45353T1 (de) 1989-08-15
KR900007626B1 (ko) 1990-10-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee