DE3735702A1 - Verfahren und vorrichtung zur beeinflussung von wachstum, teilung und differenzierung von zellen - Google Patents
Verfahren und vorrichtung zur beeinflussung von wachstum, teilung und differenzierung von zellenInfo
- Publication number
- DE3735702A1 DE3735702A1 DE19873735702 DE3735702A DE3735702A1 DE 3735702 A1 DE3735702 A1 DE 3735702A1 DE 19873735702 DE19873735702 DE 19873735702 DE 3735702 A DE3735702 A DE 3735702A DE 3735702 A1 DE3735702 A1 DE 3735702A1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- electrodes
- culture container
- culture
- electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 24
- 230000024245 cell differentiation Effects 0.000 title claims abstract description 14
- 230000008569 process Effects 0.000 title abstract description 5
- 238000004113 cell culture Methods 0.000 claims abstract description 10
- 239000004020 conductor Substances 0.000 claims abstract description 5
- 210000004027 cell Anatomy 0.000 claims description 41
- 210000001519 tissue Anatomy 0.000 claims description 14
- 230000010287 polarization Effects 0.000 claims description 13
- 230000002269 spontaneous effect Effects 0.000 claims description 10
- 210000000056 organ Anatomy 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 6
- 230000005684 electric field Effects 0.000 claims description 5
- 241000894006 Bacteria Species 0.000 claims description 3
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 239000003990 capacitor Substances 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- 239000011147 inorganic material Substances 0.000 claims description 3
- GQYHUHYESMUTHG-UHFFFAOYSA-N lithium niobate Chemical compound [Li+].[O-][Nb](=O)=O GQYHUHYESMUTHG-UHFFFAOYSA-N 0.000 claims description 3
- 229910044991 metal oxide Inorganic materials 0.000 claims description 3
- 150000004706 metal oxides Chemical class 0.000 claims description 3
- 229920001817 Agar Polymers 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 239000008272 agar Substances 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 238000005259 measurement Methods 0.000 claims description 2
- 239000011368 organic material Substances 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims description 2
- 229920001059 synthetic polymer Polymers 0.000 claims description 2
- 229940070527 tourmaline Drugs 0.000 claims description 2
- 229910052613 tourmaline Inorganic materials 0.000 claims description 2
- 239000011032 tourmaline Substances 0.000 claims description 2
- 239000012811 non-conductive material Substances 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108010076876 Keratins Proteins 0.000 claims 1
- 102000011782 Keratins Human genes 0.000 claims 1
- 102000029749 Microtubule Human genes 0.000 claims 1
- 108091022875 Microtubule Proteins 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 210000003050 axon Anatomy 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 210000003632 microfilament Anatomy 0.000 claims 1
- 210000004688 microtubule Anatomy 0.000 claims 1
- 230000000877 morphologic effect Effects 0.000 claims 1
- 229920005615 natural polymer Polymers 0.000 claims 1
- 210000005044 neurofilament Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 241000282414 Homo sapiens Species 0.000 description 3
- 230000004069 differentiation Effects 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000003313 weakening effect Effects 0.000 description 2
- 241000282412 Homo Species 0.000 description 1
- 229910013641 LiNbO 3 Inorganic materials 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000019552 anatomical structure morphogenesis Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012777 electrically insulating material Substances 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005616 pyroelectricity Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 210000002265 sensory receptor cell Anatomy 0.000 description 1
- 102000027509 sensory receptors Human genes 0.000 description 1
- 108091008691 sensory receptors Proteins 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873735702 DE3735702A1 (de) | 1987-09-08 | 1987-10-22 | Verfahren und vorrichtung zur beeinflussung von wachstum, teilung und differenzierung von zellen |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3730076 | 1987-09-08 | ||
| DE19873735702 DE3735702A1 (de) | 1987-09-08 | 1987-10-22 | Verfahren und vorrichtung zur beeinflussung von wachstum, teilung und differenzierung von zellen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3735702A1 true DE3735702A1 (de) | 1989-03-16 |
| DE3735702C2 DE3735702C2 (enrdf_load_stackoverflow) | 1989-06-22 |
Family
ID=25859541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19873735702 Granted DE3735702A1 (de) | 1987-09-08 | 1987-10-22 | Verfahren und vorrichtung zur beeinflussung von wachstum, teilung und differenzierung von zellen |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE3735702A1 (enrdf_load_stackoverflow) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0791651A1 (de) * | 1996-01-31 | 1997-08-27 | IPR-Institute for Pharmaceutical Research Riehen AG | Method zur Behandelung von biologischem Material |
| WO2000049173A3 (de) * | 1999-02-15 | 2002-01-31 | Fraunhofer Ges Forschung | Verfahren und probenträgersystem zur trennung und anreicherung von stoffen in situ |
| WO2001046692A3 (de) * | 1999-12-20 | 2002-02-14 | Forschungszentrum Juelich Gmbh | Messverfahren unter einsatz mindestens einer biologischen rezeptorzelle sowie eine zur durchführung des messverfahrens geeignete vorrichtung |
| WO2007004073A3 (en) * | 2005-04-19 | 2008-03-27 | Consiglio Nazionale Ricerche | Apparatus for culturing eucaryotic and/or procaryotic cells |
| EP2126069A4 (en) * | 2007-02-16 | 2010-05-26 | Iogenyx Pty Ltd | METHODS FOR IMPROVING CULTURE OF AQUATIC ORGANISMS |
| WO2013117193A1 (de) | 2012-02-09 | 2013-08-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V. | Stimulationszelle und verfahren zur in vitro stimulation von zellen oder geweben |
| CN114075508A (zh) * | 2020-08-14 | 2022-02-22 | 上海必修福企业管理有限公司 | 电场发生装置及其在影响细胞的分裂周期中的用途和方法 |
| CN115867639A (zh) * | 2020-08-14 | 2023-03-28 | 上海必修福企业管理有限公司 | 影响生物体生长的装置及其用途及影响生物体生长的方法 |
-
1987
- 1987-10-22 DE DE19873735702 patent/DE3735702A1/de active Granted
Non-Patent Citations (1)
| Title |
|---|
| Umschau 1966, H. 22, S. 746 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0791651A1 (de) * | 1996-01-31 | 1997-08-27 | IPR-Institute for Pharmaceutical Research Riehen AG | Method zur Behandelung von biologischem Material |
| WO2000049173A3 (de) * | 1999-02-15 | 2002-01-31 | Fraunhofer Ges Forschung | Verfahren und probenträgersystem zur trennung und anreicherung von stoffen in situ |
| US6699698B1 (en) | 1999-02-15 | 2004-03-02 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Method and sample mount system for the in situ separation and enrichment of substances |
| WO2001046692A3 (de) * | 1999-12-20 | 2002-02-14 | Forschungszentrum Juelich Gmbh | Messverfahren unter einsatz mindestens einer biologischen rezeptorzelle sowie eine zur durchführung des messverfahrens geeignete vorrichtung |
| WO2007004073A3 (en) * | 2005-04-19 | 2008-03-27 | Consiglio Nazionale Ricerche | Apparatus for culturing eucaryotic and/or procaryotic cells |
| EP2126069A4 (en) * | 2007-02-16 | 2010-05-26 | Iogenyx Pty Ltd | METHODS FOR IMPROVING CULTURE OF AQUATIC ORGANISMS |
| WO2013117193A1 (de) | 2012-02-09 | 2013-08-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V. | Stimulationszelle und verfahren zur in vitro stimulation von zellen oder geweben |
| DE102012101078A1 (de) | 2012-02-09 | 2013-10-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Stimulationszelle und Verfahren zur in vitro Stimulation von Zellen oder Geweben |
| CN114075508A (zh) * | 2020-08-14 | 2022-02-22 | 上海必修福企业管理有限公司 | 电场发生装置及其在影响细胞的分裂周期中的用途和方法 |
| CN115867639A (zh) * | 2020-08-14 | 2023-03-28 | 上海必修福企业管理有限公司 | 影响生物体生长的装置及其用途及影响生物体生长的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3735702C2 (enrdf_load_stackoverflow) | 1989-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69701190T2 (de) | Vorrichtung mit elektrodenreihen zur durchführung von chemischen, physikalischen oder physikalisch-chemischen reaktionen | |
| DE3323415C2 (de) | Verwendung eines Verfahrens und einer Vorrichtung zur Bestimmung von Zellinhaltstoffe sezernierenden Zellen | |
| DE69733888T2 (de) | Inkubation von biofilmen | |
| DE69101529T2 (de) | Liposom zum Einschliessen von Genen, liposomale Zubereitung und Verfahren zur Herstellung der Zubereitung. | |
| DE69123726T2 (de) | Manipulation von festen, semi-festen oder flüssigen materialien | |
| DE69012561T2 (de) | Verfahren und Vorrichtung zum Elektroaktivieren von Fluiden. | |
| EP2399985B1 (de) | Verfahren und Vorrichtung zur gleichmässigen Behandlung von adhärenten Zellen | |
| DE10202094B4 (de) | Verfahren und Vorrichtung zur Elektroporation biologischer Zellen | |
| DE3735702A1 (de) | Verfahren und vorrichtung zur beeinflussung von wachstum, teilung und differenzierung von zellen | |
| DE3325843C2 (enrdf_load_stackoverflow) | ||
| EP1402055A1 (de) | Verfahren zum erzeugen einer schicht funktioneller moleküle | |
| DE3784983T2 (de) | Elektrophorese, welche homogene oder inhomogene elektrische Felder mit bestimmtem Umkreis benutzt. | |
| CH640058A5 (de) | Verfahren zum messen und aufzeichnen der variation der gesamtkapazitanz und -leitfaehigkeit einer membrane, einrichtung zu dessen durchfuehrung und anwendung des verfahrens. | |
| DE2312662A1 (de) | Elektrooptische einrichtung | |
| DE3506266A1 (de) | Verfahren und vorrichtung zum kontinuierlichen lenken eines millimeterwellenlaengestrahlungsbuendels | |
| DE10006491A1 (de) | Verfahren und Probenträgersystem zur Trennung und Anreicherung von Stoffen in situ | |
| DE3321226C2 (de) | Verfahren zur Fusion von Zellen | |
| DE3786709T2 (de) | Optische fluessigkristallvorrichtungen, welche hochfrequenz-anregungen ermoeglichen. | |
| EP2607475B1 (de) | Monitoringzelle und Verfahren zur Analyse eines Zell- und Gewebewachstums | |
| EP0320709A1 (de) | Verfahren und Vorrichtung zur Stofftrennung mittels Elektrophorese | |
| Horwitz | Electrophoretic migration due to postsynaptic potential gradients: Theory and application to autonomic ganglion neurons and to dendritic spines | |
| DE102006058730A1 (de) | Zellkulturträger | |
| DE19983998B4 (de) | Vorrichtung zur elektrooptischen Zellanalyse in einer Suspension und Verfahren zur Durchführung der Analyse | |
| DE3327690C2 (de) | Verfahren zur Fusion von Zellen | |
| DE3325860A1 (de) | Verfahren und vorrichtung zur unterscheidung von in einem medium befindlichen teilchen oder partikeln |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |