DE369318C - Process for the preparation of sulfur oils and ointments - Google Patents

Process for the preparation of sulfur oils and ointments

Info

Publication number
DE369318C
DE369318C DEF48939D DEF0048939D DE369318C DE 369318 C DE369318 C DE 369318C DE F48939 D DEF48939 D DE F48939D DE F0048939 D DEF0048939 D DE F0048939D DE 369318 C DE369318 C DE 369318C
Authority
DE
Germany
Prior art keywords
sulfur
ointments
preparation
oils
sulfur oils
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEF48939D
Other languages
German (de)
Inventor
Dr Hermann Weyland
Dr Kurt Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Farbenfabriken Vorm Friedr Bayer and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farbenfabriken Vorm Friedr Bayer and Co filed Critical Farbenfabriken Vorm Friedr Bayer and Co
Priority to DEF48939D priority Critical patent/DE369318C/en
Application granted granted Critical
Publication of DE369318C publication Critical patent/DE369318C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Description

Verfahren zur Darstellung von Schwefelölen und -salben. Die Verwendung des freien Schwefels in der Dermotherapiebeschränkte sich bisher im wesentlichen auf Arzneiformen, z. B. Salben, die den Schwefel in mehr oder minder fein verteiltem Zustande enthalten., da es kein für diese Anwendungsweise geeignetes Lösungsmittel für den Schwefel gibt.Process for the preparation of sulfur oils and ointments. The usage of free sulfur in dermatotherapy has so far been essentially limited on dosage forms, e.g. B. Ointments, which the sulfur in more or less finely divided State included, as there is no solvent suitable for this type of application for the sulfur there.

Man kennt zwar ein durch Erhitzen von Leinöl mit Schwefel auf hohe Temperatur erhältliches, sogenanntes ;geschwefeltes Leinöl, doch. stellt diese dunkle zähflüssige Masse eine chemisch undefinierbare Verbindung von Schwefel mit Leinöl dar. Sie besitzt überdies einen äußerst unangenehmen Geruch.One knows one by heating linseed oil with sulfur to high So-called; sulphurized linseed oil, available at temperature, but. represents this dark viscous mass a chemically indefinable compound of sulfur and linseed oil It also has an extremely unpleasant odor.

Es wurde nun gefunden, daß die nach dem Verfahren des Patentes 365z69 erhältlichen Öle, die sich für sich als reizlose prompt wirkende Mittel gegen Skabies erwiesen haben, ausgezeichnete Lösungsmittel für Schwefel darstellen. Es gelingt z. B. mit Leichtigkeit, durch gelindes Erwärmen auf 6o bis. 70° des zwischen 16o und 23o° (to mm Druck) siedenden, aus Toluol erhaltenen Öles über 2o Prozent Schwefel in Lösung zu bringen. Beim Erkalten fällt er zum Teil wieder aus. Je nach der Viskosität des Öles lösen sich bei 2o° etwa 3 bis 6 Prozent Schwefel. Diese Lösungen zeigen eine den verwendeten Ölen gleiche goldgelbe Farbe, sind geruchlos und eignen. sich wegen ihrer Reizlosigkeit und ausgezeichneten Resorption des gelösten Schwefels zur Behandlung von Hautkrankheiten:" bei denen; die Verwendung von Schwefel angezeigt erscheint. Der gelöste Schwefel läßt sich daraus, z. B. durch Behandlung mit Äther, fast quantitativ wieder abscheiden. In diesen Schwefelölen können gegebenenfalls auch andere bei der Behandlung derartiger Krankheiten gebräuchliche Arzneimittel, z. B. Salizylsäure, Resorzin u. a., aufgelöst werden.It has now been found that the process of patent 365z69 available oils, which are non-irritating, prompt agents against scabies have proven to be excellent solvents for sulfur. It succeeds z. B. with ease, by gentle heating to 6o to. 70 ° of between 16o and 23o ° (to mm pressure) boiling oil obtained from toluene over 20 percent sulfur to bring into solution. When it cools down, it partially fails again. Depending on the viscosity of the oil dissolves about 3 to 6 percent sulfur at 20 °. These solutions show a golden yellow color, the same as the oils used, are odorless and suitable. themselves because of its lack of irritation and excellent absorption of the dissolved sulfur for the treatment of skin diseases: "in those; the use of sulfur indicated appears. The dissolved sulfur can be extracted from it, e.g. B. by treatment with ether, to be deposited again almost quantitatively. In these sulfur oils can optionally also other medicines used in the treatment of such diseases, z. B. salicylic acid, resorcinol and others.

Man kann auf diese Weise auch Salben mit hohem Schwefelgehalt darstellen, wenn man zu den warmhergestellten hochprozentigen Schwefelölen die bei der Salbenbereitung üblichen Mittel, wie z. B. Fette, wie Wachs oder Wollfett, Paraffin oderLanolin o.dgl., zufügt und: bis zum Erkalten rührt. Der Schwefel fällt hierbei in einer so feinen Verteilung aus, wie er 'bei der bisherigen Gewinnung von Salben durch Verreibung von Fetten :mit Schwefel nicht gewonnen werden konnte.In this way you can also make ointments with a high sulfur content, if you go to the warm, high-percentage sulfur oils that are used in the preparation of ointments usual means, such as B. fats such as wax or wool fat, paraffin or lanolin or the like., add and: stir until cool. The sulfur falls in one as finely distributed as he has done in the previous extraction of ointments Trituration of fats: could not be obtained with sulfur.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von. Schwefelölen und -salben, darin bestehend, daß man Schwefel in,den nach dem Verfahren des Patentes 365169 erhältlichen Ölen mit oder ohne Zusatz von Fetten und ähnlichen Produkten auflöst bzw. damit vermischt.PATENT CLAIM: Method for the representation of. Sulfur oils and ointments, consisting in the fact that sulfur is obtained in the process of patent 365169 dissolves available oils with or without the addition of fats and similar products or mixed with it.
DEF48939D 1921-03-30 1921-03-30 Process for the preparation of sulfur oils and ointments Expired DE369318C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEF48939D DE369318C (en) 1921-03-30 1921-03-30 Process for the preparation of sulfur oils and ointments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF48939D DE369318C (en) 1921-03-30 1921-03-30 Process for the preparation of sulfur oils and ointments

Publications (1)

Publication Number Publication Date
DE369318C true DE369318C (en) 1923-02-17

Family

ID=7102588

Family Applications (1)

Application Number Title Priority Date Filing Date
DEF48939D Expired DE369318C (en) 1921-03-30 1921-03-30 Process for the preparation of sulfur oils and ointments

Country Status (1)

Country Link
DE (1) DE369318C (en)

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