DE3687397D1 - 2-fluorarabinofuranosylpurinnukleoside. - Google Patents

2-fluorarabinofuranosylpurinnukleoside.

Info

Publication number
DE3687397D1
DE3687397D1 DE8686114412T DE3687397T DE3687397D1 DE 3687397 D1 DE3687397 D1 DE 3687397D1 DE 8686114412 T DE8686114412 T DE 8686114412T DE 3687397 T DE3687397 T DE 3687397T DE 3687397 D1 DE3687397 D1 DE 3687397D1
Authority
DE
Germany
Prior art keywords
fluorarabinofuranosylpurine
nucleosides
fluorarabinofuranosylpurine nucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686114412T
Other languages
English (en)
Other versions
DE122006000056I1 (de
DE122006000056I2 (de
DE3687397T2 (de
Inventor
Kyoichi A Watanabe
Chung K Chu
Jack J Fox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Sloan Kettering Institute for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Institute for Cancer Research filed Critical Sloan Kettering Institute for Cancer Research
Publication of DE3687397D1 publication Critical patent/DE3687397D1/de
Application granted granted Critical
Publication of DE3687397T2 publication Critical patent/DE3687397T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE8686114412T 1985-10-18 1986-10-17 2-fluorarabinofuranosylpurinnukleoside. Expired - Fee Related DE3687397T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/789,072 US4751221A (en) 1985-10-18 1985-10-18 2-fluoro-arabinofuranosyl purine nucleosides

Publications (2)

Publication Number Publication Date
DE3687397D1 true DE3687397D1 (de) 1993-02-11
DE3687397T2 DE3687397T2 (de) 1993-07-01

Family

ID=25146507

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8686114412T Expired - Fee Related DE3687397T2 (de) 1985-10-18 1986-10-17 2-fluorarabinofuranosylpurinnukleoside.
DE19863687397 Active DE122006000056I2 (de) 1985-10-18 1986-10-17 2-Fluorarabinofuranosylpurinnukleoside

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19863687397 Active DE122006000056I2 (de) 1985-10-18 1986-10-17 2-Fluorarabinofuranosylpurinnukleoside

Country Status (5)

Country Link
US (2) US4751221A (de)
EP (1) EP0219829B1 (de)
JP (1) JPH0723395B2 (de)
CA (1) CA1271192A (de)
DE (2) DE3687397T2 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
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US5310732A (en) * 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
IL84842A0 (en) * 1986-12-24 1988-06-30 Lilly Co Eli Immunoglobulin conjugates
GB8708050D0 (en) * 1987-04-03 1987-05-07 Wellcome Found Therapeutic nucleosides
US5175274A (en) * 1987-04-03 1992-12-29 Burroughs Wellcome Co. Therapeutic nucleosides
US5495010A (en) * 1987-04-17 1996-02-27 The United States Of America As Represented By The Department Of Health And Human Services Acid stable purine dideoxynucleosides
US5459256A (en) * 1987-04-17 1995-10-17 The Government Of The United States Of America As Represented By The Department Of Health And Human Services Lipophilic, aminohydrolase-activated prodrugs
CA1339964C (en) * 1988-03-16 1998-07-21 Dennis A. Carson Substituted adenine derivatives useful as therapeutic agents
GB8815241D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Antiviral combinations & compounds therefor
GB8816345D0 (en) * 1988-07-08 1988-08-10 Hoffmann La Roche Purine derivatives
US5026688A (en) * 1988-10-31 1991-06-25 Administrators Of The Tulane Educational Fund Novel AZT analogs
US5034518A (en) * 1989-05-23 1991-07-23 Southern Research Institute 2-fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine nucleosides
US5384310A (en) * 1989-05-23 1995-01-24 Southern Research Institute 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
GB8920534D0 (en) * 1989-09-11 1989-10-25 Wellcome Found Antiviral compounds
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
US5681941A (en) * 1990-01-11 1997-10-28 Isis Pharmaceuticals, Inc. Substituted purines and oligonucleotide cross-linking
JPH05505815A (ja) * 1990-04-04 1993-08-26 ニユコメド・イメージング・アクシエセルカペト ヌクレオシド誘導体
US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
US5420115A (en) * 1990-09-10 1995-05-30 Burroughs Wellcome Co. Method for the treatment of protoza infections with 21 -deoxy-21 -fluoropurine nucleosides
WO1992011276A1 (en) * 1990-12-18 1992-07-09 Sloan-Kettering Institute For Cancer Research Novel synthesis of 2'-'up' fluorinated 2''-deoxy-arabinofuranosylpurines
US5672697A (en) * 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
EP0642347A4 (de) * 1992-05-19 1997-06-18 Scripps Research Inst Verwendung von 2-halo-adeninderivaten als therapeutische wirkstoffe gegen chronisch-myeloische leukämie.
KR940005654A (ko) * 1992-06-22 1994-03-22 리로이 휘테커 입체선택적인 음이온 글리코실화 방법
US5401838A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5594124A (en) * 1992-06-22 1997-01-14 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
US5821357A (en) * 1992-06-22 1998-10-13 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5426183A (en) * 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5602246A (en) * 1992-11-25 1997-02-11 Schering Aktiengesellschaft Process for the preparation of fludarabine or fludarabine phosphate from guanosine
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
US6491905B1 (en) * 1993-09-14 2002-12-10 The Uab Research Foundation Recombinant bacterial cells for delivery of PNP to tumor cells
US5525606A (en) 1994-08-01 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
US5641757A (en) * 1994-12-21 1997-06-24 Ortho Pharmaceutical Corporation Stable 2-chloro-2'-deoxyadenosine formulations
US6232463B1 (en) 1997-10-09 2001-05-15 Isis Pharmaceuticals, Inc. Substituted purines and oligonucleotide cross-linking
JPH11217396A (ja) * 1998-01-30 1999-08-10 Ajinomoto Co Inc ヌクレオシド誘導体の製造方法
US6060458A (en) * 1998-02-13 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxyribonucleotides comprising O6 -benzylguanine and their use
DK1261350T3 (da) * 2000-02-18 2006-11-13 Southern Res Inst Fremgangsmåder til syntetisering af 2-chlor-9-(2-deoxy-2-fluor-beta-d-arabinofuranosyl)-9H-purin-6-amin
AU2005234681B2 (en) * 2000-02-18 2008-11-20 Southern Research Institute Methods for Synthesizing 2-Chloro-9-(2-Deoxy-2-Fluoro-Beta-D-Arabinofuranosyl)-9H-Purin-6-Amine
US7528247B2 (en) * 2001-08-02 2009-05-05 Genzyme Corporation Process for preparing purine nucleosides
US6680382B2 (en) 2001-08-02 2004-01-20 Ilex Products, Inc. Process for preparing purine nucleosides
US7022680B2 (en) * 2002-05-30 2006-04-04 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases
CA2500360A1 (en) * 2002-09-27 2004-04-08 Bioenvision, Inc. Methods and compositions for the treatment of autoimmune disorders using clofarabine
AU2003276987B2 (en) * 2002-09-27 2009-07-30 Bioenvision, Inc. Methods and compositions for the treatment of lupus using clofarabine
EP1460082A1 (de) 2003-03-19 2004-09-22 Heidelberg Pharma Holding GmbH Phospholipidester von clofarabin-derivate
US7273600B2 (en) * 2003-04-25 2007-09-25 University Of Southern California [18F]-furanosylpurine derivatives and uses thereof
JP4658807B2 (ja) * 2003-10-24 2011-03-23 ヤマサ醤油株式会社 α−１−リン酸化２−デオキシ−２−フルオロアラビノシド及び２’−デオキシ−２’−フルオロ−β−Ｄ−アラビノヌクレオシドの製造法
WO2006015346A1 (en) * 2004-07-30 2006-02-09 Pharmaessentia Corp. STEREOSELECTIVE SYNTHESIS OF β-NUCLEOSIDES
US7485716B2 (en) * 2005-05-02 2009-02-03 Pharmaessentia Corp. Stereoselective synthesis of β-nucleosides
JP2009506118A (ja) * 2005-08-29 2009-02-12 ケマジス・リミテッド ゲムシタビンおよび関連中間体の製造方法
CA2641719A1 (en) * 2006-02-07 2007-08-16 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
EP2024323B1 (de) * 2006-06-06 2013-03-27 Gicare Pharma Inc. Salze von trimebutin und n-desmethyltrimebutin
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
WO2009042064A2 (en) 2007-09-21 2009-04-02 Nektar Therapeutics Al, Corporation Oligomer-nucleoside phosphate conjugates
AU2008323923A1 (en) * 2007-11-06 2009-05-14 Pharmaessentia Corporation Novel synthesis of beta-nucleosides
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
ES2341215B1 (es) * 2008-12-15 2011-04-26 Consejo Superior De Investigaciones Cientificas (Csic) (51%) Nucleosidos modificados para el tratamiento de infecciones por leishmania.
ES2341603B1 (es) * 2008-12-15 2011-04-28 Consejo Superior De Investigaciones Cientificas (Csic) (51%) Derivados de nucleosidos para el tratamiento de infecciones por leishmania.
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
SG194404A1 (en) 2008-12-23 2013-11-29 Gilead Pharmasset Llc Synthesis of purine nucleosides
US8716262B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Nucleoside phosphoramidates
EP2410987B1 (de) 2009-03-23 2018-05-16 Ambit Biosciences Corporation Behandlungsverfahren mit kombinationstherapien
CA2761880A1 (en) * 2009-05-12 2010-11-18 John A. Secrist, Iii 2'-fluoro arabino nucleosides and use thereof
US9790252B2 (en) 2009-07-01 2017-10-17 Cornell University 2-fluorinated riboses and arabinoses and methods of use and synthesis
US9011817B2 (en) * 2009-09-03 2015-04-21 The Board Of Trustees Of The Leland Stanford Junior University Compounds and methods of making compounds
CN104017020B (zh) 2010-03-31 2017-04-12 吉利德制药有限责任公司 核苷氨基磷酸酯
CN102311472B (zh) 2010-07-09 2014-09-03 神隆(昆山)生化科技有限公司 2-氯-9-(2’-脱氧-2’-氟-β-D-阿拉伯呋喃糖基)-腺嘌呤的制备
CN104193790A (zh) * 2014-09-25 2014-12-10 王庚禹 一种甲酰腺嘌呤化合物
US10851125B2 (en) 2017-08-01 2020-12-01 Gilead Sciences, Inc. Crystalline forms of ethyl ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl(-L-alaninate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3928319A (en) * 1971-06-16 1975-12-23 Syntex Inc 4 -Fluoro nucleosides, novel intermediates and methods of preparing same
DE2628202A1 (de) * 1976-06-23 1977-12-29 Max Planck Gesellschaft Verfahren zur herstellung von 2'-substituierten-d-ribofuranosylpurinderivaten
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides

Also Published As

Publication number Publication date
JPH0723395B2 (ja) 1995-03-15
EP0219829A3 (en) 1988-05-04
US4751221A (en) 1988-06-14
EP0219829A2 (de) 1987-04-29
JPS62161797A (ja) 1987-07-17
EP0219829B1 (de) 1992-12-30
US4918179A (en) 1990-04-17
DE122006000056I1 (de) 2007-01-18
CA1271192A (en) 1990-07-03
DE122006000056I2 (de) 2007-05-31
DE3687397T2 (de) 1993-07-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: CLOFARABIN; REGISTRATION NO/DATE: EU/1/06/334/001 - EU/1/06/334/004; 20060529

Spc suppl protection certif: 12 2006 000 056

Filing date: 20061016

V484 Delivery of the decision of grant

Free format text: PRODUCT NAME: CLOFARABIN; REGISTRATION NO/DATE: EU/1/06/334/001 - EU/1/06/334/004; 20060529

Spc suppl protection certif: 12 2006 000 056

Filing date: 20061016

V457 Spc granted

Free format text: PRODUCT NAME: CLOFARABIN; REGISTRATION NO/DATE: EU/1/06/334/001 - EU/1/06/334/004; 20060529

Spc suppl protection certif: 12 2006 000 056

Filing date: 20061016

R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Free format text: PRODUCT NAME: CLOFARABIN ODER EIN PHARMAZEUTISCH VERTRAEGLICHES SAEUREADDITIONSSALZ DAVON; REGISTRATION NO/DATE: EU/1/06/334/001-004 20060529

Spc suppl protection certif: 122006000056

Filing date: 20061016

Expiry date: 20061018

Extension date: 20111017

Effective date: 20110503