DE3686876D1 - 4-MORPHOLINYL 1H-INDOL DERIVATIVES, THEIR SALTS, METHODS AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION, USE AS MEDICINAL PRODUCTS, COMPOSITIONS CONTAINING THE SAME. - Google Patents

4-MORPHOLINYL 1H-INDOL DERIVATIVES, THEIR SALTS, METHODS AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION, USE AS MEDICINAL PRODUCTS, COMPOSITIONS CONTAINING THE SAME.

Info

Publication number
DE3686876D1
DE3686876D1 DE8686402764T DE3686876T DE3686876D1 DE 3686876 D1 DE3686876 D1 DE 3686876D1 DE 8686402764 T DE8686402764 T DE 8686402764T DE 3686876 T DE3686876 T DE 3686876T DE 3686876 D1 DE3686876 D1 DE 3686876D1
Authority
DE
Germany
Prior art keywords
carbon atoms
alkyl
morpholinyl
group
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686402764T
Other languages
German (de)
Other versions
DE3686876T2 (en
Inventor
Jean-Claude Gasc
Lucien Nedelec
Claude Rettien
Nanopoulos Dinah Weissmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of DE3686876D1 publication Critical patent/DE3686876D1/en
Application granted granted Critical
Publication of DE3686876T2 publication Critical patent/DE3686876T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Abstract

Novel racemic mixtures and optical isomers of 4-morpholinyl-1H-indoles of the formula: <IMAGE> I wherein R and R1 are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and R2 is selected from the group consisting of hydroxymethyl, alkylthiomethyl of 1 to 3 alkyl carbons, cyanomethyl and carboxy optionally esterified with an aliphatic alcohol of 1 to 5 carbon atoms or optionally amidified with an amine of the formula <IMAGE> R3 is alkyl of 1 to 4 carbon atoms and R4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having the ability to activate neurons and to protect the same against ischemic or anoxic aggressions.
DE8686402764T 1985-12-13 1986-12-11 4-MORPHOLINYL 1H-INDOL DERIVATIVES, THEIR SALTS, METHODS AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION, USE AS MEDICINAL PRODUCTS, COMPOSITIONS CONTAINING THE SAME. Expired - Fee Related DE3686876T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8518482A FR2591595B1 (en) 1985-12-13 1985-12-13 NOVEL 4-MORPHOLINYL 1H-INDOLE DERIVATIVES, SALTS THEREOF, PROCESS FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS, COMPOSITIONS CONTAINING THEM, AND INTERMEDIATES

Publications (2)

Publication Number Publication Date
DE3686876D1 true DE3686876D1 (en) 1992-11-05
DE3686876T2 DE3686876T2 (en) 1993-05-06

Family

ID=9325757

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686402764T Expired - Fee Related DE3686876T2 (en) 1985-12-13 1986-12-11 4-MORPHOLINYL 1H-INDOL DERIVATIVES, THEIR SALTS, METHODS AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION, USE AS MEDICINAL PRODUCTS, COMPOSITIONS CONTAINING THE SAME.

Country Status (11)

Country Link
US (2) US4699907A (en)
EP (1) EP0230179B1 (en)
JP (1) JPS62148485A (en)
AT (1) ATE81127T1 (en)
CA (1) CA1266471A (en)
DE (1) DE3686876T2 (en)
ES (1) ES2043605T3 (en)
FR (1) FR2591595B1 (en)
GR (1) GR3006137T3 (en)
HU (1) HU199458B (en)
PT (1) PT83920B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264442A (en) * 1990-08-13 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
DE69114210T2 (en) * 1990-08-13 1996-05-02 Hoechst Roussel Pharma Carbamoyl-1- (pyridinylalkyl) -1H-indoles, indolines and related compounds.
FR2792313A1 (en) * 1999-04-13 2000-10-20 Synthelabo 2-AMINOETHYL-INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
AU2001256733A1 (en) 2000-05-16 2001-11-26 Takeda Chemical Industries Ltd. Melanin-concentrating hormone antagonist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2501208A1 (en) * 1981-09-17 1982-09-10 Roussel Uclaf 4-Morpholinyl-indole and di:hydro-indole derivs. - useful as dopaminergic agonists
FR2512817A1 (en) * 1981-09-17 1983-03-18 Roussel Uclaf NOVEL AMINOMETHYL 1H-INDOLE-4-METHANOL DERIVATIVES AND THEIR SALTS, PROCESS FOR PREPARING THEM, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS COMPRISING THEM AND THEIR PREPARATION INTERMEDIATES

Also Published As

Publication number Publication date
HUT45996A (en) 1988-09-28
GR3006137T3 (en) 1993-06-21
ATE81127T1 (en) 1992-10-15
CA1266471A (en) 1990-03-06
EP0230179A2 (en) 1987-07-29
US4736042A (en) 1988-04-05
HU199458B (en) 1990-02-28
FR2591595B1 (en) 1988-09-09
US4699907A (en) 1987-10-13
DE3686876T2 (en) 1993-05-06
FR2591595A1 (en) 1987-06-19
EP0230179A3 (en) 1988-05-18
ES2043605T3 (en) 1994-01-01
PT83920A (en) 1987-01-01
JPS62148485A (en) 1987-07-02
EP0230179B1 (en) 1992-09-30
PT83920B (en) 1989-06-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee