AT383599B - Process for the preparation of novel racemic and optically active E-homo-eburnane derivatives and of acid addition salts thereof - Google Patents

Process for the preparation of novel racemic and optically active E-homo-eburnane derivatives and of acid addition salts thereof

Info

Publication number
AT383599B
AT383599B AT238983A AT238983A AT383599B AT 383599 B AT383599 B AT 383599B AT 238983 A AT238983 A AT 238983A AT 238983 A AT238983 A AT 238983A AT 383599 B AT383599 B AT 383599B
Authority
AT
Austria
Prior art keywords
acid addition
optically active
addition salts
homo
preparation
Prior art date
Application number
AT238983A
Other languages
German (de)
Other versions
ATA238983A (en
Inventor
Csaba Dr Szantay
Lajos Dr Szabo
Gyoergy Dr Kalaus
Janos Dipl Ing Sapi
Eva Dr Palosi
Egon Dr Karpati
Laszlo Dr Szporny
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU822130A external-priority patent/HU190399B/en
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Priority to AT238983A priority Critical patent/AT383599B/en
Publication of ATA238983A publication Critical patent/ATA238983A/en
Application granted granted Critical
Publication of AT383599B publication Critical patent/AT383599B/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to a process for the preparation of novel racemic and optically active E-homo-eburnane derivatives and the physiologically tolerated acid addition salts thereof. The novel compounds correspond to the general formula I in which R<1> and R<2> are identical or different and are alkyl groups having 1 to 6 carbon atoms. The compounds are obtained by cyclization of racemic or optically active compounds of the general formula II or acid addition salts thereof, in which A is hydrogen or the groups of the general formulae -CH2-CH(CO2R<1>)2 or -CH2-C(CO2R<1>)2- -CH2-CH(CO2R<1>)2 and R<3> is identical to R<1> or, if A is hydrogen, R<3> can likewise be hydrogen. The compounds of the general formula (I) show antidepressant and antihypoxic properties. <IMAGE>
AT238983A 1982-06-30 1983-06-29 Process for the preparation of novel racemic and optically active E-homo-eburnane derivatives and of acid addition salts thereof AT383599B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT238983A AT383599B (en) 1982-06-30 1983-06-29 Process for the preparation of novel racemic and optically active E-homo-eburnane derivatives and of acid addition salts thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU822130A HU190399B (en) 1982-06-30 1982-06-30 Process for the production of e-homo-eburnane-derivatives
AT238983A AT383599B (en) 1982-06-30 1983-06-29 Process for the preparation of novel racemic and optically active E-homo-eburnane derivatives and of acid addition salts thereof

Publications (2)

Publication Number Publication Date
ATA238983A ATA238983A (en) 1986-12-15
AT383599B true AT383599B (en) 1987-07-27

Family

ID=25598344

Family Applications (1)

Application Number Title Priority Date Filing Date
AT238983A AT383599B (en) 1982-06-30 1983-06-29 Process for the preparation of novel racemic and optically active E-homo-eburnane derivatives and of acid addition salts thereof

Country Status (1)

Country Link
AT (1) AT383599B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3026584A1 (en) * 1979-08-13 1981-05-07 Richter Gedeon Vegyészeti Gyár R.T., Budapest 10-HALOGEN-14-OXON-15-HYDROXY-E-HOMOEBURN OTHER DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THEM

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3026584A1 (en) * 1979-08-13 1981-05-07 Richter Gedeon Vegyészeti Gyár R.T., Budapest 10-HALOGEN-14-OXON-15-HYDROXY-E-HOMOEBURN OTHER DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THEM

Also Published As

Publication number Publication date
ATA238983A (en) 1986-12-15

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