DE3684561D1 - Vorrichtung und verfahren zur kultivierung von zellen zum abfuehren von rueckstand und zur konzentration des produktes. - Google Patents

Vorrichtung und verfahren zur kultivierung von zellen zum abfuehren von rueckstand und zur konzentration des produktes.

Info

Publication number
DE3684561D1
DE3684561D1 DE8686115226T DE3684561T DE3684561D1 DE 3684561 D1 DE3684561 D1 DE 3684561D1 DE 8686115226 T DE8686115226 T DE 8686115226T DE 3684561 T DE3684561 T DE 3684561T DE 3684561 D1 DE3684561 D1 DE 3684561D1
Authority
DE
Germany
Prior art keywords
medium
reservoir
waste
membrane
concentrating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686115226T
Other languages
German (de)
English (en)
Inventor
William H Harm
Mark D Hirschel
Michael L Gruenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Endotronics Inc
Original Assignee
Endotronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endotronics Inc filed Critical Endotronics Inc
Application granted granted Critical
Publication of DE3684561D1 publication Critical patent/DE3684561D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE8686115226T 1985-11-04 1986-11-03 Vorrichtung und verfahren zur kultivierung von zellen zum abfuehren von rueckstand und zur konzentration des produktes. Expired - Fee Related DE3684561D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/794,627 US4722902A (en) 1985-11-04 1985-11-04 Apparatus and method for culturing cells, removing waste and concentrating product

Publications (1)

Publication Number Publication Date
DE3684561D1 true DE3684561D1 (de) 1992-04-30

Family

ID=25163183

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686115226T Expired - Fee Related DE3684561D1 (de) 1985-11-04 1986-11-03 Vorrichtung und verfahren zur kultivierung von zellen zum abfuehren von rueckstand und zur konzentration des produktes.

Country Status (7)

Country Link
US (1) US4722902A (cg-RX-API-DMAC7.html)
EP (1) EP0224734B1 (cg-RX-API-DMAC7.html)
JP (1) JPS62171669A (cg-RX-API-DMAC7.html)
AT (1) ATE74158T1 (cg-RX-API-DMAC7.html)
AU (1) AU6463286A (cg-RX-API-DMAC7.html)
CA (1) CA1270455A (cg-RX-API-DMAC7.html)
DE (1) DE3684561D1 (cg-RX-API-DMAC7.html)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4851334A (en) * 1984-01-03 1989-07-25 The New York Blood Center, Inc. Monoclonal antibodies specific to in vivo fragments derived from human fibrinogen, human fibrin I or human fibrin II
US5286646A (en) * 1985-11-25 1994-02-15 Boehringer Mannheim Gmbh Method for mammalian cell culture
US6022742A (en) * 1986-11-26 2000-02-08 Kopf; Henry B. Culture device and method
DE3641826A1 (de) * 1986-12-06 1988-06-16 Bayer Ag Verfahren zur kultivierung von saeugerzellen in einer suspensionskultur, vorrichtung zur durchfuehrung des verfahrens und verwendung bei der herstellung von proteinen
US4921792A (en) * 1987-11-27 1990-05-01 Miles Inc. Continuous cell dispersion, cultivation and substance recovery process
JPH0646937B2 (ja) * 1988-10-17 1994-06-22 雪印乳業株式会社 培養液の濃縮装置
US5002890A (en) * 1988-11-29 1991-03-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Spiral vane bioreactor
JP2777385B2 (ja) * 1988-11-30 1998-07-16 株式会社日立製作所 生物細胞の培養方法，培養システム及び培養装置
US5187095A (en) * 1988-12-19 1993-02-16 Baxter International Inc. Apparatus for culturing animal cells
US5102790A (en) * 1988-12-19 1992-04-07 Baxter International Inc. Method for culturing animal cells
FR2640638B1 (fr) * 1988-12-20 1991-02-15 Commissariat Energie Atomique Bioreacteur et dispositif pour la culture de cellules animales
AU6355790A (en) * 1989-08-04 1991-03-11 Peter Grandics An integrated cell culture-protein purification system for the automated production and purification of cell culture products
US5346826A (en) * 1989-10-18 1994-09-13 Andrews Franklin T Process for conducting biochemical reactions
JPH03175949A (ja) * 1989-12-05 1991-07-31 Hokkaido Prefecture 膜法によるスティックウォーターからの天然調味料の製造方法
US5268298A (en) * 1991-04-26 1993-12-07 Life Technologies, Inc. System for delivering oxygen to a cell culture medium
DE4116727C2 (de) * 1991-05-17 1995-09-07 Uwe Dr Marx Verfahren und Vorrichtung zur gleichzeitigen Kultivierung unterschiedlicher Säugerzellen
US5330915A (en) * 1991-10-18 1994-07-19 Endotronics, Inc. Pressure control system for a bioreactor
US5353745A (en) * 1992-09-29 1994-10-11 Fahs Ii Richard W Aquaculture system and methods for using the same
US5424209A (en) * 1993-03-19 1995-06-13 Kearney; George P. Automated cell culture and testing system
US5622819A (en) * 1995-03-28 1997-04-22 Kinetic Biosystems, Inc. Centrifugal fermentation process
US6133019A (en) * 1995-03-28 2000-10-17 Kinetic Biosystems, Inc. Centrifugal fermentation process
US20050266548A1 (en) * 1995-03-28 2005-12-01 Kbi Biopharma, Inc. Biocatalyst chamber encapsulation system for bioremediation and fermentation with improved rotor
US6916652B2 (en) * 1995-03-28 2005-07-12 Kinetic Biosystems, Inc. Biocatalyst chamber encapsulation system for bioremediation and fermentation
US6660509B1 (en) 1995-03-28 2003-12-09 Kinetic Biosystems, Inc. Methods and devices for remediation and fermentation
US6214617B1 (en) 1995-03-28 2001-04-10 Kinetic Biosystems, Inc. Centrifugal fermentation process
US5728581A (en) * 1995-06-07 1998-03-17 Systemix, Inc. Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein
US20020182730A1 (en) * 1995-07-26 2002-12-05 Micheal L. Gruenberg Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
US5627070A (en) * 1995-07-26 1997-05-06 Celltherapy, Inc. Cell growing device for in vitro cell population expansion
DE19727731A1 (de) * 1997-06-30 1999-01-07 Forschungszentrum Juelich Gmbh Verfahren und Vorrichtung zum Eintrag von Reagenzien in Reaktoren
AU2001236601A1 (en) 2000-01-31 2001-08-07 Robert A. Cuneo Methods and devices for remediation and fermentation
EP1325110A4 (en) * 2000-10-02 2009-03-25 Thomas F Cannon AUTOMATED BIOCULTURE AND BIOCULTURAL EXPERIENCE SYSTEM
US20020146817A1 (en) * 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
FR2821947B1 (fr) * 2001-03-12 2003-05-16 Canon Kk Procede et dispositif de validation de parametres definissant une image
US20030134415A1 (en) * 2001-09-19 2003-07-17 Gruenberg Micheal L. Th1 cell adoptive immunotherapy
US20030134341A1 (en) * 2001-09-19 2003-07-17 Medcell Biologics, Llc. Th1 cell adoptive immunotherapy
US20030175272A1 (en) * 2002-03-07 2003-09-18 Medcell Biologics, Inc. Re-activated T-cells for adoptive immunotherapy
ES2755552T3 (es) * 2002-06-19 2020-04-22 Northwest Biotherapeutics Inc Dispositivos de filtración de flujo tangencial y métodos para el enriquecimiento de leucocitos
US7790039B2 (en) * 2003-11-24 2010-09-07 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for stem cell enrichment
EP1786894A4 (en) * 2004-09-10 2007-12-12 Unisearch Ltd DEVICE AND METHOD FOR PREVENTING CULTURE MEDIA REMOVAL
CA2678893C (en) * 2007-03-05 2015-12-29 Caridianbct, Inc. Methods to control cell movement in hollow fiber bioreactors
EP2129764B1 (en) * 2007-03-05 2018-10-10 Terumo BCT, Inc. Cell expansion system and methods of use
EP2148922B1 (en) * 2007-04-13 2020-03-04 Terumo BCT, Inc. Cell expansion system and methods of use
US8691565B2 (en) 2008-03-05 2014-04-08 Terumo Bct, Inc. Method of reseeding adherent cells grown in a hollow fiber bioreactor system
WO2010003759A2 (en) * 2008-06-17 2010-01-14 Dsm Ip Assets B.V. Cell culturing method
US8778669B2 (en) * 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
KR102027596B1 (ko) * 2010-12-06 2019-10-01 타폰 바이오시스템즈, 인코포레이티드 생물학적 산물을 위한 연속 처리 방법
EP2885393A1 (en) 2012-08-20 2015-06-24 Terumo BCT, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
US9005550B2 (en) 2012-10-29 2015-04-14 Corning Incorporated Multi-layered cell culture vessel with manifold grips
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
CN106232800B (zh) 2014-03-25 2020-07-03 泰尔茂比司特公司 介质的被动替代
WO2015164808A1 (en) 2014-04-24 2015-10-29 Terumo Bct, Inc. Measuring flow rate
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
KR20180074775A (ko) * 2015-10-26 2018-07-03 론자 리미티드 생물약제의 생산을 위한 제조 설비
WO2017193075A1 (en) * 2016-05-05 2017-11-09 Terumo Bct, Inc. Automated production and collection
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. CELL EXPANSION
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3656842A1 (en) 2017-03-31 2020-05-27 Terumo BCT, Inc. Cell expansion
CN110831684A (zh) * 2017-07-03 2020-02-21 株式会社村田制作所 浓缩装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3186917A (en) * 1962-04-18 1965-06-01 Biochemical Processes Inc Process and apparatus for dialysis fermentation
US3969190A (en) * 1971-05-17 1976-07-13 Martin Marietta Corporation Apparatus and method for microbial fermentation in a zero gravity environment
US3883393A (en) * 1972-05-18 1975-05-13 Us Health Education & Welfare Cell culture on semi-permeable tubular membranes
US3992301A (en) * 1973-11-19 1976-11-16 Raypak, Inc. Automatic flushing system for membrane separation machines such as reverse osmosis machines
DE2726313C3 (de) * 1977-06-10 1980-02-07 Battelle-Institut E.V., 6000 Frankfurt Verfahren zur in-vitro-Biosynthese von Hormonen, insbesondere von Insulin
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
GB2168617B (en) * 1984-12-12 1988-08-10 Bo Gustav Mattiasson A procedure and an apparatus for continuous separation and purification of reaction products

Also Published As

Publication number Publication date
JPS62171669A (ja) 1987-07-28
JPH0120866B2 (cg-RX-API-DMAC7.html) 1989-04-18
US4722902A (en) 1988-02-02
EP0224734B1 (en) 1992-03-25
AU6463286A (en) 1987-05-07
CA1270455A (en) 1990-06-19
ATE74158T1 (de) 1992-04-15
EP0224734A1 (en) 1987-06-10

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee