DE3677494D1 - Virus-impfstoff. - Google Patents

Virus-impfstoff.

Info

Publication number
DE3677494D1
DE3677494D1 DE8686904022T DE3677494T DE3677494D1 DE 3677494 D1 DE3677494 D1 DE 3677494D1 DE 8686904022 T DE8686904022 T DE 8686904022T DE 3677494 T DE3677494 T DE 3677494T DE 3677494 D1 DE3677494 D1 DE 3677494D1
Authority
DE
Germany
Prior art keywords
virus
animals
vaccine
wild
deletion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686904022T
Other languages
English (en)
Inventor
E Post
R Thomsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DE3677494D1 publication Critical patent/DE3677494D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16721—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
DE8686904022T 1985-07-29 1986-06-17 Virus-impfstoff. Expired - Lifetime DE3677494D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76013085A 1985-07-29 1985-07-29
PCT/US1986/001322 WO1987000862A1 (en) 1985-07-29 1986-06-17 Virus vaccine

Publications (1)

Publication Number Publication Date
DE3677494D1 true DE3677494D1 (de) 1991-03-14

Family

ID=25058182

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686904022T Expired - Lifetime DE3677494D1 (de) 1985-07-29 1986-06-17 Virus-impfstoff.

Country Status (18)

Country Link
US (1) US4810634A (de)
EP (1) EP0231209B1 (de)
JP (2) JP2559384B2 (de)
KR (1) KR950000887B1 (de)
CN (1) CN1018845B (de)
AT (1) ATE60799T1 (de)
AU (1) AU591145B2 (de)
CA (1) CA1275625C (de)
DE (1) DE3677494D1 (de)
DK (1) DK170948B1 (de)
ES (1) ES2001752A6 (de)
FI (1) FI871362A0 (de)
HK (1) HK32696A (de)
IE (1) IE59087B1 (de)
NO (1) NO301284B1 (de)
PH (1) PH25776A (de)
WO (1) WO1987000862A1 (de)
ZA (1) ZA865277B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041536A (en) * 1984-05-02 1991-08-20 The Upjohn Company Pseudorabies virus (PRV) gene
US5275934A (en) * 1985-07-29 1994-01-04 The Upjohn Company Method of detecting viral infection in vaccinated animals
EP0263207B1 (de) * 1986-10-08 1991-11-27 The Upjohn Company Virus-Vakzin
US5128128A (en) * 1985-07-29 1992-07-07 The Upjohn Company Virus vaccine
US5068192A (en) * 1986-01-27 1991-11-26 Prutech Research And Development Partnership Attenuated pseudorabies virus which includes foreign DNA encoding an amino acid sequence
US5047237A (en) * 1985-09-06 1991-09-10 Prutech Research And Development Partnership Attenuated pseudorabies virus having a deletion of at least a portion of a gene encoding an antigenic, nonessential protein, vaccine containing same and methods of identifying animals vaccinated with the vaccine
US5763269A (en) * 1985-09-06 1998-06-09 Syntro Corporation Recombinant infectious bovine rhinotrocheitis virus
EP0238618A1 (de) * 1985-10-04 1987-09-30 The Upjohn Company Pseudorabiesvirus-protein
US5352575A (en) * 1985-10-04 1994-10-04 The Upjohn Company Pseudorabies virus protein
US5593873A (en) * 1986-01-27 1997-01-14 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus
EP0256092B1 (de) * 1986-01-27 1998-04-08 Syntro Corporation Abgeschwächte herpesviren, herpesviren, die eine für aminosäuresequenzen kodierende fremd-dns enthalten, sowie impfstoffe, die diese enthalten
US6172186B1 (en) 1986-03-26 2001-01-09 Pharmacia & Upjohn Company Pseudorabies virus protein
FR2601689B1 (fr) * 1986-07-17 1992-10-16 Syntro Corp Herpes virus attenues, herpes virus qui renferment de l'adn etranger codant pour une sequence d'amino-acides, et vaccins les contenant
US5004693A (en) * 1986-07-18 1991-04-02 E. I. Du Pont De Nemours And Company Pseudorabies virus recombinants and their use in the production of proteins
US5037742A (en) * 1986-07-18 1991-08-06 E. I. Du Pont De Nemours And Company Pseudorabies virus recombinants and their use in the production of proteins
WO1988007088A1 (en) * 1987-03-19 1988-09-22 Synergen, Inc. Viral vector system for the introduction of foreign dna expression products into gallinaceous birds
US5273876A (en) * 1987-06-26 1993-12-28 Syntro Corporation Recombinant human cytomegalovirus containing foreign gene
US5783195A (en) * 1991-07-18 1998-07-21 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus S-IBR-052 and uses thereof
AU628294B2 (en) * 1987-07-27 1992-09-17 Syntro Corporation Attenuated herpes viruses, herpes viruses which include foreign dna encoding an amino acid sequence and vaccines containing same
US4992051A (en) * 1987-11-03 1991-02-12 Novagene, Inc. Infectious bovine rhinotracheitis virus mutants, methods for the production of same and methods for the use of same
US5128129A (en) * 1987-11-03 1992-07-07 Novagene Inc. Infectious bovine rhinotrachetis virus mutants, vaccines containing same, methods for the production of same and methods for the use of same
US5069901A (en) * 1988-02-03 1991-12-03 Jones Elaine V Preparation of a recombinant subunit vaccine against pseudorabies infection
JP2779447B2 (ja) * 1988-03-20 1998-07-23 財団法人阪大微生物病研究会 弱毒マレック病ウイルス・ベクターを用いる組換え遺伝子作成法、及び該ウイルスの組換え体
JP2583115B2 (ja) * 1988-09-10 1997-02-19 財団法人化学及血清療法研究所 組換えマレック病ウイルスおよびその製法
US5122447A (en) * 1989-01-23 1992-06-16 Iowa State University Research Foundation, Inc. Method of detecting pseudorabies virus specific serum antibody by use of a universal diagnostic antigen
US5240703A (en) * 1991-03-01 1993-08-31 Syntro Corporation Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof
US5874279A (en) * 1991-07-18 1999-02-23 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus
AU672583B2 (en) * 1991-07-18 1996-10-10 Prutech Research And Development Partnership Recombinant infectious bovine rhinotracheitis virus
WO1993024147A1 (en) * 1992-05-29 1993-12-09 Smithkline Beecham Corporation Lecithin adjuvanted modified live virus vaccines
TW289731B (de) * 1992-07-09 1996-11-01 Akzo Nv
EP0606452B1 (de) * 1992-07-30 2002-11-13 Akzo Nobel N.V. Impfstoff-vektoren von rekombinantem katzen-herpesvirus
JPH07502173A (ja) * 1992-10-06 1995-03-09 アクゾ・ノベル・エヌ・ベー 偽性狂犬病ウイルスワクチン
US5738854A (en) * 1992-10-06 1998-04-14 Akzo Nobel N.V. Pseudorabies virus vaccine
ES2074965B1 (es) * 1994-01-31 1996-05-01 Hipra Lab Sa Virus mutante recombinante de rinotraqueitis infecciosa bovina y vacunas que lo contienen.
EP1985705A3 (de) 1994-06-17 2008-12-10 Instituut voor Dierhouderij en Diergezondheid Nukleotidsequenzen von Pestivirus-Stämmen, Polypeptide zur Kodierung dieser Sequenzen und deren Verwendung zur Diagnose und Verhinderung von Pestivirus-Infektionen
US6284251B1 (en) 1996-02-26 2001-09-04 Kansas State University Research Foundation BHV-1 gene-deleted virus vaccine
GB0126047D0 (en) * 2001-10-30 2001-12-19 Univ Cambridge Tech Therapeutic molecules
EP3943106A1 (de) 2014-03-03 2022-01-26 Albert Einstein College of Medicine Rekombinante herpes-simplex-virus (hsv-2)-impfstoffvektoren
US10918712B2 (en) 2014-03-03 2021-02-16 Albert Einstein College Of Medicine Passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors
WO2017106736A1 (en) * 2015-12-18 2017-06-22 Louisiana State University Research & Technology Foundation Pseudorabies virus (prv) vector expressing heterologous polypeptides
KR20210088655A (ko) * 2018-11-06 2021-07-14 베링거잉겔하임베트메디카게엠베하 조류 인플루엔자 바이러스 h5 서브타입에 대한 면역원성 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603112A (en) * 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
NL8303501A (nl) * 1983-10-12 1985-05-01 Centraal Diergeneeskundig Inst Deletiemutant van een herpesvirus en vaccin, dat dit virus bevat.
US4514497B1 (en) * 1983-12-30 1998-02-24 Novagene Inc Modified live pseudorabies viruses
US4703011A (en) * 1985-11-12 1987-10-27 Novagene, Inc. Thymidine kinase deletion mutants of bovine herpesvirus-1
US4711850A (en) * 1986-01-28 1987-12-08 Novagene, Inc. Pseudorabies virus mutants, vaccines containing same, methods for the production of same and methods for the use of same

Also Published As

Publication number Publication date
DK157087A (da) 1987-03-27
EP0231209A1 (de) 1987-08-12
WO1987000862A1 (en) 1987-02-12
NO301284B1 (no) 1997-10-06
FI871362A (fi) 1987-03-27
KR880700070A (ko) 1988-02-15
ATE60799T1 (de) 1991-02-15
AU591145B2 (en) 1989-11-30
JPH08333279A (ja) 1996-12-17
DK170948B1 (da) 1996-03-25
NO871313D0 (no) 1987-03-27
JPS63500449A (ja) 1988-02-18
IE861996L (en) 1987-01-29
KR950000887B1 (ko) 1995-02-03
ES2001752A6 (es) 1988-06-16
JP2559384B2 (ja) 1996-12-04
PH25776A (en) 1991-10-18
HK32696A (en) 1996-03-01
ZA865277B (en) 1987-03-25
CA1275625C (en) 1990-10-30
EP0231209B1 (de) 1991-02-06
US4810634A (en) 1989-03-07
CN86105450A (zh) 1987-03-04
IE59087B1 (en) 1994-01-12
NO871313L (no) 1987-03-27
CN1018845B (zh) 1992-10-28
JP2738524B2 (ja) 1998-04-08
AU5994886A (en) 1987-03-05
DK157087D0 (da) 1987-03-27
FI871362A0 (fi) 1987-03-27

Similar Documents

Publication Publication Date Title
DE3677494D1 (de) Virus-impfstoff.
GR3019112T3 (en) Porcine reproductive respiratory syndrome vaccine and diagnostic.
RU93058614A (ru) Мутант вируса герпеса, композиции, диагностические наборы, способы определения инфекции
HUP0000356A2 (hu) Hibás vírusgenomokon alapuló rekombináns vektorok és alkalmazásuk vakcinák kialakítására
BR0012433A (pt) Vìrus recombinante, infeccioso de doença bursal infecciosa, método para obter o mesmo, ibdv mosaico infeccioso (mibdv), e, vacina
ATE102650T1 (de) Mutanten des infektioesen bovinen rhinotracheitisvirus, vakzine die sie enthalten, verfahren zu ihrer herstellung und ihrer verwendung.
SE9202968D0 (sv) New peptides, diagnostic antigens, use thereof, vaccines and medicaments
DE69332264D1 (de) Mutanten des infektiösen rinder rhinotracheitis-virus und impfstoffe
ES2053477T3 (es) Vacuna viva para enfermedades contagiosas de pollos.
CA2012414A1 (en) Hog cholera virus vaccine and diagnostic
DE69333730D1 (de) Impfstoff, der acemannan als adjuvans enthält
ATE126274T1 (de) Rekombinanter impfstoff gegen marek's krankheit.
DK0623172T3 (da) Rekombinant Mareks sygdomsvirus-poxvirusvaccine
EP0496787A4 (en) Novel infectious bursal disease virus
ES2074965A1 (es) Virus mutante recombinante de rinotraqueitis infecciosa bovina y vacunas que lo contienen.
ES2105984A1 (es) Adenovirus recombinantes que expresan antigenos del virus de la gastroenteritis porcina transmisible (vgpt) y su empleo en la formacion de vacunas.
Joklik Antigenic relationships between the proteins of the three serotypes of reovirus.
Kaeberle et al. Infectious Bovine Rhinotracheitis Virus Antibody Responses to Vaccines Used in Combination

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA & UPJOHN CO., KALAMAZOO, MICH., US