DE3667977D1 - Tricyclische derivatevon thiadiazoloxiden. - Google Patents
Tricyclische derivatevon thiadiazoloxiden.Info
- Publication number
- DE3667977D1 DE3667977D1 DE8686302976T DE3667977T DE3667977D1 DE 3667977 D1 DE3667977 D1 DE 3667977D1 DE 8686302976 T DE8686302976 T DE 8686302976T DE 3667977 T DE3667977 T DE 3667977T DE 3667977 D1 DE3667977 D1 DE 3667977D1
- Authority
- DE
- Germany
- Prior art keywords
- 6alkyl
- 6alkoxy
- chr
- hydroxy
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004633 N-oxo-pyridyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000938 histamine H1 antagonist Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- -1 sulphonamido Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858510680A GB8510680D0 (en) | 1985-04-26 | 1985-04-26 | Pyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3667977D1 true DE3667977D1 (de) | 1990-02-08 |
Family
ID=10578260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8686302976T Expired - Lifetime DE3667977D1 (de) | 1985-04-26 | 1986-04-21 | Tricyclische derivatevon thiadiazoloxiden. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4668671A (de) |
| EP (1) | EP0200450B1 (de) |
| JP (1) | JPS61254585A (de) |
| AT (1) | ATE49212T1 (de) |
| DE (1) | DE3667977D1 (de) |
| GB (1) | GB8510680D0 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6365586B1 (en) * | 1998-10-21 | 2002-04-02 | Novo Nordisk A/S | Compounds, their preparation and use |
| JP6105585B2 (ja) * | 2011-08-16 | 2017-03-29 | アイカーン スクール オブ メディスン アット マウント サイナイＩｃａｈｎ Ｓｃｈｏｏｌ ｏｆ Ｍｅｄｉｃｉｎｅ ａｔ Ｍｔ． Ｓｉｎａｉ | 抗腫瘍剤としての三環式化合物 |
| RU2015139700A (ru) * | 2013-02-19 | 2017-03-27 | Икан Скул Оф Медсин Эт Маунт Синай | Трициклические гетероциклические соединения в качестве противораковых средств |
| CN103864765B (zh) * | 2014-03-05 | 2016-02-10 | 天津药物研究院 | 含有五元杂环的苯并氮杂卓类衍生物、其制备方法和用途 |
| EP3116860B1 (de) | 2014-03-11 | 2018-02-07 | Icahn School of Medicine at Mount Sinai | Aus tricyclyl-2-aminocycloalkanolen abgeleitete sulfonamide als antikrebsmittel |
| US9937180B2 (en) | 2014-03-11 | 2018-04-10 | Icahn School Of Medicine At Mount Sinai | Constrained tricyclic sulfonamides |
| WO2017044567A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents |
| CA2997784A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2837518A (en) * | 1958-06-03 | Phenthiazine compounds | ||
| US2974139A (en) * | 1954-10-02 | 1961-03-07 | Degussa | Thiophenylpyridyl amines |
| LU33901A1 (de) * | 1954-11-08 | |||
| GB814512A (en) * | 1956-08-01 | 1959-06-03 | Rhone Poulenc Sa | New phenthiazine derivatives and their preparation |
| NL100554C (de) * | 1958-04-19 | |||
| US3000885A (en) * | 1958-08-07 | 1961-09-19 | Searle & Co | 2-acyl-10-oxyalkylpiperidinoalkylphenothiazines and process |
| NL244514A (de) * | 1958-10-21 | |||
| GB1250534A (de) * | 1969-03-03 | 1971-10-20 | ||
| US3780059A (en) * | 1970-03-09 | 1973-12-18 | Squibb & Sons Inc | Dibenzooxazepines and dibenzothiazepines |
| FI76795C (fi) * | 1979-09-04 | 1988-12-12 | Bristol Myers Co | Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider samt nya mellanprodukter. |
| DE3175201D1 (en) * | 1980-04-30 | 1986-10-02 | Merck & Co Inc | Aminothiadiazoles as gastric secretion inhibitors |
| EP0065823A1 (de) * | 1981-05-13 | 1982-12-01 | Imperial Chemical Industries Plc | Heterozyklische Guanidinderivate als Histamin-H-2-Antagonisten |
| ATE19880T1 (de) * | 1981-08-24 | 1986-06-15 | Merck & Co Inc | Thiadiazole oxyde mit antisekretorischer wirkung. |
-
1985
- 1985-04-26 GB GB858510680A patent/GB8510680D0/en active Pending
-
1986
- 1986-04-21 AT AT86302976T patent/ATE49212T1/de not_active IP Right Cessation
- 1986-04-21 DE DE8686302976T patent/DE3667977D1/de not_active Expired - Lifetime
- 1986-04-21 EP EP86302976A patent/EP0200450B1/de not_active Expired - Lifetime
- 1986-04-23 US US06/854,951 patent/US4668671A/en not_active Expired - Fee Related
- 1986-04-25 JP JP61097812A patent/JPS61254585A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB8510680D0 (en) | 1985-06-05 |
| EP0200450A2 (de) | 1986-11-05 |
| EP0200450B1 (de) | 1990-01-03 |
| JPS61254585A (ja) | 1986-11-12 |
| EP0200450A3 (en) | 1988-09-07 |
| ATE49212T1 (de) | 1990-01-15 |
| US4668671A (en) | 1987-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |