DE3665669D1 - Multiphase tablet and process for the preparation thereof - Google Patents

Multiphase tablet and process for the preparation thereof

Info

Publication number
DE3665669D1
DE3665669D1 DE8686306216T DE3665669T DE3665669D1 DE 3665669 D1 DE3665669 D1 DE 3665669D1 DE 8686306216 T DE8686306216 T DE 8686306216T DE 3665669 T DE3665669 T DE 3665669T DE 3665669 D1 DE3665669 D1 DE 3665669D1
Authority
DE
Germany
Prior art keywords
salt
inflammatory
steroidal anti
narcotic analgesic
phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8686306216T
Other languages
German (de)
Inventor
Gordon Anthony Elger
Stewart Thomas Leslie
Sandra Therese Anoin Malkowska
Ronald Brown Miller
Philip John Neale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Application granted granted Critical
Publication of DE3665669D1 publication Critical patent/DE3665669D1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

A pharmaceutical composition in the form of a multiphase (especially a bilayered, optionally coated) tablet. The tablet has a narcotic analgesic phase containing a therapeutically effective quantity of a narcotic analgesic or an analgesically effective salt thereof (e.g. codeine phosphate) and a non-steroidal anti-inflammatory phase containing a therapeutically effective quantity of a non-steroidal anti-inflammatory carboxylic acid or an anti-inflammatory salt or ester thereof (e.g. ibuprofen). The narcotic analgesic phase is free from a non-steroidal anti-inflammatory carboxylic acid or salt or ester thereof, stearic acid and a.stearate salt, and the non-steroidal anti-inflammatory phase is free from a narcotic analgesic or salt thereof, stearic acid and a stearate salt. Further, both the narcotic analgesic phase and the non-steroidal anti-inflammatory phase contain a self-lubricating, compression aid, especially a self-lubricating, direct compression aid, such as microcrystalline cellulose.
DE8686306216T 1985-08-28 1986-08-12 Multiphase tablet and process for the preparation thereof Expired DE3665669D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858521350A GB8521350D0 (en) 1985-08-28 1985-08-28 Analgesic composition

Publications (1)

Publication Number Publication Date
DE3665669D1 true DE3665669D1 (en) 1989-10-26

Family

ID=10584346

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686306216T Expired DE3665669D1 (en) 1985-08-28 1986-08-12 Multiphase tablet and process for the preparation thereof

Country Status (13)

Country Link
US (1) US4844907A (en)
EP (1) EP0220805B1 (en)
JP (1) JPH0681733B2 (en)
AT (1) ATE46437T1 (en)
AU (1) AU584234B2 (en)
CA (1) CA1272955A (en)
DE (1) DE3665669D1 (en)
DK (1) DK175011B1 (en)
GB (1) GB8521350D0 (en)
IE (1) IE59515B1 (en)
NZ (1) NZ217341A (en)
SG (1) SG94892G (en)
ZA (1) ZA866207B (en)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8629567D0 (en) * 1986-12-10 1987-01-21 Boots Co Plc Therapeutic agents
EP0281200B1 (en) * 1987-03-02 1994-01-19 Yamanouchi Europe B.V. Pharmaceutical composition, pharmaceutical granulate and process for their preparation
JP2893191B2 (en) * 1988-11-08 1999-05-17 武田薬品工業株式会社 Controlled release matrix agent
US5085865A (en) * 1989-04-12 1992-02-04 Warner-Lambert Company Sustained release pharmaceutical preparations containing an analgesic and a decongestant
US5002774A (en) * 1989-06-08 1991-03-26 Erbamont, Inc. Sustained release pharmaceutical tablet
DE3927113C2 (en) * 1989-08-17 1993-11-25 Dolorgiet Gmbh & Co Kg Agent for the treatment of severe pain conditions and process for their preparation
US5213807A (en) * 1990-05-03 1993-05-25 Chemburkar Pramod B Pharmaceutical composition containing ibuprofen and a prostaglandin
US5164398A (en) * 1991-04-01 1992-11-17 Merck & Co., Inc. Ibuprofen-antitussive combinations
GB2260081B (en) * 1991-10-04 1995-11-29 Euro Celtique Sa Use of ibuprofen/codeine mixtures in treatment of chronic pain
GB9121204D0 (en) * 1991-10-04 1991-11-20 Euro Celtique Sa Medicament
US5266331A (en) * 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US5958459A (en) * 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
US5968551A (en) 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
DE69311394T2 (en) * 1992-02-20 1997-10-30 Euro Celtique Sa Delayed drug delivery
GB9203689D0 (en) * 1992-02-20 1992-04-08 Euro Celtique Sa Pharmaceutical composition
ES2059260B1 (en) * 1992-10-06 1995-04-16 Espanola Prod Quimicos PROCEDURE FOR THE PREPARATION OF TABLETS CONTAINING DICLOFENACO; DISPERSIBLE IN WATER.
US20080075781A1 (en) * 1992-11-25 2008-03-27 Purdue Pharma Lp Controlled release oxycodone compositions
IL119660A (en) * 1993-05-10 2002-09-12 Euro Celtique Sa Controlled release formulation comprising tramadol
DE4318577A1 (en) * 1993-06-04 1994-12-08 Merck Patent Gmbh Lubricant-free, medicament-containing tablets
US20070275062A1 (en) * 1993-06-18 2007-11-29 Benjamin Oshlack Controlled release oxycodone compositions
IL110014A (en) * 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
US7740881B1 (en) 1993-07-01 2010-06-22 Purdue Pharma Lp Method of treating humans with opioid formulations having extended controlled release
US5879705A (en) * 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
FR2708611B1 (en) * 1993-07-29 1995-10-27 Meram Lab Codeine salt of 2- (3-benzoylphenyl) propionic acid, process for obtaining it and pharmaceutical compositions containing it.
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6080428A (en) 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
KR100354702B1 (en) * 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 Manufacturing method and sustained release composition of pharmaceutical composition
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US6210714B1 (en) * 1993-11-23 2001-04-03 Euro-Celtique S.A. Immediate release tablet cores of acetaminophen having sustained-release coating
US5843480A (en) * 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
IT1270239B (en) * 1994-06-17 1997-04-29 Zambon Spa SOLID PHARMACEUTICAL COMPOSITION CONTAINING ACID (S) -2- (4- ISOBUTYLPHENYL) PROPIONIC AS ACTIVE INGREDIENT
US5529787A (en) * 1994-07-07 1996-06-25 Alza Corporation Hydromorphone therapy
US5914131A (en) * 1994-07-07 1999-06-22 Alza Corporation Hydromorphone therapy
US6491945B1 (en) * 1994-09-16 2002-12-10 Alza Corporation Hydrocodone therapy
GB9422154D0 (en) * 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US5648358A (en) * 1996-03-05 1997-07-15 Mitra; Sekhar Compositions and methods for treating respiratory disorders
WO1997033566A2 (en) * 1996-03-12 1997-09-18 Alza Corporation Composition and dosage form comprising opioid antagonist
US5858409A (en) * 1996-04-17 1999-01-12 Fmc Corporation Hydrolyzed cellulose granulations for pharmaceuticals
US6348216B1 (en) * 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
US6361794B1 (en) * 1996-06-12 2002-03-26 Basf Corporation Method of making ibuprofen and narcotic analgesic composition
US5837292A (en) * 1996-07-03 1998-11-17 Yamanouchi Europe B.V. Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
GB9705989D0 (en) * 1997-03-22 1997-05-07 Boots Co Plc Therapeutic composition
RS49982B (en) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Synergistic analgesic combination of opioid analgesic and cyclooxygenase-2 inhibitor
RU2241458C2 (en) 1997-12-22 2004-12-10 Эро-Селтик, С.А. Combinations of agonist/antagonist for opioid
CN1204890C (en) * 1997-12-22 2005-06-08 欧罗赛铁克股份有限公司 Method for preventing abuse of opioid dosage forms
ES2277682T3 (en) * 1998-06-11 2007-07-16 PHARMACIA & UPJOHN COMPANY LLC FORMULATION OF DELAVIRDINE IN COMPRESSED.
US6197347B1 (en) 1998-06-29 2001-03-06 Andrx Pharmaceuticals, Inc. Oral dosage for the controlled release of analgesic
US6806294B2 (en) 1998-10-15 2004-10-19 Euro-Celtique S.A. Opioid analgesic
DE19918325A1 (en) 1999-04-22 2000-10-26 Euro Celtique Sa Extruded drug dosage form, e.g. granulate for tableting, comprising an active agent in a polysaccharide-containing matrix, giving a release profile which is controllable by extrusion conditions and/or the inclusion of additives
DE19927689A1 (en) * 1999-06-17 2000-12-21 Gruenenthal Gmbh Oral dosage formulation containing tramadol and diclofenac, useful for treating pain, contains the active ingredients in separate subunits
DE19927688A1 (en) * 1999-06-17 2000-12-21 Gruenenthal Gmbh Multi-layered tablet containing tramadole and diclofenac, useful for treating pain, has separating layer between active ingredient layers
FI109453B (en) * 1999-06-30 2002-08-15 Orion Yhtymae Oyj Pharmaceutical composition
EP2295043A1 (en) 1999-10-29 2011-03-16 Euro-Celtique S.A. Controlled release hydrocodone formulations
JP2003522144A (en) 2000-02-08 2003-07-22 ユーロ−セルティーク，エス．エイ． Controlled release compositions comprising opioid agonists and antagonists
CN101317825A (en) 2000-10-30 2008-12-10 欧罗赛铁克股份有限公司 Controlled release hydrocodone formulations
HUP0303178A3 (en) * 2001-02-05 2008-03-28 R P Scherer Technologies Methods and compositions for reducing the taste of pharmaceutically active agents
UA81224C2 (en) * 2001-05-02 2007-12-25 Euro Celtic S A Dosage form of oxycodone and use thereof
CN1525851A (en) 2001-05-11 2004-09-01 ������ҩ�����޹�˾ Abuse-resistant controlled-release opioid dosage form
EP2311460A1 (en) * 2001-07-06 2011-04-20 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
US8329216B2 (en) * 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
SI1416842T1 (en) 2001-07-18 2009-06-30 Euro Celtique Sa Pharmaceutical combinations of oxycodone and naloxone
DE60234057D1 (en) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc COMPOSITIONS AND METHODS FOR MODULATING TRANSPORT BY THE BLOOD-BRAIN BARRIER
US20030157168A1 (en) 2001-08-06 2003-08-21 Christopher Breder Sequestered antagonist formulations
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
ES2326794T3 (en) 2001-08-06 2009-10-20 Euro-Celtique S.A. FORMULATIONS OF OPIOID AGONISTS WITH LIBERABLE AND SEQUESTED ANTAGONISTS.
CA2459976A1 (en) * 2001-09-26 2003-04-03 Penwest Pharmaceuticals Company Opioid formulations having reduced potential for abuse
ES2546010T3 (en) 2002-04-05 2015-09-17 Euro-Celtique S.A. Pharmaceutical preparation containing oxycodone and naloxone
US6667100B2 (en) * 2002-05-13 2003-12-23 Egc Enterprises, Inc. Ultra-thin flexible expanded graphite heating element
PT1551372T (en) * 2002-09-20 2018-07-23 Alpharma Pharmaceuticals Llc Sequestering subunit and related compositions and metohds
US7090859B2 (en) * 2002-12-13 2006-08-15 Ronald Thomas Haas Ketoprofen compositions and methods of making them
US20040166160A1 (en) * 2003-01-14 2004-08-26 Ramkumar Subramanian Methods and dosage forms with modified viscosity layers
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
MY135852A (en) * 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
MXPA06003450A (en) 2003-09-26 2006-08-31 Johnson & Johnson Drug coating providing high drug loading and methods for providing the same.
AU2004275835B2 (en) * 2003-09-26 2011-06-23 Alza Corporation Controlled release formulations exhibiting an ascending rate of release
WO2005030166A1 (en) * 2003-09-26 2005-04-07 Alza Corporation Oros push-stick for controlled delivery of active agents
US20050158382A1 (en) * 2003-09-26 2005-07-21 Evangeline Cruz Controlled release formulations of opioid and nonopioid analgesics
US20050079221A1 (en) * 2003-10-10 2005-04-14 Groenewoud Pieter Jurjen Ibuprofen narcotic composition and method for making same
US20050266032A1 (en) * 2003-12-17 2005-12-01 Sovereign Pharmaceuticals, Ltd. Dosage form containing multiple drugs
EP1738754B1 (en) * 2004-04-14 2015-07-15 Takeda Pharmaceutical Company Limited Solid pharmaceutical preparation
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
US9265732B2 (en) * 2006-03-06 2016-02-23 Pozen Inc. Dosage forms for administering combinations of drugs
JP5349059B2 (en) * 2006-03-06 2013-11-20 ポーゼン インコーポレイテッド Dosage form for administering a combination of drugs
US20070212414A1 (en) * 2006-03-08 2007-09-13 Penwest Pharmaceuticals Co. Ethanol-resistant sustained release formulations
PL2526932T3 (en) 2006-06-19 2017-12-29 Alpharma Pharmaceuticals Llc Pharmaceutical composition
US8765178B2 (en) * 2006-07-19 2014-07-01 Watson Laboratories, Inc. Controlled release formulations and associated methods
WO2008011596A2 (en) * 2006-07-21 2008-01-24 Lab International Srl Hydrophilic abuse deterrent delivery system
CA2663377A1 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
GB0625646D0 (en) * 2006-12-21 2007-01-31 Jagotec Ag Improvements in or relating to organic compounds
US20080305159A1 (en) * 2007-06-06 2008-12-11 Mikart, Inc. Ibuprofen-Hydrocodone-Antihistamine Composition
US20090124650A1 (en) * 2007-06-21 2009-05-14 Endo Pharmaceuticals, Inc. Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instructions on Effects of Alcohol
GB0714790D0 (en) * 2007-07-30 2007-09-12 Jagotec Ag Improvements in or relating to organic compounds
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
US20090246276A1 (en) 2008-01-28 2009-10-01 Graham Jackson Pharmaceutical Compositions
US20090264454A1 (en) * 2008-04-16 2009-10-22 Nickell Robert P Combined hydrocodone and analgesic formulation and method
US8491930B2 (en) 2008-04-23 2013-07-23 Farmasierra Manufacturing, S.L. Pharmaceutical formulation containing ibuprofen and codeine
EP2398500B1 (en) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Glutathione-based drug delivery system
SG174286A1 (en) 2009-03-10 2011-10-28 Euro Celtique Sa Immediate release pharmaceutical compositions comprising oxycodone and naloxone
ES2823249T3 (en) 2009-03-12 2021-05-06 Cumberland Pharmaceuticals Inc Ibuprofen administration intravenously
SG10201402069PA (en) 2009-05-06 2014-07-30 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20130115250A1 (en) * 2009-05-13 2013-05-09 Wyeth Llc Burst Drug Release Compositions
ES2365961B1 (en) 2010-03-30 2013-01-24 Farmasierra Manufacturing S.L. PHARMACEUTICAL FORMULATION BASED ON IBUPROFEN AND IMPROVED STABILITY CODEINE.
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
EP2694079B1 (en) * 2011-04-06 2018-01-17 Rutgers, The State University of New Jersey Polymers and methods for the treatment of pain
WO2013112456A1 (en) 2012-01-24 2013-08-01 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Controlled release formulations for the induction and proliferation of blood cells
US9072710B2 (en) 2012-03-16 2015-07-07 Cumberland Pharmaceuticals Inc. Injectable ibuprofen formulation
NZ716267A (en) 2013-07-23 2017-05-26 Euro Celtique Sa A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
CN110913850A (en) * 2017-09-15 2020-03-24 晶体基因技术株式会社 Pharmaceutical composition for treating acute and chronic pain containing pamecoxib and tramadol

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2738303A (en) * 1952-07-18 1956-03-13 Smith Kline French Lab Sympathomimetic preparation
GB818251A (en) * 1957-04-24 1959-08-12 British Drug Houses Ltd Silicone talc tablet lubricant
GB1311286A (en) * 1969-12-05 1973-03-28 Wild H Compositions for the relief of migraine
US3558768A (en) * 1969-12-19 1971-01-26 Sterling Drug Inc Sustained release pharmaceutical compositions
GB1405088A (en) 1971-06-03 1975-09-03 Mundipharma Ag Slow release formulation
FR2183546B1 (en) * 1972-05-10 1975-06-20 Servier Lab
US3965256A (en) 1972-05-16 1976-06-22 Synergistics Slow release pharmaceutical compositions
US4017641A (en) * 1975-01-31 1977-04-12 The Procter & Gamble Company Skin moisturizing compositions containing 2-pyrrolidinone
EP0024690B1 (en) * 1979-08-23 1983-07-20 E.I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof
US4282215A (en) * 1980-06-17 1981-08-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof
DE3273329D1 (en) * 1981-06-26 1986-10-23 Upjohn Co Analgesic process and composition
DK150008C (en) * 1981-11-20 1987-05-25 Benzon As Alfred PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL ORAL POLYDEPOT PREPARATION
CA1261260A (en) * 1984-04-16 1989-09-26 Anil Salpekar Directly compressible codeine salt compositions
US4569937A (en) * 1985-02-11 1986-02-11 E. I. Du Pont De Nemours And Company Analgesic mixture of oxycodone and ibuprofen
US4601894A (en) * 1985-03-29 1986-07-22 Schering Corporation Controlled release dosage form comprising acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate

Also Published As

Publication number Publication date
IE862177L (en) 1987-02-28
US4844907A (en) 1989-07-04
DK407286A (en) 1987-03-01
ZA866207B (en) 1987-04-29
JPS6251625A (en) 1987-03-06
IE59515B1 (en) 1994-03-09
AU6183086A (en) 1987-03-05
EP0220805A3 (en) 1987-07-29
GB8521350D0 (en) 1985-10-02
EP0220805A2 (en) 1987-05-06
NZ217341A (en) 1988-10-28
ATE46437T1 (en) 1989-10-15
DK175011B1 (en) 2004-04-26
SG94892G (en) 1992-12-04
CA1272955A (en) 1990-08-21
AU584234B2 (en) 1989-05-18
DK407286D0 (en) 1986-08-27
EP0220805B1 (en) 1989-09-20
JPH0681733B2 (en) 1994-10-19

Similar Documents

Publication Publication Date Title
DE3665669D1 (en) Multiphase tablet and process for the preparation thereof
US5696165B1 (en) Composition of s(-) sodium ibuprofen
JPS6431729A (en) Novel use for 5ht-3 antagonist
IL76932A (en) Synergistic pharmaceutical analgesic compositions containing dihydrocodeine and ibuprofen
LV10684A (en) Regular release of morphine islet containing content
GB1517480A (en) Opiate analgesic formulation with a low potential for abuse
NZ319531A (en) An analgesic synergistic composition containing a sub-analgesic dose of a mu opioid agonist and a kappa-2 opiod agonist
PT81583A (en) Process for the preparation of analgesic pharmaceutical compositions containing buprenorphine and natrexone
IL103303A (en) Pharmaceutical compositions containing ibuprofen and codeine for relief of chronic pain
EG17609A (en) Process for preparation of therapeutic agents from derivatives of propoimic acid.
GB1390772A (en) Oral narcotic composition
GEP19991686B (en) Pharmaceutical Composition for Obtaining Effervescent Powder or Tablet, Pharmaceutical Preparation and Method for Preparing Same
IL77780A (en) Pharmaceutical analgesic compositions containing diclofenac and codeine and their preparation
HUP9900568A3 (en) Morphine and diamorphine salts of non-narcotic analgesics of the phenylalkyl carboxylic acid type, process for their preparation, their use and pharmaceutical compositions containing them
MX9709838A (en) Stable pharmaceutical compositions containing tiludronate hydrates and process for producing the pharmaceutical compositions.
EP0805157A4 (en) Indole derivatives and medicinal use thereof
CA2136071A1 (en) 2-arylpropionic acid compositions and process for preparing the same
GEP20043286B (en) Dual Inhibitors of Cholesteryl Ester and Wax Ester Synthesis for Sebaceous Gland Disorders
EP0345883A3 (en) Use of dapiprazole for the manufacture of a pharmaceutical composition inhibiting the development of tolerance in the analgesic treatment with morphine
IL60901A (en) Synergistic analgesic pharmaceutical compositions containing nalbuphine and acetylsalicyclic acid derivatives
GB1261454A (en) Improved analgesic systems and compositions
DE3571394D1 (en) A (-) campholenic acid ester of salicylic acid having mucosecretolytic, anti-inflammatory, analgesic antipyretic activity, suitable to provide pharmaceutically acceptable salts; a process for its preparation and pharmaceutical compositions containing the ester or the salts thereof
ZA811105B (en) Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids, novel carboxylic acis salts and the production thereof

Legal Events

Date Code Title Description
8364 No opposition during term of opposition