DE3661356D1 - Indene and naphthalene derivatives - Google Patents

Indene and naphthalene derivatives

Info

Publication number
DE3661356D1
DE3661356D1 DE8686200495T DE3661356T DE3661356D1 DE 3661356 D1 DE3661356 D1 DE 3661356D1 DE 8686200495 T DE8686200495 T DE 8686200495T DE 3661356 T DE3661356 T DE 3661356T DE 3661356 D1 DE3661356 D1 DE 3661356D1
Authority
DE
Germany
Prior art keywords
indene
naphthalene derivatives
naphthalene
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8686200495T
Other languages
English (en)
Inventor
Robert Thomas Logan
James Redpath
Robert Gibson Roy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Application granted granted Critical
Publication of DE3661356D1 publication Critical patent/DE3661356D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/20—Polycyclic condensed hydrocarbons
    • C07C15/24—Polycyclic condensed hydrocarbons containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8686200495T 1985-04-02 1986-03-24 Indene and naphthalene derivatives Expired DE3661356D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858508588A GB8508588D0 (en) 1985-04-02 1985-04-02 Indene & napthalene derivatives

Publications (1)

Publication Number Publication Date
DE3661356D1 true DE3661356D1 (de) 1989-01-12

Family

ID=10577079

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686200495T Expired DE3661356D1 (de) 1985-04-02 1986-03-24 Indene and naphthalene derivatives

Country Status (14)

Country Link
US (1) US4705782A (de)
EP (1) EP0199393B1 (de)
JP (1) JPS61246152A (de)
KR (1) KR860008111A (de)
AU (1) AU593793B2 (de)
CA (1) CA1312871C (de)
DE (1) DE3661356D1 (de)
DK (1) DK139286A (de)
ES (1) ES8800122A1 (de)
FI (1) FI82928C (de)
GB (1) GB8508588D0 (de)
GR (1) GR860779B (de)
PT (1) PT82319B (de)
ZA (1) ZA862280B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661522A (en) * 1984-05-24 1987-04-28 Akzo N.V. Cycloalkane-indene-carboximidamide derivatives
US4882354A (en) * 1987-12-16 1989-11-21 Norwich Eaton Pharmaceuticals, Inc. N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
US4870210A (en) * 1987-12-18 1989-09-26 American Home Products Corporation Aminoguanidine derivative as anti-inflammatory agents
DE68901424D1 (de) * 1988-07-05 1992-06-11 Akzo Nv Verbindungen mit bronchodilatatorischer aktivitaet.
US4981865A (en) * 1989-05-26 1991-01-01 Warner-Lambert Co. N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents
US5093356A (en) * 1990-01-16 1992-03-03 Merck Frosst Canada, Inc. Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
US5028629A (en) * 1990-03-28 1991-07-02 Eli Lilly And Company 5-Lipoxygenase inhibitors
IE913683A1 (en) * 1990-10-26 1992-05-22 Akzo Nv USE OF A BENZO[b]THIOPHENE-2-CARBOXIMIDAMIDE DERIVATIVE
US5276052A (en) * 1990-10-26 1994-01-04 Akzo N.V. Use of a benzo[b]thiopene-2-carboximidamide derivative
DE19736921A1 (de) * 1997-08-25 1999-03-04 Bayer Ag Verfahren zur Herstellung von 2-Cyanoindan-1-onen
WO2012149540A1 (en) 2011-04-28 2012-11-01 The Broad Institute Inc Inhibitors of histone deacetylase
JP6337255B2 (ja) 2012-07-27 2018-06-06 ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. ヒストンデアセチラーゼの阻害剤
WO2014100438A1 (en) * 2012-12-20 2014-06-26 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB304441A (en) * 1927-12-19 1929-01-24 Ig Farbenindustrie Ag The manufacture of naphthol ether carboxy-amides and aminonaphthol ethers
US3130232A (en) * 1963-02-12 1964-04-21 Upjohn Co Amidinohydrazones of cyclic halovinyl aldehydes
US3530165A (en) * 1967-12-08 1970-09-22 Du Pont Pharmaceutically active 4 - phenylbicyclo(2.2.2)-octane and oct-2-ene-1-carboxamides and derivatives thereof
US3560519A (en) * 1969-03-28 1971-02-02 Sinclair Research Inc Aromatic mono(nitrile carbonates)
US3829467A (en) * 1972-07-03 1974-08-13 Rorer Inc William H Tetrahydronaphthylalkanoic acids and their derivatives
JPS5623982B2 (de) * 1972-12-07 1981-06-03
US4013682A (en) * 1973-08-03 1977-03-22 Akzona Incorporated N-hydroxy-amidine compounds
CH601166A5 (de) * 1974-02-14 1978-06-30 Ciba Geigy Ag
NL7407469A (nl) * 1974-06-01 1975-12-03 Akzo Nv Nieuwe amidinohydrazonverbindingen.
DE2620369C3 (de) * 1976-05-08 1979-01-04 Bayer Ag, 5090 Leverkusen Verfahren zur Wiedergewinnung von (l-S)-2-Oxo-bornansulfonat-(10)
DE2804576A1 (de) * 1977-02-15 1978-08-17 Lafon Labor Phenylamidin-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE2824409A1 (de) * 1977-06-13 1978-12-21 Degussa 5,6,7-trimethoxy-naphthalin-(2)-carbonsaeure- und -hydronaphthalin-(2)-carbonsaeure-derivate sowie verfahren zu ihrer herstellung
NL7908922A (nl) * 1979-12-12 1981-07-16 Akzo Nv Carboximidamide derivaten.
JPS57179147A (en) * 1981-04-28 1982-11-04 Torii Yakuhin Kk Amidine derivative
EP0087218B1 (de) * 1982-02-10 1985-05-02 Beecham Group Plc Guanidinderivate
EP0097463A3 (de) * 1982-06-16 1985-05-15 Beecham Group Plc Amidin-Derivate
US4661522A (en) * 1984-05-24 1987-04-28 Akzo N.V. Cycloalkane-indene-carboximidamide derivatives
US4604407A (en) * 1985-04-04 1986-08-05 E. R. Squibb & Sons, Inc. Hydroxamates
US4608390A (en) * 1985-04-26 1986-08-26 Abbott Laboratories Lipoxygenase inhibiting compounds
US4605669A (en) * 1985-04-26 1986-08-12 Abbott Laboratories Lipoxygenase inhibiting naphthohydroxamic acids

Also Published As

Publication number Publication date
DK139286A (da) 1986-10-03
ES8800122A1 (es) 1987-10-16
PT82319B (pt) 1988-03-03
EP0199393B1 (de) 1988-12-07
FI861379A (fi) 1986-10-03
ZA862280B (en) 1986-11-26
GB8508588D0 (en) 1985-05-09
AU593793B2 (en) 1990-02-22
CA1312871C (en) 1993-01-19
FI861379A0 (fi) 1986-04-01
FI82928B (fi) 1991-01-31
US4705782A (en) 1987-11-10
FI82928C (fi) 1991-05-10
DK139286D0 (da) 1986-03-25
JPS61246152A (ja) 1986-11-01
KR860008111A (ko) 1986-11-12
GR860779B (en) 1986-06-24
EP0199393A1 (de) 1986-10-29
PT82319A (en) 1986-05-01
ES553601A0 (es) 1987-10-16
AU5539686A (en) 1986-10-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AKZO NOBEL N.V., ARNHEIM/ARNHEM, NL

8339 Ceased/non-payment of the annual fee