DE3587465D1 - Vielfache drogen-resistenz in saeugetierzellinien und isolierung der determinanten glykoprotein-dns. - Google Patents

Vielfache drogen-resistenz in saeugetierzellinien und isolierung der determinanten glykoprotein-dns.

Info

Publication number
DE3587465D1
DE3587465D1 DE8585306331T DE3587465T DE3587465D1 DE 3587465 D1 DE3587465 D1 DE 3587465D1 DE 8585306331 T DE8585306331 T DE 8585306331T DE 3587465 T DE3587465 T DE 3587465T DE 3587465 D1 DE3587465 D1 DE 3587465D1
Authority
DE
Germany
Prior art keywords
mammaline
determinant
isolation
cell lines
drug resistance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585306331T
Other languages
English (en)
Other versions
DE3587465T2 (de
Inventor
John R Riordan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hsc Research Development Corp
Original Assignee
Hsc Research Development Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848422819A external-priority patent/GB8422819D0/en
Application filed by Hsc Research Development Corp filed Critical Hsc Research Development Corp
Application granted granted Critical
Publication of DE3587465D1 publication Critical patent/DE3587465D1/de
Publication of DE3587465T2 publication Critical patent/DE3587465T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
DE85306331T 1984-09-10 1985-09-05 Vielfache Drogen-Resistenz in Säugetierzellinien und Isolierung der determinanten Glykoprotein-DNS. Expired - Fee Related DE3587465T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848422819A GB8422819D0 (en) 1984-09-10 1984-09-10 Multidrug resistance in mammalian cells
CA000489897A CA1290712C (en) 1984-09-10 1985-09-03 Multidrug resistance in mammalian cell lines and isolation of determinant glycoprotein dna

Publications (2)

Publication Number Publication Date
DE3587465D1 true DE3587465D1 (de) 1993-08-26
DE3587465T2 DE3587465T2 (de) 1994-01-20

Family

ID=25670775

Family Applications (1)

Application Number Title Priority Date Filing Date
DE85306331T Expired - Fee Related DE3587465T2 (de) 1984-09-10 1985-09-05 Vielfache Drogen-Resistenz in Säugetierzellinien und Isolierung der determinanten Glykoprotein-DNS.

Country Status (3)

Country Link
US (1) US4912039A (de)
EP (1) EP0174810B1 (de)
DE (1) DE3587465T2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837306A (en) * 1985-02-25 1989-06-06 The Ontario Cancer Institute Method for selecting hybridomas producing antibodies specific to the P-glycoprotein cell suface antigen and a cDNA clone encoding the C-terminal portion of the antigen
US5206352A (en) * 1986-03-28 1993-04-27 Board Of Trustees Of The University Of Illinois Compositions for clones containing DNA sequences associated with multidrug resistance in human cells
DE3751307T2 (de) * 1986-03-28 1995-09-21 Univ Illinois Zubereitungen und verfahren für klone, die, mit mehrfacharzneimittelresistenz assoziierte, dna-sequenzen in menschlichen zellen enthalten.
US5166059A (en) * 1987-06-16 1992-11-24 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy using gene fusions for genetic or acquired disorders
US5928637A (en) * 1987-06-16 1999-07-27 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods of inducing multidrug resistance using human MDR1 cDNA
US5851819A (en) * 1987-06-16 1998-12-22 National Institutes Of Health Vectors carrying MDR1 cDNA which confer multidrug resistance on transduced cells
EP0378383A3 (de) * 1989-01-10 1991-09-11 ARIZONA BOARD OF REGENTS, on behalf of THE UNIVERSITY OF ARIZONA Verfahren und Gerät zum Nachweis, zur Gültigkeitserklärung und Quantifizierung von mit Vielfachdrogen Widerstand assoziierten Antigenen
US5399483A (en) * 1989-03-30 1995-03-21 Suntory Limited Expression of MDR-related gene in yeast cell
ATE160379T1 (de) * 1990-10-29 1997-12-15 Chiron Corp Bispezifische antikörper, verfahren zu ihrer herstellung und deren verwendungen
US5849877A (en) * 1990-10-29 1998-12-15 Chiron Corporation Antigen-binding sites of antibody molecules specific for cancer antigens
US5948647A (en) * 1990-10-29 1999-09-07 Chiron Corporation Nucleic acids encoding antigen-binding sites specific for cancer antigens
US5811267A (en) * 1990-10-29 1998-09-22 Chiron Corporation Isolated nucleic acid molecules encoding antigen binding sites of antibody molecules specific for cancer antigens
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
EP0646171A4 (de) * 1992-05-22 1998-01-07 Us Health Eine verbesserte methode zur expression von menschlichen "multidrug-resistance" genen und eine verbesserte selektion für zellen welche mit diesen genen transduziert wurden.
US5766880A (en) * 1992-10-27 1998-06-16 Queen's University At Kingston Isolated nucleic acid molecules encoding multidrug resistance proteins
US6063621A (en) * 1992-10-27 2000-05-16 Queen's University At Kingston Antibodies to a multidrug resistance protein
US5891724A (en) * 1992-10-27 1999-04-06 Queen's University At Kingston Methods for conferring multidrug resistance on a cell
US6025473A (en) * 1992-10-27 2000-02-15 Queen's University At Kingston Multidrug resistance proteins
US6001563A (en) * 1992-10-27 1999-12-14 Queen's University At Kingston Methods for identifying chemosensitizers
US5882875A (en) * 1992-10-27 1999-03-16 Queen's University At Kingston Methods for identifying multidrug resistant tumor cells
US5489519A (en) * 1992-10-27 1996-02-06 Queen's University At Kingston Multidrug resistance protein
US20030086922A1 (en) * 1994-12-02 2003-05-08 David B. Ring Method of promoting an immune response with a bispecific antibody
US5914246A (en) * 1996-03-08 1999-06-22 Eli Lilly And Company Multiple drug resistance gene of Aspergillus fumigatus
DE60140868D1 (de) 2000-06-05 2010-02-04 Brigham & Womens Hospital Für ein homologes des humanen, für mehrfachresistenz verantwortlichen, p-glykoproteins auf chromosom 7p15-21 kodierendes gen sowie verwendungen dafür
US6630454B2 (en) * 2001-09-10 2003-10-07 Ramot At Tel-Aviv University Ltd. Method and pharmaceutical composition for the treatment of cancer
AU2003256847A1 (en) * 2002-07-26 2004-02-16 Advanced Research And Technology Institute At Indiana University Method of treating cancer
US20060263834A1 (en) * 2005-02-25 2006-11-23 Hematologics, Inc. Functional multi-drug resistance assay
ES2511791T3 (es) 2006-05-31 2014-10-23 Children's Medical Center Corporation Células madre mesenquimales positivas para ABCB5 como moduladoras de inmunidad
CA2718573C (en) 2007-04-12 2020-07-14 The Brigham And Women's Hospital, Inc. Targeting abcb5 for cancer therapy
US11542328B2 (en) 2008-11-14 2023-01-03 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
CA2743464A1 (en) 2008-11-14 2010-05-20 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells

Also Published As

Publication number Publication date
DE3587465T2 (de) 1994-01-20
EP0174810A3 (en) 1987-11-25
EP0174810A2 (de) 1986-03-19
US4912039A (en) 1990-03-27
EP0174810B1 (de) 1993-07-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee