DE3570867D1 - Carbacyclin analogues - Google Patents

Carbacyclin analogues

Info

Publication number
DE3570867D1
DE3570867D1 DE8585301533T DE3570867T DE3570867D1 DE 3570867 D1 DE3570867 D1 DE 3570867D1 DE 8585301533 T DE8585301533 T DE 8585301533T DE 3570867 T DE3570867 T DE 3570867T DE 3570867 D1 DE3570867 D1 DE 3570867D1
Authority
DE
Germany
Prior art keywords
carbacyclin analogues
carbacyclin
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585301533T
Other languages
English (en)
Inventor
Paul Adrian Aristoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/690,803 external-priority patent/US4668814A/en
Priority claimed from US06/690,804 external-priority patent/US4683330A/en
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DE3570867D1 publication Critical patent/DE3570867D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8585301533T 1984-03-08 1985-03-06 Carbacyclin analogues Expired DE3570867D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58733784A 1984-03-08 1984-03-08
US58733684A 1984-03-08 1984-03-08
US06/690,803 US4668814A (en) 1984-03-08 1985-01-11 Interphenylene carbacyclin derivatives
US06/690,804 US4683330A (en) 1984-03-08 1985-01-11 Interphenylene carbacyclin derivatives

Publications (1)

Publication Number Publication Date
DE3570867D1 true DE3570867D1 (de) 1989-07-13

Family

ID=27504980

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585301533T Expired DE3570867D1 (de) 1984-03-08 1985-03-06 Carbacyclin analogues

Country Status (3)

Country Link
EP (1) EP0159784B1 (de)
CA (1) CA1241324A (de)
DE (1) DE3570867D1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902811A (en) * 1987-07-01 1990-02-20 Shionogi & Co., Ltd. Benzodioxane prostacyclin analogs
GB2237018A (en) * 1989-08-18 1991-04-24 Medeva Plc Secondary alcohols and compositions containing fatty acids or esters
US6521212B1 (en) 1999-03-18 2003-02-18 United Therapeutics Corporation Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
EP1354588A1 (de) * 1999-03-18 2003-10-22 United Therapeutics Corporation et al Verfahren zur Abgabe von Benzidenprostaglandin durch Inhalation
CN101780092B (zh) 2003-05-22 2012-07-04 联合治疗公司 化合物和释放前列环素类似物的方法
DE602004028155D1 (de) 2003-12-16 2010-08-26 United Therapeutics Corp Verwendung von treprostinil zur behandlung von ischämischen läsionen
US20090124697A1 (en) 2003-12-16 2009-05-14 United Therapeutics Corporation Inhalation formulations of treprostinil
EP1744739B1 (de) 2004-04-12 2010-03-31 United Therapeutics Corporation Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren
CA2710205C (en) 2007-12-17 2016-04-26 United Therapeutics Corporation An improved process to prepare treprostinil, the active ingredient in remodulin
EP2576492B1 (de) 2010-06-03 2017-09-20 United Therapeutics Corporation Treprostinilherstellung
CN103476762B (zh) 2011-03-02 2015-04-22 联合治疗公司 用于生产曲前列环素的中间体的合成
WO2013024051A1 (en) 2011-08-12 2013-02-21 Ascendis Pharma A/S Sustained release composition of prostacyclin
JP6092867B2 (ja) 2011-08-12 2017-03-08 アセンディス ファーマ エー／エス 担体連結しているトレプロスチニルプロドラッグ
KR102347340B1 (ko) 2013-03-14 2022-01-06 유나이티드 세러퓨틱스 코오포레이션 트레프로스티닐의 고체 형태
ES2778274T3 (es) 2014-10-20 2020-08-10 United Therapeutics Corp Síntesis de productos intermedios para producir derivados de prostaciclina
US10632129B2 (en) 2014-12-03 2020-04-28 Steadymed Ltd. Preservative-free treprostinil formulations and methods and devices for use with same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3781429A (en) 1972-09-29 1973-12-25 American Cyanamid Co Method of inhibiting ulcerogenesis induced by non-steroidal anti-inflammatory agents
US3868691A (en) 1973-04-13 1975-02-25 Epsco Inc Loran receiver automated master search
US3980694A (en) * 1974-04-11 1976-09-14 The Upjohn Company 4-Oxa phenyl-substituted PGA compounds
US4016184A (en) 1975-09-17 1977-04-05 The Upjohn Company 9-Deoxy-9,10-didehydro-PGD1 compounds
US4073808A (en) 1975-12-29 1978-02-14 The Upjohn Company 2-Decarboxy-2-amino-methyl-PGA and 9-deoxy-9,10-didehydro-PGD analogs
US4029681A (en) 1976-02-13 1977-06-14 The Upjohn Company 13,14-Didehydro-PG analogs
US4103026A (en) 1976-08-23 1978-07-25 Carlson Lars A Treatment of peripheral vascular disease by non-intraarterial administration of prostaglandin E1
US4125544A (en) * 1977-06-09 1978-11-14 G. D. Searle 20/22/23/24-Oxa-7-oxocholesterols and esters thereof
JPS5436240A (en) * 1977-08-04 1979-03-16 Squibb & Sons Inc Production of hydronaphthalene derivative
JPS5931510B2 (ja) 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
US4259240A (en) * 1979-09-28 1981-03-31 Advance Biofactures Corporation Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom
US4306075A (en) 1980-03-28 1981-12-15 The Upjohn Company Composition and process
GB2121802B (en) * 1980-03-28 1985-01-16 Upjohn Co Benzo-fused carbacyclin analogues
US4306076A (en) 1980-04-23 1981-12-15 The Upjohn Company Inter-phenylene CBA compounds
DE3121155A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
US4401824A (en) 1982-03-08 1983-08-30 The Upjohn Company Benzopyran compounds, derivatives of prostaglandins

Also Published As

Publication number Publication date
EP0159784A1 (de) 1985-10-30
EP0159784B1 (de) 1989-06-07
CA1241324A (en) 1988-08-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee