DE3570078D1 - Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds - Google Patents
Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compoundsInfo
- Publication number
- DE3570078D1 DE3570078D1 DE8585306479T DE3570078T DE3570078D1 DE 3570078 D1 DE3570078 D1 DE 3570078D1 DE 8585306479 T DE8585306479 T DE 8585306479T DE 3570078 T DE3570078 T DE 3570078T DE 3570078 D1 DE3570078 D1 DE 3570078D1
- Authority
- DE
- Germany
- Prior art keywords
- diacyl
- antiinflammatory
- analgesic
- oxindole compounds
- oxindole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000202 analgesic effect Effects 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65237284A | 1984-09-19 | 1984-09-19 | |
| US06/747,194 US4690943A (en) | 1984-09-19 | 1985-06-20 | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3570078D1 true DE3570078D1 (en) | 1989-06-15 |
Family
ID=27096283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585306479T Expired DE3570078D1 (en) | 1984-09-19 | 1985-09-12 | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
Country Status (10)
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3568776D1 (en) * | 1984-02-07 | 1989-04-20 | Pfizer | 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents |
| US4652658A (en) * | 1984-03-19 | 1987-03-24 | Pfizer Inc. | Process for making 2-oxindole-1-carboxamides and intermediates therefor |
| US4808601A (en) * | 1984-09-19 | 1989-02-28 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
| US4752609A (en) * | 1985-06-20 | 1988-06-21 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
| ATE67185T1 (de) * | 1985-07-09 | 1991-09-15 | Pfizer | Substituierte oxindol-3-carboxamine als entzuendungshemmendes und schmerzstillendes mittel. |
| DK288287A (da) * | 1986-06-09 | 1987-12-10 | Pfizer | Heterocycliske forbindelser samt farmaceutiske praeparater til behandling af allergiske eller inflammatoriske tilstande |
| GB8623819D0 (en) * | 1986-10-03 | 1986-11-05 | Glaxo Group Ltd | Heterocyclic compounds |
| GB8720693D0 (en) * | 1987-09-03 | 1987-10-07 | Glaxo Group Ltd | Chemical compounds |
| WO1990008145A1 (en) * | 1989-01-10 | 1990-07-26 | Pfizer Inc. | Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles |
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
| US5300655A (en) * | 1989-04-18 | 1994-04-05 | Pfizer Inc. | 2-carboxy-thiophene derivatives |
| US5359068A (en) * | 1993-06-28 | 1994-10-25 | Pfizer Inc. | Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one |
| US6469181B1 (en) * | 1995-01-30 | 2002-10-22 | Catalytica, Inc. | Process for preparing 2-oxindoles and N-hydroxy-2-oxindoles |
| JP2004529110A (ja) | 2001-03-06 | 2004-09-24 | アストラゼネカ アクチボラグ | 脈管損傷活性を有するインドール誘導体 |
| AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
| MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| AR056317A1 (es) * | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
| MX2009003876A (es) | 2006-10-12 | 2009-05-11 | Xenon Pharmaceuticals Inc | Uso de compuestos de espiro-oxindol como agentes terapeuticos. |
| CN103664973B (zh) | 2008-10-17 | 2017-04-19 | 泽农医药公司 | 螺羟吲哚化合物及其作为治疗剂的用途 |
| EP2350091B1 (en) | 2008-10-17 | 2015-06-03 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| EP2246326A1 (de) | 2009-05-02 | 2010-11-03 | Bayer CropScience AG | Verfahren zur Herstellung von Oxindolen und ortho-substituierten Anilinen und ihre Verwendung als Zwischenprodukte für Synthesen |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| WO2011047174A1 (en) | 2009-10-14 | 2011-04-21 | Xenon Pharmaceuticals Inc. | Synthetic methods for spiro-oxindole compounds |
| RU2596488C2 (ru) | 2010-02-26 | 2016-09-10 | Ксенон Фармасьютикалз Инк. | Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов |
| WO2012028162A1 (de) | 2010-09-01 | 2012-03-08 | Bayer Cropscience Ag | Verfahren zur herstellung von oxindolen und ortho-substituierten anilinen und ihre verwendung als zwischenprodukte für synthesen |
| US9682033B2 (en) | 2015-02-05 | 2017-06-20 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
| CN104744338A (zh) * | 2015-03-31 | 2015-07-01 | 天津维智精细化工有限公司 | 一种6-氯羟吲哚的合成方法 |
| US10537552B2 (en) | 2015-05-05 | 2020-01-21 | Carafe Drug Innovation, Llc | Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3189617A (en) * | 1961-02-03 | 1965-06-15 | Sterling Drug Inc | 1-aryloxindoles and their preparation |
| GB1089071A (en) * | 1964-02-28 | 1967-11-01 | Merck & Co Inc | Indole derivatives |
| AT259553B (de) * | 1966-03-04 | 1968-01-25 | Italiana Sint Spa | Verfahren zur Herstellung von Indolderivaten |
| US3462450A (en) * | 1966-06-29 | 1969-08-19 | Merck & Co Inc | Chemical compounds |
| GB1158532A (en) * | 1967-01-05 | 1969-07-16 | Centre Nat Rech Scient | 2-Oxoindoline-3-Carboxylic Acids and Esters thereof |
| US3631177A (en) * | 1967-04-18 | 1971-12-28 | Smith Kline French Lab | 3-phenacyl-2-oxoindolines |
| US3519592A (en) * | 1967-04-18 | 1970-07-07 | Smithkline Corp | Indole compounds |
| BE714717A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1967-05-12 | 1968-09-30 | ||
| FR7337M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1968-01-11 | 1969-10-13 | ||
| BE756447A (fr) * | 1969-10-15 | 1971-03-22 | Pfizer | Oxindolecarboxamides |
| US3767653A (en) * | 1971-06-28 | 1973-10-23 | Squibb & Sons Inc | Thiazines |
| US3749731A (en) * | 1971-07-08 | 1973-07-31 | Warner Lambert Co | 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide |
| GB1436771A (en) * | 1973-02-16 | 1976-05-26 | Labaz | Indole derivatives and process for preparing the same |
| US3975531A (en) * | 1973-10-02 | 1976-08-17 | A. H. Robins Company, Incorporated | 4-(5- And 7-)benzoylindolin-2-ones and pharmaceutical uses thereof |
| US4221716A (en) * | 1979-02-16 | 1980-09-09 | A. H. Robins Company, Inc. | Intermediate and process for the preparation of 7-acylindolin-2-ones |
| DE3300522A1 (de) * | 1982-01-21 | 1983-07-28 | Sandoz-Patent-GmbH, 7850 Lörrach | 3,3-dialkyl- und 3,3-alkylen-indolinderivate, verfahren zu ihrer herstellung und pharmazeutische praeparate sie enthaltend |
-
1985
- 1985-06-20 US US06/747,194 patent/US4690943A/en not_active Expired - Lifetime
- 1985-09-12 EP EP85306479A patent/EP0175551B1/en not_active Expired
- 1985-09-12 DE DE8585306479T patent/DE3570078D1/de not_active Expired
- 1985-09-16 GR GR852244A patent/GR852244B/el unknown
- 1985-09-17 IE IE229785A patent/IE58140B1/en not_active IP Right Cessation
- 1985-09-17 CA CA000490913A patent/CA1256104A/en not_active Expired
- 1985-09-18 AU AU47561/85A patent/AU556948B2/en not_active Ceased
- 1985-09-18 IL IL76405A patent/IL76405A/xx not_active IP Right Cessation
- 1985-09-18 DK DK422485A patent/DK162443C/da not_active IP Right Cessation
- 1985-09-19 PH PH32810A patent/PH21580A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL76405A0 (en) | 1986-01-31 |
| IE58140B1 (en) | 1993-07-14 |
| DK162443B (da) | 1991-10-28 |
| DK422485A (da) | 1986-03-20 |
| AU556948B2 (en) | 1986-11-27 |
| CA1256104A (en) | 1989-06-20 |
| DK162443C (da) | 1992-03-23 |
| EP0175551A1 (en) | 1986-03-26 |
| GR852244B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1986-01-17 |
| DK422485D0 (da) | 1985-09-18 |
| IL76405A (en) | 1990-03-19 |
| EP0175551B1 (en) | 1989-05-10 |
| IE852297L (en) | 1986-03-19 |
| AU4756185A (en) | 1986-04-10 |
| PH21580A (en) | 1987-12-11 |
| US4690943A (en) | 1987-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |