DE3560141D1 - Ûalpha-(alkylaminomethyl)-benzylthio¨-acetic-acid derivatives, process for their preparation and their therapeutic use - Google Patents
Ûalpha-(alkylaminomethyl)-benzylthio¨-acetic-acid derivatives, process for their preparation and their therapeutic useInfo
- Publication number
- DE3560141D1 DE3560141D1 DE8585400431T DE3560141T DE3560141D1 DE 3560141 D1 DE3560141 D1 DE 3560141D1 DE 8585400431 T DE8585400431 T DE 8585400431T DE 3560141 T DE3560141 T DE 3560141T DE 3560141 D1 DE3560141 D1 DE 3560141D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- benzylthio
- alkyl
- alkylaminomethyl
- see diagramm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- -1 amine derivative of (benzylthio)acetic acid Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 229940071127 thioglycolate Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
Landscapes
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8404543A FR2561646B1 (fr) | 1984-03-23 | 1984-03-23 | Derives d'acide (a-(alkylaminomethyl)-benzyl)-thioacetique, procede de preparation et utilisation en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3560141D1 true DE3560141D1 (en) | 1987-05-27 |
Family
ID=9302390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8585400431T Expired DE3560141D1 (en) | 1984-03-23 | 1985-03-06 | Ûalpha-(alkylaminomethyl)-benzylthio¨-acetic-acid derivatives, process for their preparation and their therapeutic use |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0158545B1 (de) |
AT (1) | ATE26703T1 (de) |
DE (1) | DE3560141D1 (de) |
FR (1) | FR2561646B1 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2648814B1 (fr) * | 1989-06-26 | 1991-10-18 | Lafon Labor | L'alpha (tert-butyl-aminomethyl-3,4-dichlorobenzyl)thioacetamide, son procede de preparation et son application en therapeutique |
FR2734264B1 (fr) * | 1995-05-19 | 1997-08-01 | Lafon Labor | Utilisation de derives d'alpha-aminomethyl-3,4-dichlorobenzyl-thioacetamide pour la fabrication d'un medicament inhibant la recapture de la dopamine et nouveaux composes pour cette utilisation |
CA2282656A1 (en) * | 1997-02-27 | 1998-09-03 | American Cyanamid Company | N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
US6172057B1 (en) | 1997-02-27 | 2001-01-09 | American Cyanamid Company | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1520812A (en) * | 1975-10-02 | 1978-08-09 | Lafon Labor | Benzhydrylsulphinyl derivatives |
GB1584462A (en) * | 1977-03-31 | 1981-02-11 | Lafon Labor | N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them |
-
1984
- 1984-03-23 FR FR8404543A patent/FR2561646B1/fr not_active Expired
-
1985
- 1985-03-06 AT AT85400431T patent/ATE26703T1/de not_active IP Right Cessation
- 1985-03-06 EP EP85400431A patent/EP0158545B1/de not_active Expired
- 1985-03-06 DE DE8585400431T patent/DE3560141D1/de not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0158545B1 (de) | 1987-04-22 |
FR2561646B1 (fr) | 1987-10-09 |
FR2561646A1 (fr) | 1985-09-27 |
ATE26703T1 (de) | 1987-05-15 |
EP0158545A1 (de) | 1985-10-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |