DE3482261D1 - Ein-topfverfahren fuer herstellung von 7 beta-amino- und 7 beta-acylamino-3-substituierte methyl-3-cephem-4-carboxylsaeure-verbindungen und verfahren zur deoxygenation von 7 beta-acylamino-3-cephem-4-carboxylsaeure-1-oxyd-verbindungen. - Google Patents

Ein-topfverfahren fuer herstellung von 7 beta-amino- und 7 beta-acylamino-3-substituierte methyl-3-cephem-4-carboxylsaeure-verbindungen und verfahren zur deoxygenation von 7 beta-acylamino-3-cephem-4-carboxylsaeure-1-oxyd-verbindungen.

Info

Publication number
DE3482261D1
DE3482261D1 DE8484201215T DE3482261T DE3482261D1 DE 3482261 D1 DE3482261 D1 DE 3482261D1 DE 8484201215 T DE8484201215 T DE 8484201215T DE 3482261 T DE3482261 T DE 3482261T DE 3482261 D1 DE3482261 D1 DE 3482261D1
Authority
DE
Germany
Prior art keywords
beta
acylamino
ceylamino
oxyd
cephem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8484201215T
Other languages
English (en)
Inventor
Jan Verweij
Herman Hendrik Grootveld
Henri Gerard Julius Hirs
Veen Gerardus Johannes Van
Jan Kalter
Peter Wolfgang Henniger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Application granted granted Critical
Publication of DE3482261D1 publication Critical patent/DE3482261D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
DE8484201215T 1983-10-07 1984-08-24 Ein-topfverfahren fuer herstellung von 7 beta-amino- und 7 beta-acylamino-3-substituierte methyl-3-cephem-4-carboxylsaeure-verbindungen und verfahren zur deoxygenation von 7 beta-acylamino-3-cephem-4-carboxylsaeure-1-oxyd-verbindungen. Expired - Fee Related DE3482261D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP83201452 1983-10-07

Publications (1)

Publication Number Publication Date
DE3482261D1 true DE3482261D1 (de) 1990-06-21

Family

ID=8190997

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484201215T Expired - Fee Related DE3482261D1 (de) 1983-10-07 1984-08-24 Ein-topfverfahren fuer herstellung von 7 beta-amino- und 7 beta-acylamino-3-substituierte methyl-3-cephem-4-carboxylsaeure-verbindungen und verfahren zur deoxygenation von 7 beta-acylamino-3-cephem-4-carboxylsaeure-1-oxyd-verbindungen.

Country Status (14)

Country Link
US (1) US4695627A (de)
EP (1) EP0137534B1 (de)
JP (1) JPH06102666B2 (de)
AU (1) AU566944B2 (de)
CA (1) CA1268171C (de)
DE (1) DE3482261D1 (de)
DK (1) DK478184A (de)
ES (4) ES8609341A1 (de)
FI (1) FI83223C (de)
GR (1) GR80547B (de)
HU (1) HU195823B (de)
IL (1) IL72498A (de)
NO (1) NO168248C (de)
PT (1) PT79086B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2580652B1 (fr) * 1985-04-22 1989-01-06 Bristol Myers Co Acide 7-amino-3-propenylcephalosporanique et ses esters
EP0300546B1 (de) * 1987-07-10 1995-08-09 Gist-Brocades N.V. Cephalosporinderivate und Verfahren zur Herstellung von Cephem-Verbindungen
IL86941A (en) * 1987-07-10 1993-07-08 Gist Brocades Nv Process for the preparation of cephem compounds and some new cephalosporin derivatives prepared by this process
US5442058A (en) * 1989-10-16 1995-08-15 Akzo Nobel N.V. Conversion of penicillins and cephalosporins to 1-(S)-sulfoxides
US5159071A (en) * 1990-09-06 1992-10-27 Ranbaxy Laboratories Limited Process for the manufacture of 7-amino-3-exomethylene-3-cepham-4-carboxylic acid ester
US5604222A (en) * 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en) * 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
IT1273605B (it) * 1995-04-21 1997-07-08 Acs Dobfar Spa Processo di riduzione selettiva dei solfossidi di cefalosporine
AU2007337082A1 (en) * 2006-12-21 2008-07-03 Macrogenics Inc. Methods for the treatment of LADA and other adult-onset autoimmune diabetes using immunosuppressive monoclonal antibodies with reduced toxicity

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641014A (en) * 1968-10-03 1972-02-08 Lilly Co Eli Reduction of delta**3-cephalosporin sulfoxides
US4308380A (en) * 1973-03-15 1981-12-29 Fujisawa Pharmaceutical Co., Ltd. 2-Lower alkyl-2 or 3-cephem-4-carboxylic acid derivatives
JPS5826355B2 (ja) * 1974-07-24 1983-06-02 ザイダンホウジン サンギヨウカガクケンキユウキヨウカイ ７− アミノセフアロスポランサンユウドウタイノ セイゾウホウホウ
US4044022A (en) * 1974-11-29 1977-08-23 Hoffmann-La Roche Inc. 15-Oxasteroids
US4044002A (en) * 1976-06-09 1977-08-23 Eli Lilly And Company Reduction process for cephalosporin sulfoxides
JPS54112891A (en) * 1978-02-21 1979-09-04 Sangyo Kagaku Kenkyu Kyokai Preparation of 7-substituted aminocephalosporanic acid derivative
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
US4223133A (en) * 1979-02-01 1980-09-16 Eli Lilly And Company Cephalosporin reduction process
GB2069482B (en) * 1980-02-14 1984-04-04 Gist Brocades Nv Process for the preparation of 3'-bromosubstituted deacetoxycephalosporanic acid sulphoxide derivatives
US4266049A (en) * 1980-02-20 1981-05-05 Eli Lilly And Company Process for 3-iodomethyl cephalosporins

Also Published As

Publication number Publication date
ES8800239A1 (es) 1987-11-01
IL72498A0 (en) 1984-11-30
HU195823B (en) 1988-07-28
PT79086A (en) 1984-09-01
ES8800685A1 (es) 1987-11-16
ES8609341A1 (es) 1986-07-16
CA1268171A (en) 1990-04-24
DK478184D0 (da) 1984-10-05
DK478184A (da) 1985-04-08
EP0137534B1 (de) 1990-05-16
FI83223C (fi) 1991-06-10
ES553559A0 (es) 1987-11-01
PT79086B (en) 1986-08-14
AU3091384A (en) 1985-07-04
EP0137534A3 (en) 1986-01-08
CA1268171C (en) 1990-04-24
NO168248C (no) 1992-01-29
JPH06102666B2 (ja) 1994-12-14
IL72498A (en) 1988-12-30
AU566944B2 (en) 1987-11-05
NO843283L (no) 1985-04-09
ES8800238A1 (es) 1987-11-01
FI843926A0 (fi) 1984-10-05
FI83223B (fi) 1991-02-28
HUT37151A (en) 1985-11-28
NO168248B (no) 1991-10-21
US4695627A (en) 1987-09-22
ES536576A0 (es) 1986-07-16
EP0137534A2 (de) 1985-04-17
ES553557A0 (es) 1987-11-01
ES553558A0 (es) 1987-11-16
FI843926L (fi) 1985-04-08
JPS60100584A (ja) 1985-06-04
GR80547B (en) 1985-02-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee