DE3479662D1 - Novel preparation of nucleoside phosphoramidite intermediates - Google Patents

Novel preparation of nucleoside phosphoramidite intermediates

Info

Publication number
DE3479662D1
DE3479662D1 DE8484902180T DE3479662T DE3479662D1 DE 3479662 D1 DE3479662 D1 DE 3479662D1 DE 8484902180 T DE8484902180 T DE 8484902180T DE 3479662 T DE3479662 T DE 3479662T DE 3479662 D1 DE3479662 D1 DE 3479662D1
Authority
DE
Germany
Prior art keywords
novel preparation
nucleoside phosphoramidite
phosphoramidite intermediates
intermediates
nucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484902180T
Other languages
English (en)
Inventor
Serge Beaucage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Instruments Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Instruments Inc filed Critical Beckman Instruments Inc
Application granted granted Critical
Publication of DE3479662D1 publication Critical patent/DE3479662D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
DE8484902180T 1983-06-01 1984-05-14 Novel preparation of nucleoside phosphoramidite intermediates Expired DE3479662D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50010383A 1983-06-01 1983-06-01
PCT/US1984/000743 WO1984004749A1 (en) 1983-06-01 1984-05-14 Novel preparation of nucleoside phosphoramidite intermediates

Publications (1)

Publication Number Publication Date
DE3479662D1 true DE3479662D1 (en) 1989-10-12

Family

ID=23988045

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484902180T Expired DE3479662D1 (en) 1983-06-01 1984-05-14 Novel preparation of nucleoside phosphoramidite intermediates

Country Status (4)

Country Link
EP (1) EP0144386B1 (de)
JP (1) JPS60500817A (de)
DE (1) DE3479662D1 (de)
WO (1) WO1984004749A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071974A (en) * 1986-10-31 1991-12-10 Amoco Corporation Compositions and methods for the synthesis of oligonucleotides having 5'-phosphorylated termini
EP0863910A1 (de) 1995-10-19 1998-09-16 NeXstar Pharmaceuticals, Inc. Verfahren zur herstellung von oligonucleotiden in lösungen
ES2212097T3 (es) * 1996-05-03 2004-07-16 Avecia Biotechnology Inc Preparacion in situ de fosforamiditos de nucleosidos y su uso en sintesis de oligonucleotidos.
CA2561741C (en) 2004-04-05 2016-09-27 Alnylam Pharmaceuticals, Inc. Processes and reagents for oligonucleotide synthesis and purification
CN101611048B (zh) 2006-12-12 2012-11-07 赛托斯生物技术公司 含有高浓度鸟嘌呤单体的寡核苷酸

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
EP0090789A1 (de) * 1982-03-26 1983-10-05 Monsanto Company Chemische DNA-Synthese

Also Published As

Publication number Publication date
EP0144386A1 (de) 1985-06-19
JPS6330317B2 (de) 1988-06-17
JPS60500817A (ja) 1985-05-30
EP0144386B1 (de) 1989-09-06
WO1984004749A1 (en) 1984-12-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee