DE3475065D1 - (acyloxyalkoxy) carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs, their preparation and pharmaceutical compositions containing said derivatives - Google Patents
(acyloxyalkoxy) carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs, their preparation and pharmaceutical compositions containing said derivativesInfo
- Publication number
- DE3475065D1 DE3475065D1 DE8484401270T DE3475065T DE3475065D1 DE 3475065 D1 DE3475065 D1 DE 3475065D1 DE 8484401270 T DE8484401270 T DE 8484401270T DE 3475065 T DE3475065 T DE 3475065T DE 3475065 D1 DE3475065 D1 DE 3475065D1
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- acyloxyalkoxy
- drugs
- primary
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50731683A | 1983-06-23 | 1983-06-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3475065D1 true DE3475065D1 (en) | 1988-12-15 |
Family
ID=24018147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8484401270T Expired DE3475065D1 (en) | 1983-06-23 | 1984-06-20 | (acyloxyalkoxy) carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs, their preparation and pharmaceutical compositions containing said derivatives |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0130119B1 (de) |
JP (1) | JP2505728B2 (de) |
CA (1) | CA1330995C (de) |
DE (1) | DE3475065D1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2258217C (en) | 1996-06-14 | 2005-08-09 | Biocryst Pharmaceuticals Inc. | Substituted cyclopentane compounds useful as neuraminidase inhibitors |
US6562861B1 (en) | 1997-12-17 | 2003-05-13 | Biocryst Pharmaceuticals, Inc. | Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
AU7675798A (en) * | 1998-04-09 | 1999-11-01 | Meiji Seika Kaisha Ltd. | Nitrogen-containing heterocyclic compounds having antiplatelet aggregation effect and medicinal use thereof |
US6258800B1 (en) * | 1998-04-15 | 2001-07-10 | Warner-Lambert Company | Prodrugs of benzofuranylethyl carbamate NK1 antagonists |
AU1520300A (en) | 1998-11-05 | 2000-05-29 | Biocryst Pharmaceuticals, Inc. | New cyclopentane and cyclopentene compounds and use for detecting influenza virus |
CN1361766A (zh) | 1999-07-19 | 2002-07-31 | 盐野义制药株式会社 | 具有酰氧基甲氧基羰基侧链的三环化合物 |
US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
EP1902714B1 (de) * | 2001-06-11 | 2012-01-11 | XenoPort, Inc. | Prodrugs aus GABA-Analoga, Zusammensetzungen und ihre Verwendungen |
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US7109239B2 (en) | 2003-08-20 | 2006-09-19 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
EP2354120A1 (de) * | 2003-08-20 | 2011-08-10 | XenoPort, Inc. | Synthese von Acyloxyalkylcarbamat-Prodrugs und Zwischenprodukten davon |
ATE546427T1 (de) * | 2003-08-20 | 2012-03-15 | Xenoport Inc | Acyloxyalkylcarbamat-prodrugs, syntheseverfahren und anwendung |
AU2007332904A1 (en) * | 2006-12-08 | 2008-06-19 | Xenoport, Inc. | Use of prodrugs of GABA analogs for treating diseases |
FR2931151A1 (fr) * | 2008-05-13 | 2009-11-20 | Pharmaleads Soc Par Actions Si | Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique |
CA2740087C (en) | 2008-10-08 | 2019-07-23 | Kyphia Pharmaceuticals, Inc. | Gaba conjugates and methods of use thereof |
CA2906689A1 (en) | 2013-03-15 | 2014-09-18 | Kala Pharmaceuticals, Inc. | Meropenem derivatives and uses thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4011217A (en) * | 1973-04-19 | 1977-03-08 | Merck Sharp & Dohme (I.A.) Corporation | 4-(3-amino-2-acyloxypropoxy)-1,2,5-thiadiazole compounds |
US4426391A (en) * | 1982-09-15 | 1984-01-17 | Merck & Co., Inc. | [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa |
-
1984
- 1984-06-20 EP EP84401270A patent/EP0130119B1/de not_active Expired
- 1984-06-20 DE DE8484401270T patent/DE3475065D1/de not_active Expired
- 1984-06-21 CA CA000457139A patent/CA1330995C/en not_active Expired - Fee Related
- 1984-06-22 JP JP59127732A patent/JP2505728B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2505728B2 (ja) | 1996-06-12 |
CA1330995C (en) | 1994-07-26 |
JPS6023359A (ja) | 1985-02-05 |
EP0130119A3 (en) | 1985-09-25 |
EP0130119A2 (de) | 1985-01-02 |
EP0130119B1 (de) | 1988-11-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |