DE3466874D1 - A method for splitting di-sulphide bonds - Google Patents

A method for splitting di-sulphide bonds

Info

Publication number
DE3466874D1
DE3466874D1 DE8484850153T DE3466874T DE3466874D1 DE 3466874 D1 DE3466874 D1 DE 3466874D1 DE 8484850153 T DE8484850153 T DE 8484850153T DE 3466874 T DE3466874 T DE 3466874T DE 3466874 D1 DE3466874 D1 DE 3466874D1
Authority
DE
Germany
Prior art keywords
splitting
compound
organic
bond
carbon atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484850153T
Other languages
German (de)
English (en)
Inventor
Rolf Erik Axel Verner Axen
Jan Per Erik Carlsson
Hakan Nils Yngve Drevin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phadia AB
Original Assignee
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia AB filed Critical Pharmacia AB
Application granted granted Critical
Publication of DE3466874D1 publication Critical patent/DE3466874D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/122—Hydrolysis with acids different from HF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B45/00—Formation or introduction of functional groups containing sulfur
    • C07B45/06—Formation or introduction of functional groups containing sulfur of mercapto or sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/809—Drug, bio-affecting and body treating compositions involving immunoglobulin or antibody fragment, e.g. fab', fv, fc, heavy chain or light chain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/862—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgE or IgD
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8484850153T 1983-05-17 1984-05-16 A method for splitting di-sulphide bonds Expired DE3466874D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8302758A SE8302758L (sv) 1983-05-17 1983-05-17 Sett for uppspjelkning av disulfidbindningar och derigenom erhallen forening

Publications (1)

Publication Number Publication Date
DE3466874D1 true DE3466874D1 (en) 1987-11-26

Family

ID=20351202

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484850153T Expired DE3466874D1 (en) 1983-05-17 1984-05-16 A method for splitting di-sulphide bonds

Country Status (7)

Country Link
US (1) US4647655A (OSRAM)
EP (1) EP0128885B1 (OSRAM)
JP (1) JPS60501310A (OSRAM)
AT (1) ATE30314T1 (OSRAM)
DE (1) DE3466874D1 (OSRAM)
SE (1) SE8302758L (OSRAM)
WO (1) WO1984004525A1 (OSRAM)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879249A (en) * 1983-02-25 1989-11-07 Baldwin Thomas O Linker compounds, linker-compound-ligands and linker-compound-receptors
DE3440988A1 (de) * 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
US4698420A (en) * 1985-02-25 1987-10-06 Xoma Corporation Antibody hybrid molecules and process for their preparation
US5283323A (en) * 1985-08-07 1994-02-01 The United States Of America As Represented By The Department Of Health And Human Services Method of producing immune response
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
US5239062A (en) * 1986-03-20 1993-08-24 Dana-Farber Cancer Institute, Inc. Blocked lectins, methods and affinity support for making same using affinity ligands, and method of killing selected cell populations having reduced nonselective cytotoxicity
US5395924A (en) * 1986-03-20 1995-03-07 Dana-Farber Cancer Institute, Inc. Blocked lectins; methods and affinity support for making the same using affinity ligands; and method of killing selected cell populations having reduced non-selective cytotoxicity
US4794082A (en) * 1987-02-17 1988-12-27 Hoechst Celanese Corporation Biotinylating agents
DE3809986A1 (de) * 1988-03-24 1989-10-05 Boehringer Mannheim Gmbh Verbindungen zur einfuehrung einer sh-gruppe in tyrosin
US5612016A (en) * 1988-04-01 1997-03-18 Immunomedics, Inc. Conjugates of antibodies and bifunctional ligands
US5137877B1 (en) * 1990-05-14 1996-01-30 Bristol Myers Squibb Co Bifunctional linking compounds conjugates and methods for their production
US5378813A (en) * 1992-05-29 1995-01-03 President And Fellows Of Harvard College Meso-2,5-dimercapto-N,N,N'N'-tetramethyladipamide
FR2710340B1 (fr) * 1993-09-22 1995-12-15 D Hinterland Lucien Dussourd Dérivés peptidiques de l'alpha-MSH et leur application .
SE9700769D0 (sv) 1997-03-04 1997-03-04 Pharmacia Biotech Ab Matriser för separation och separation som utnyttjar matriserna
US6801270B2 (en) * 2000-06-26 2004-10-05 Reveo, Inc. Backlight for a liquid crystal display having high light-recycling efficiency
WO2002030542A2 (en) * 2000-10-12 2002-04-18 Robert Corcoran Purification of substance by reaction affinity chromatography

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE431758B (sv) * 1977-03-04 1984-02-27 Pharmacia Fine Chemicals Ab Som tioleringsreagens eller berarmatris for enzymer anvendbart derivat av en sh-grupphaltig polymer
SE427505B (sv) * 1977-03-04 1983-04-11 Pharmacia Diagnostics Ab Reagens till anvendning vid immunkemiska bestemningsmetoder
SE430062B (sv) * 1977-03-04 1983-10-17 Pharmacia Fine Chemicals Ab Kopplings- eller tioleringsreagens
SE448631B (sv) * 1978-04-28 1987-03-09 Toyo Jozo Kk Disulfidforening av en berare med s-s-utbytesreaktivitet
US4258193A (en) * 1978-07-13 1981-03-24 Toyo Jozo Kabushiki Kaisha Disulfide derivatives having S--S exchange reactivity
SE8102193L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och dess anvendning
SE8102194L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
US4511501A (en) * 1982-09-13 1985-04-16 Board Of Regents, The University Of Texas System Bis-amide disulfide cleavable cross-linking reagents

Also Published As

Publication number Publication date
JPS60501310A (ja) 1985-08-15
SE8302758L (sv) 1984-11-18
US4647655A (en) 1987-03-03
WO1984004525A1 (en) 1984-11-22
EP0128885B1 (en) 1987-10-21
EP0128885A1 (en) 1984-12-19
JPH0561279B2 (OSRAM) 1993-09-06
ATE30314T1 (de) 1987-11-15
SE8302758D0 (sv) 1983-05-17

Similar Documents

Publication Publication Date Title
SE8302758L (sv) Sett for uppspjelkning av disulfidbindningar och derigenom erhallen forening
ATE54303T1 (de) Verfahren zur reduktiven dehalogenierung von organischen halogenverbindungen.
ATE65519T1 (de) In wasser dispergierbare kunstharze, verfahren zur herstellung der kunstharze und verwendung der kunstharze als bindemittel fuer electrotauchlackbaeder.
PL222392A1 (OSRAM)
BG43867A3 (en) Method for preparing of 6- alpha- methylcorticoids
FR2604715B1 (fr) Procede de fabrication de revetements par radioreticulation
DE3569390D1 (en) Alpha-hydroxyketone as an antiskinning agent
DE69106386D1 (en) Oxysulfonylcarbamate.
ATE60058T1 (de) Einstufiges verfahren zur herstellung von gemischt substituierten 1,2-di-acyl-sn-glycero-3- phosphocholinen.
GB1080717A (en) Purification of crude organic polyisocyanates
KR830010083A (ko) 치환된 아세트 아닐리드 유도체의 제조방법
ATE3426T1 (de) Verfahren zur herstellung von oxiranen.
CA1260003C (OSRAM)
HUT48566A (en) Process for production of dien-1-ols
Isola et al. Pummerer-like reaction of sulphinamides
DE3462881D1 (en) Process for the preparation of 2,2,2 trifluoroethanol
EP0236984A3 (en) Syndet soap
DE3863518D1 (de) Verfahren zur herstellung von feuchtigkeitshaertenden bindemittelkombinationen, die nach diesem verfahren erhaeltlichen kombinationen und ihre verwendung.
ES8300113A1 (es) Un procedimiento para preparar compuestos de cefem .
ES8302005A1 (es) Procedimiento para preparar compuestos cefalosporanicos
ES2034252T3 (es) Procedimiento para la preparacion de compuestos macrolidos.
KR920000819A (ko) 신규한 에폭시수지 변성체와 그 제조방법
EP0035214A3 (de) Verfahren zur Herstellung heterocyclischer Thioverbindungen
ES8301916A1 (es) Procedimiento de obtencion de derivados del (2-oxo-pirroli- dina-1)-y del (2-oxo-piperidina-1)-acido carboxilico (acido organico)
ATE19774T1 (de) Verfahren zur herstellung von 1-(4-chlorbenzoyl)5-methoxy-2-methyl-3-indolacetoxyessigs|ure.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA & UPJOHN DIAGNOSTICS AB, UPPSALA, SE