DE3466693D1 - Liquid-phase synthesis of hpgrf (somatocrinin) and intermediate peptides - Google Patents

Liquid-phase synthesis of hpgrf (somatocrinin) and intermediate peptides

Info

Publication number
DE3466693D1
DE3466693D1 DE8484400343T DE3466693T DE3466693D1 DE 3466693 D1 DE3466693 D1 DE 3466693D1 DE 8484400343 T DE8484400343 T DE 8484400343T DE 3466693 T DE3466693 T DE 3466693T DE 3466693 D1 DE3466693 D1 DE 3466693D1
Authority
DE
Germany
Prior art keywords
hpgrf
somatocrinin
liquid
phase synthesis
intermediate peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484400343T
Other languages
English (en)
Inventor
J Diaz
Henri Demarne
Romeo Roncucci
Paul-Henry Schmelck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8302781A external-priority patent/FR2541271B1/fr
Priority claimed from FR8319058A external-priority patent/FR2555588B1/fr
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of DE3466693D1 publication Critical patent/DE3466693D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069—Ser-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8484400343T 1983-02-21 1984-02-20 Liquid-phase synthesis of hpgrf (somatocrinin) and intermediate peptides Expired DE3466693D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8302781A FR2541271B1 (fr) 1983-02-21 1983-02-21 Nouvelle synthese du hpgrf en phase liquide
FR8319058A FR2555588B1 (fr) 1983-11-29 1983-11-29 Procede de synthese en phase liquide de la somatocrinine et peptides intermediaires

Publications (1)

Publication Number Publication Date
DE3466693D1 true DE3466693D1 (en) 1987-11-12

Family

ID=26223300

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484400343T Expired DE3466693D1 (en) 1983-02-21 1984-02-20 Liquid-phase synthesis of hpgrf (somatocrinin) and intermediate peptides

Country Status (10)

Country Link
US (1) US4581168A (de)
EP (1) EP0122818B1 (de)
KR (1) KR910006284B1 (de)
AU (1) AU574348B2 (de)
CA (1) CA1267998A (de)
DE (1) DE3466693D1 (de)
DK (1) DK79284A (de)
IE (1) IE56918B1 (de)
IL (1) IL71031A (de)
NZ (1) NZ207205A (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704450A (en) * 1983-02-21 1987-11-03 Sanofi Synthesis of hpGRF(Somatocrinin) in liquid phase and intermediate peptides
DE3327007A1 (de) * 1983-07-27 1985-02-07 Hoechst Ag, 6230 Frankfurt Herstellung von polypeptiden mit einem saeureamid-carboxyterminus
FR2567524B1 (fr) * 1984-07-10 1987-11-27 Sanofi Sa Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires
EP0193910A3 (de) * 1985-03-06 1988-11-23 Sumitomo Pharmaceuticals Company, Limited Synthese eines GRF-Derivats und peptidische Zwischenverbindungen
FR2599038B1 (fr) * 1986-05-26 1990-06-29 Sanofi Sa Procede de preparation de nonacosapeptides et peptides intermediaires
US5565606A (en) * 1986-10-21 1996-10-15 Hoechst Aktiengesellschaft Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
US5200526A (en) * 1987-04-27 1993-04-06 The Governors Of The University Of Alberta Syntheses of optically pure α-amino acids from 3-amino-2-oxetanone salts
US4888385A (en) * 1987-04-30 1989-12-19 Millipore Corporation BOP reagent for solid phase peptide synthesis
IT1226552B (it) * 1988-07-29 1991-01-24 Ellem Ind Farmaceutica Peptidi immunostimolanti.
DE69108192T2 (de) * 1990-12-10 1995-07-20 Hoffmann La Roche Verfahren zur enzymatischen Herstellung von GRF(1-44)NH2.
IE921942A1 (en) * 1992-06-16 1993-12-29 Gary A Siwruk John S Eynon Liquid phase synthesis of peptides and peptide derivatives
US5516891A (en) * 1992-06-16 1996-05-14 Kinerton, Ltd. Liquid phase synthesis of peptides and peptide derivatives
US6013764A (en) * 1996-07-17 2000-01-11 Ortho Pharmaceutical Corp. Liquid phase peptide synthesis of KL-4 pulmonary surfactant
KR200427009Y1 (ko) * 2006-07-06 2006-09-21 노승설 치약이 내장된 칫솔
JP6564539B1 (ja) 2018-09-14 2019-08-21 長瀬産業株式会社 スルホン酸化合物によるペプチド精製方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU466760B2 (en) * 1972-03-14 1975-11-06 Takeda Chemical Industries Ltd. Process for producing peptide
JPS5726506B2 (de) * 1974-03-08 1982-06-04
FR2451915A1 (fr) * 1979-03-23 1980-10-17 Clin Midy Nouveau procede de preparation de la somatostatine
DE2919592A1 (de) * 1979-05-15 1981-01-15 Max Planck Gesellschaft Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon
NZ204456A (en) * 1982-06-16 1987-05-29 Salk Inst For Biological Studi Synthetic pancreatic growth-hormone releasing factor
US4563352A (en) * 1982-10-04 1986-01-07 The Salk Institute For Biological Studies Human pancreatic GRF
US4476116A (en) * 1982-12-10 1984-10-09 Syntex (U.S.A.) Inc. Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
AU3318184A (en) * 1984-08-10 1986-03-07 Immunetech Pharmaceuticals Immunotherapeutic polypeptide agents

Also Published As

Publication number Publication date
EP0122818A1 (de) 1984-10-24
IE56918B1 (en) 1992-01-29
IE840387L (en) 1984-08-21
NZ207205A (en) 1988-04-29
AU2477484A (en) 1984-08-30
US4581168A (en) 1986-04-08
CA1267998A (en) 1990-04-17
KR910006284B1 (ko) 1991-08-19
EP0122818B1 (de) 1987-10-07
DK79284A (da) 1984-08-22
KR850000469A (ko) 1985-02-27
IL71031A (en) 1988-03-31
IL71031A0 (en) 1984-05-31
AU574348B2 (en) 1988-07-07
DK79284D0 (da) 1984-02-20

Similar Documents

Publication Publication Date Title
GB8317880D0 (en) Structure and synthesis of interferons
GB2140619B (en) Fabrication of fet's
GB8425710D0 (en) Modification of polypeptides
JPS6427497A (en) Human interleukin 2 like polypeptide
DE3466693D1 (en) Liquid-phase synthesis of hpgrf (somatocrinin) and intermediate peptides
NZ210767A (en) Preparation of alcohols from co and h 2
PL245687A1 (en) Method of obtaining peptides
DE3479314D1 (en) Substituted 2-aminotetralins and processes for synthesis
PT85548A (en) Synthesis and separation of peptides
PT79088A (en) The synthesis of cyclopropane amino acids and peptides
GB2159160B (en) Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
ZA868713B (en) Synthesis of aryloxypropanolamines and arylethanolamines
GB2140805B (en) Isolation of aspartame
EP0146384A3 (en) Synthesis of silicophosphoaluminate
EP0166520A3 (en) Metallophosphoaluminates and their synthesis
EP0131317A3 (en) Therapeutical use of bendazac
GB8417178D0 (en) Preparation of 3 3 3-trifluoro-2-trifluoromethylpropene
IL71812A0 (en) Synthesis of(+)-4-demethoxydaunomycinone and intermediates therefor
GB8717932D0 (en) Inhibitor of protein synthesis
DE3265905D1 (en) Dimers of peptide amides
GB8416629D0 (en) Preparation of 3 11-dimethyl-2-nonacosanone
ZA849728B (en) Synthesis of silicophosphoaluminate
GB8719341D0 (en) Inhibitor of protein synthesis
IE851699L (en) SYNTHESIS OF hGRF (STOMATOCRININ) AND INTERMEDIATE PEPTIDES
HUT39475A (en) Vectors of expression

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee