DE3460820D1 - Novel compounds and compositions useful for producing analgesia - Google Patents

Novel compounds and compositions useful for producing analgesia

Info

Publication number
DE3460820D1
DE3460820D1 DE8484304729T DE3460820T DE3460820D1 DE 3460820 D1 DE3460820 D1 DE 3460820D1 DE 8484304729 T DE8484304729 T DE 8484304729T DE 3460820 T DE3460820 T DE 3460820T DE 3460820 D1 DE3460820 D1 DE 3460820D1
Authority
DE
Germany
Prior art keywords
novel compounds
compositions useful
producing analgesia
analgesia
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484304729T
Other languages
German (de)
English (en)
Inventor
John Michael Janusz
Thomas Robert Lahann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of DE3460820D1 publication Critical patent/DE3460820D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8484304729T 1983-07-14 1984-07-11 Novel compounds and compositions useful for producing analgesia Expired DE3460820D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/514,204 US4532139A (en) 1983-07-14 1983-07-14 Compounds and compositions useful for producing analgesia

Publications (1)

Publication Number Publication Date
DE3460820D1 true DE3460820D1 (en) 1986-10-30

Family

ID=24046218

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484304729T Expired DE3460820D1 (en) 1983-07-14 1984-07-11 Novel compounds and compositions useful for producing analgesia

Country Status (15)

Country Link
US (1) US4532139A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0132114B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS6084251A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU566192B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1244049A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3460820D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK345884A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2144415B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK74990A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE57567B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY101021A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ208899A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH20512A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG45190G (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA845348B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493848A (en) * 1983-07-14 1985-01-15 The Procter & Gamble Company Compositions and methods useful for producing analgesia
US4681897A (en) * 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
DE3520761A1 (de) * 1984-06-11 1985-12-12 Ajinomoto Co., Inc., Tokio/Tokyo Verwendung von vanillylamin oder vanillylamiden zur foerderung des fettstoffwechsels
US5013759A (en) * 1985-06-10 1991-05-07 The Procter & Gamble Company Compounds and compositions having anti-inflammatory and analgesic activity
GB2178031B (en) 1985-06-10 1989-07-26 Procter & Gamble Phenylacetic acid amides having anti-inflammatory and analgesic activity
US4689182A (en) * 1985-12-20 1987-08-25 Warner-Lambert Company Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity
US4990533A (en) * 1985-12-20 1991-02-05 Warner-Lambert Co. Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity
US4980366A (en) * 1986-08-19 1990-12-25 Warner-Lambert Co. Amide, sulfonamide, urea, carbamate, thiocarbamate, and thiourea derivatives of 4'hydroxybenzylamine having anti-inflammatory and analgesic activity
US5045565A (en) * 1987-03-09 1991-09-03 The Procter & Gamble Company Novel compounds, pharmaceutical compositions, and methods for treating inflammation and pain
US5099030A (en) * 1987-03-09 1992-03-24 The Procter & Gamble Company Novel compounds, pharmaceutical compositions, and methods for treating inflammation and pain
US5461075A (en) * 1988-06-17 1995-10-24 The Procter & Gamble Company Use of vanilloids for the prevention of lesions due to herpes simplex infections
US5322862A (en) * 1990-05-22 1994-06-21 Nippon Kayaku Kabushiki Kaisha Resin molding composition for preventing gnawing damage by animals
US5762963A (en) * 1995-06-07 1998-06-09 Emory University Method and compositions for controlling oral and pharyngeal pain using capsaicinoids
US6248788B1 (en) 1996-11-06 2001-06-19 The Regents Of The University Of California Therapeutic method with capsaicin and capasicin analogs
US6239180B1 (en) 1995-11-08 2001-05-29 The Regents Of The University Of California Transdermal therapeutic device and method with capsaicin and capsaicin analogs
US6689399B1 (en) 2000-03-16 2004-02-10 James R. Dickson Transdermal delivery of an anti-inflammatory composition
AU2002254007B2 (en) 2001-02-22 2006-09-21 Purdue Research Foundation Compositions based on vanilloid-catechin synergies for prevention and treatment of cancer
US7192612B2 (en) * 2001-02-22 2007-03-20 Purdue Research Foundation Compositions and methods based on synergies between capsicum extracts and tea catechins for prevention and treatment of cancer
EP1414427A4 (en) * 2001-08-10 2004-08-18 Synta Pharmaceuticals Corp KAVALACTONE COMPOSITIONS AND METHODS OF USE
CA2464528A1 (en) * 2001-11-02 2003-05-15 Elan Corporation, Plc Pharmaceutical composition
US8623412B2 (en) * 2002-09-23 2014-01-07 Elan Pharma International Limited Abuse-resistant pharmaceutical compositions
CA2510181C (en) * 2002-12-18 2011-03-08 Algorx Pharmaceuticals, Inc. Administration of capsaicinoids
EP1610742B1 (en) 2003-04-10 2015-01-21 Neurogesx, Inc. Uses and compositions for administration of capsaicin
WO2006060505A2 (en) * 2004-12-01 2006-06-08 Dacanay Rhodel G Capsaicin nutritional supplement
ZA200707492B (en) * 2005-02-14 2009-02-25 Neurogesx Inc Device for delivery of TRPV1 agonists
CA2602832A1 (en) * 2005-03-30 2006-10-05 Keith R. Bley Low-concentration capsaicin patch and methods for treating neuropathic pain
US8158682B2 (en) * 2008-09-12 2012-04-17 Vallinex, Inc. Instillation administration of capsaicinoids for the treatment of pain
PL2629610T3 (pl) 2010-07-27 2018-02-28 Flex Pharma, Inc. Sposoby i kompozycje do zapobiegania i zmniejszania kurczy mięśni i do regeneracji po nerwowo-mięśniowym podrażnieniu i zmęczeniu po ćwiczeniach fizycznych
CN101973903A (zh) * 2010-10-12 2011-02-16 浙江大学 辣椒碱同系物的合成方法
EP2646107A2 (en) 2010-12-01 2013-10-09 Spinal Modulation Inc. Agent delivery systems for selective neuromodulation
CN110839775A (zh) 2015-10-09 2020-02-28 艾克西化学公司 包含合成辣椒素类衍生物的禽饲料以及这样的饲料用于沙门氏菌感染的预防性用途或治疗
US11253493B2 (en) 2017-01-23 2022-02-22 Cliff-Cartwright Corporation Compositions and methods affecting exercise performance
AU2018351640B2 (en) * 2017-10-20 2024-02-29 Axichem Ab Synthetic capsaicin analogues as bioenhancers

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3024281A (en) * 1962-03-06 Amidomethylation of aromatic
US2710299A (en) * 1950-10-21 1955-06-07 Thomae Gmbh Dr K Process for the production of crystalline vanillyl amides
DE938014C (de) * 1952-11-05 1956-01-19 Beiersdorf & Co A G P Verfahren zur Herstellung kristallisierter Vanillylamide
US2845449A (en) * 1956-07-11 1958-07-29 California Research Corp Thioamide production
NL269079A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1960-09-09 1964-06-25
US3108038A (en) * 1962-01-08 1963-10-22 Du Pont Anilide nematocides
US3192213A (en) * 1962-10-12 1965-06-29 Olin Mathieson Aminoalkyl anilides
US3167556A (en) * 1963-11-19 1965-01-26 Olin Mathieson Basic derivatives of anilides
SE353319B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1964-08-15 1973-01-29 Sumitomo Chemical Co
US3201401A (en) * 1964-09-17 1965-08-17 Olin Mathieson Aminoalkoxy and aminoalkylthioanilide compounds
GB1150051A (en) * 1966-03-11 1969-04-30 Science Union & Cie New Phenylisopropylamide Derivatives and Process for Preparing Them
US3780103A (en) * 1967-03-30 1973-12-18 Ciba Geigy Corp Alkylhydroxybenzylamides
US4031186A (en) * 1975-07-10 1977-06-21 Rohm And Haas Company Arylaminoalkylthioamides
DE2752366A1 (de) * 1977-11-24 1979-05-31 Bayer Ag 3,3-dimethyl-4-penten-thiosaeureamide und verfahren zu ihrer herstellung
US4244730A (en) * 1979-07-02 1981-01-13 Chevron Research Company Herbicidal N-haloacetyl-2-alkyl-6-acylanilines
US4372972A (en) * 1979-09-14 1983-02-08 Rohm And Haas Company N-Substituted alkynyl anilines

Also Published As

Publication number Publication date
JPH0472820B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-11-19
DK345884A (da) 1985-01-15
DK345884D0 (da) 1984-07-13
PH20512A (en) 1987-01-26
NZ208899A (en) 1988-03-30
JPS6084251A (ja) 1985-05-13
IE841814L (en) 1985-01-14
MY101021A (en) 1991-06-29
US4532139A (en) 1985-07-30
ZA845348B (en) 1985-03-27
SG45190G (en) 1990-08-17
AU3058684A (en) 1985-01-17
GB8417625D0 (en) 1984-08-15
CA1244049A (en) 1988-11-01
HK74990A (en) 1990-09-28
GB2144415B (en) 1987-11-25
IE57567B1 (en) 1992-12-16
EP0132114B1 (en) 1986-09-24
AU566192B2 (en) 1987-10-08
EP0132114A1 (en) 1985-01-23
GB2144415A (en) 1985-03-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee