DE3439716A1 - Novel use of somatostatin - Google Patents
Novel use of somatostatinInfo
- Publication number
- DE3439716A1 DE3439716A1 DE19843439716 DE3439716A DE3439716A1 DE 3439716 A1 DE3439716 A1 DE 3439716A1 DE 19843439716 DE19843439716 DE 19843439716 DE 3439716 A DE3439716 A DE 3439716A DE 3439716 A1 DE3439716 A1 DE 3439716A1
- Authority
- DE
- Germany
- Prior art keywords
- somatostatin
- intraspinal
- infusions
- analgesic
- intraventricular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Neue Verwendung von SomatostatinNew uses of somatostatin
Gegenstand der deutschen Patentanmeldung P 34 09 062.2 ist eine neue Verwendung von Somatostatin, nämlich in Form von periduralen Injektionen und Infusionen als Analgetikum.The subject of German patent application P 34 09 062.2 is a new one Use of somatostatin, namely in the form of peridural injections and infusions as an analgesic.
Es wurde jetzt gefunden, daß auch intraspinale und sogar intraventrikuläre Injektionen und Infusionen von Somatostatin beim Menschen zu einer ausgeprägten, dem Morphin vergleichbaren, analgetischen Wirkung führen.It has now been found that also intraspinal and even intraventricular Injections and infusions of somatostatin in humans at a pronounced, produce analgesic effects comparable to morphine.
Dazu wurden Krebspatienten mit unerträglichen Schmerzen im terminalen Stadium oder auch bei postoperativen Schmerzen 250 ßg Somatostatin als Injektion und danach 10 bis 50 ßg Somatostatin pro Stunde als Infusion teils intraspinal, teils intraventrikulär appliziert. Diese Behandlungen führten zu einer ausgeprägten Analgesie, die der des Morphins vergleichbar ist. Die Infusionen wurden länger als 2 Wochen nebenwirkungsfrei vertragen.These were cancer patients with excruciating pain in the terminal Stage or in the case of postoperative pain, 250 μg somatostatin as an injection and then 10 to 50 ßg somatostatin per hour as an infusion, partly intraspinally, partly intraventricularly applied. These treatments resulted in a pronounced Analgesia comparable to that of morphine. The infusions were longer than Tolerated for 2 weeks without side effects.
Es wurde weiterhin gefunden, daß intradurale oder intraspirale Injektionen und Infusionen anästhetische Wirkung haben und anstelle üblicher Anästhetika eingesetzt werden können.It was also found that intradural or intraspiral injections and infusions have an anesthetic effect and are used instead of conventional anesthetics can be.
Gegenstand der vorliegenden Erfindung ist somit die Verwendung von Somatostatin in Form von intraspinalen oder intraventrikulären Injektionen und Infusionen als Analgetikum und intradurales oder intraspinales Anästhetikum, sowie die Verwendung von Somatostatin zur Herstellung von intraspinalen oder intraventrikulären Injektions- und Infusionslösungen als Analgetikum oder Anästhetikum.The present invention thus relates to the use of Somatostatin in the form of intraspinal or intraventricular injections and infusions as an analgesic and intradural or intraspinal anesthetic, as well as the use of somatostatin for the production of intraspinal or intraventricular injection and infusion solutions as an analgesic or anesthetic.
Als In3ekt»-onslösungen kommen prinzipiell dieselben Lösungen in Frage wie gemäß der Hauptanmeldung. Bei der intraventrikulären Applikation wird durch eine künstliche Öffnung des Kopfes Zugang zum Ventrikel geschaffen und hierhinein die Infusionslösung geleitet.In principle, the same solutions can be considered as connectivity solutions as according to the main application. In the case of intraventricular application, an artificial opening in the head provides access to the ventricle and into it the infusion solution passed.
Trotz der guten Verträglichkeit wird man die jeweils applizierte Menge an Somatostatin so niedrig wie möglich halten. Einige Ergebnisse deuten darauf hin, daß die Dosierung niedriger als bisher gewählt werden kann.Despite the good tolerability, the amount applied will be used in each case keep somatostatin as low as possible. Some results suggest that the dosage can be chosen lower than before.
Claims (2)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843439716 DE3439716A1 (en) | 1984-10-30 | 1984-10-30 | Novel use of somatostatin |
| EP19850102588 EP0154940B1 (en) | 1984-03-13 | 1985-03-07 | Use of somatostatin |
| DE8585102588T DE3579479D1 (en) | 1984-03-13 | 1985-03-07 | NEW USE OF SOMATOSTATIN. |
| US06/709,549 US4670418A (en) | 1984-03-13 | 1985-03-08 | Method of using somatostatin as an analgesic or an anesthetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843439716 DE3439716A1 (en) | 1984-10-30 | 1984-10-30 | Novel use of somatostatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3439716A1 true DE3439716A1 (en) | 1986-04-30 |
Family
ID=6249119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19843439716 Withdrawn DE3439716A1 (en) | 1984-03-13 | 1984-10-30 | Novel use of somatostatin |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE3439716A1 (en) |
-
1984
- 1984-10-30 DE DE19843439716 patent/DE3439716A1/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AF | Is addition to no. |
Ref country code: DE Ref document number: 3409062 Format of ref document f/p: P |
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| 8141 | Disposal/no request for examination |