DE3414507A1 - Tablet disintegration tester with automatic time measurement complying with the requirements of DAB, USP and other pharmacopoeias - Google Patents

Tablet disintegration tester with automatic time measurement complying with the requirements of DAB, USP and other pharmacopoeias

Info

Publication number
DE3414507A1
DE3414507A1 DE19843414507 DE3414507A DE3414507A1 DE 3414507 A1 DE3414507 A1 DE 3414507A1 DE 19843414507 DE19843414507 DE 19843414507 DE 3414507 A DE3414507 A DE 3414507A DE 3414507 A1 DE3414507 A1 DE 3414507A1
Authority
DE
Germany
Prior art keywords
measurement
tablet disintegration
disintegration tester
tester according
test material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19843414507
Other languages
German (de)
Inventor
Bernhard 3380 Goslar Kohler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharma Test Apparatebau 6452 Hainburg De GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19843414507 priority Critical patent/DE3414507A1/en
Publication of DE3414507A1 publication Critical patent/DE3414507A1/en
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/006—Dissolution of tablets or the like

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Measurement of the tablet disintegration time is an international requirement. Automatic time measurement in laboratories and production plants is to provide more accurate results of the six measurement cells with print-outs. In addition, the user can do other work, and disintegration need not be monitored. In this application the following principle was applied: tablets or such like test material are pressed onto the screen in the measurement cells by the standardised disc and the lifting movement. This slight pressure is transmitted to the outside. Loss-free magnetic lever transmissions actuate digital Hall IC. Once the test material in a measurement cell has disintegrated the disc cannot press the screen downwards. Lateral noses which at the same time determine the switching threshold prevent this. The measurement basket with the six cells is immediately operative after connection. Two-coloured light-emitting diodes in the electronic part are intended for setting of the switching threshold and the disintegration time. A computer is responsible for start and stop, picks up the signals of the measurement basket, prints out the disintegration times including the mean, and finally switches the lifting device off.

Description

Bezeichnung: Tablettenzerfalltester mit automatischerDesignation: tablet disintegration tester with automatic

Zeitmessung unter Beachtung der Vorschriften des DAB, der USP und andaren Pharmaknöen.Time measurement in compliance with the regulations of the DAB, the USP and andaren pharmacopoeia.

Tastneräte dieser Art sind hekannt und können u.a. in der Patentschrift 24 09 222.6-52 oder in meiner Offenlegungschrift 27 16 985 vnm 26.10.78 ersehen werden.Key devices of this type are known and can be found in the patent specification 24 09 222.6-52 or in my disclosure document 27 16 985 of 10/26/78 will.

Gegenüber anderen Lösungen wurde hier inert geleot,die Hunststoffscheibe (Disk) nhne mechanische Veränderungen,die zu Zeitfehlern fuhren kann,zu belassen.Compared to other solutions, the plastic disk was made inert here To leave the (disk) without mechanical changes, which can lead to time errors.

Das Prinzip dieser Anmeldung ist gekennzeichnet,dat3 die Kunststoffscheibe das Sieb nicht berühren kann,solange kein Testgut,Tabletten n.ä. in der Meßkammer sind.Drei äußere Ringsegmente verhindern den Aufschlag.Ist in der Meßkammer Testqut,wird das Sieb begrenzt niedergedrückt und über einen Hebel mit Stab der Druck in den Elektronik-Hnpf geleitet.The principle of this application is marked, dat3 the plastic disc cannot touch the sieve as long as no test material, tablets etc. in the measuring chamber Three outer ring segments prevent the impact. Is test quality in the measuring chamber, will the sieve is pressed down and a lever with a rod is used to reduce the pressure in the Electronics Hnpf headed.

Es gibt viele Möglichkeiten den Druck in ein Nutzsignal umzuwandeln.Hier wurde ein Digitaler Hall-IS eingesetzt.There are many ways to convert the pressure into a useful signal, here a digital Hall-IS was used.

Eine größare Empfindlichkeit wurde durch eine Habelübersetzung erreicht,die dadurch gekennzeichnet ist,da eine permanentmaqnetische Rückfederung die Reibungs und Übertragungsverluste gering halten.Great sensitivity was achieved by a Habel translation, the is characterized in that a permanent magnetic spring back reduces the friction and keep transmission losses low.

Erklärung zur Zeichnung,dargestellt eine Meßkammer aus dem 6 fachen Zerfallkorb.Explanation of the drawing, shown a measuring chamber from the 6 times Disintegration basket.

Die dargestellte Tablette (1) in der Meßkammer (2) @ird durch die Kunststoffscheibe (3) ca.30 mal in der Minute auf das Sieb (4) gadrückt.The tablet (1) shown in the measuring chamber (2) @ is through the The plastic disc (3) is pressed onto the sieve (4) about 30 times per minute.

Die Zeit bis die Tablette zerfallen ist,wird sn erfaßt, daß das Sieb (4) federnd gelagert ist und nach unten ausweichen kann.Über den Hebelarm (5) wird die Bewenung mit dem Stab (6) nach oben in den Elektronikkopf gegeben.The time until the tablet disintegrates is detected sn that the sieve (4) is spring-loaded and can move downwards. Via the lever arm (5) the given the movement with the stick (6) up into the electronics head.

Ist die Tablette (1) zerfallen,kann die Kunststoffscheibe (3) das Sieb (4) nicht mehr berühren,da 3 äußere Rinasegmente (7) von 0,2 mm das verhindern.If the tablet (1) disintegrates, the plastic disc (3) can Do not touch the sieve (4) any more, as 3 outer ring segments (7) of 0.2 mm prevent this.

Der Elektronikkopf ist abnehmbar und wird durch die Gummimembrane (8) vor Feuchtigkeit geschützt.Stellschraube (9) und Feder zunge (10) sind für den Anlagedruck des Siebes (4) zuständig.Größere Empfindlichkeit wird mit der Hebe]-übersetzung (11)und (12) erreicht,die außerdem durch eine mannetische Federung (13) eine qeringe Reibung hat.The electronic head is removable and is secured by the rubber membrane (8) Protected from moisture. Adjusting screw (9) and spring tongue (10) are for the Contact pressure of the sieve (4) is responsible. Greater sensitivity is achieved with the lifting] transmission (11) and (12) achieved, which also by a Mannetic suspension (13) a qeringe Has friction.

Magnet (14) schaltet ein Digitales-Hall-IS (19).Mit der Spindelfuhrung (16) wird der Schaltpunkt eingestellt.Magnet (14) switches a digital Hall-IS (19) with the spindle guide (16) the switching point is set.

Tablettenzerfalltester in DMS-Ausführung sind bis auf die Positionen 11,12,13,14,15 und 16 gleich - L e e r s e i t e -DMS design tablet disintegration testers are except for items 11, 12, 13, 14, 15 and 16 the same - L e r s e i t e -

Claims (6)

Patentansprüche Baschreibung einer Meßkammer aus dem 6 fachen Zerfallkorh.Claims Description of a measuring chamber from the 6-fold decay corh. 1. Tablettenzerfalltester dadurch @ekennzeichnet,daß das Sieb federnd nach unten gelagert ist.Solange kein Testgut in der Meßkammer ist,kann das Sieb nicht durch die Kunststoffscheibe gedrückt werden.Drei äußere Ringsaqmente verhindern den Aufschlag.Ausschlaggebend dafür ist die gencrmte Hubbrewegung von 50-55 mm,30 mal in der Minute.1. Tablet disintegration tester characterized @ e that the sieve is resilient As long as there is no test material in the measuring chamber, the sieve are not pushed through the plastic disc. Prevent three outer rings The decisive factor for this is the specified stroke movement of 50-55 mm, 30 times a minute. Ist Testgut in der Meßkammer,wird das Sieb begrenzt nach unten ge@rückt.Der Zerfall ist bendet wenn das Tastgut einen Rest von ca.0,2 mm hat.If the test material is in the measuring chamber, the sieve is pushed down to a limited extent Disintegration is over when the object to be scanned has a residue of about 0.2 mm. 2.Tablettenzerfalltester nach Ansnruch 1 dadurch qPkPnnzeichnet,daß der Siabdruck über Hebel und Stab in den Elektrogikkopr geleitet wird.2. tablet disintegration tester according to claim 1 characterized by qPkPnn that the imprint is fed into the electrogikkopr using a lever and rod. 3.Tablttenzerfalltester nach Anspruch 1 und 2,dadurch gekennzeishnet,daß eine Hebelübersetzung im Elpktronikkopf den Druck vergrößert.Eine permanentmagnetische Rüskfederunn hält Reibung und Übertragungsverlusts gering. 3. tablet disintegration tester according to claim 1 and 2, characterized in that a leverage in the electronic head increases the pressure; a permanent magnetic one Rüskfederunn keeps friction and transmission loss low. 4.Tablettenzerfalltester nach Anspruch 1,2 und 3 dadurch gekannzeichnet,daß der Druck durch den Einbau eines Digitalen Hall-IS in ein Nutzsignal umgewandelt wird.4. tablet disintegration tester according to claim 1, 2 and 3, characterized in that the pressure is converted into a useful signal by installing a digital Hall-IS will. 5. Tablettenzerfalltester nach Anspruch 1,2,3, und 4, dadurch gekennzeichnet,daß statt dem Digitalen Hall-IS Dehnungs-Meßstreifen (DMS) in Brückenschaltung und DP-Verstürker das Nutzsignal arzeugen.5. tablet disintegration tester according to claim 1, 2, 3, and 4, characterized in that instead of the digital Hall-IS strain gauges (DMS) in bridge circuit and DP amplifier generate the useful signal. 6. Tablettenzerfalltester nach Anspruch 1,2,3,4 und 5, dadurch nekennzeichnet,daE der Druck ein Piezoelement zur Erzeuqunn des Nu tzsinnales varmentdet.6. tablet disintegration tester according to claim 1, 2, 3, 4 and 5, characterized in that daE the pressure varmentdet a piezo element to generate the usefulness.
DE19843414507 1984-04-10 1984-04-10 Tablet disintegration tester with automatic time measurement complying with the requirements of DAB, USP and other pharmacopoeias Ceased DE3414507A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19843414507 DE3414507A1 (en) 1984-04-10 1984-04-10 Tablet disintegration tester with automatic time measurement complying with the requirements of DAB, USP and other pharmacopoeias

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843414507 DE3414507A1 (en) 1984-04-10 1984-04-10 Tablet disintegration tester with automatic time measurement complying with the requirements of DAB, USP and other pharmacopoeias

Publications (1)

Publication Number Publication Date
DE3414507A1 true DE3414507A1 (en) 1985-10-17

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Family Applications (1)

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DE19843414507 Ceased DE3414507A1 (en) 1984-04-10 1984-04-10 Tablet disintegration tester with automatic time measurement complying with the requirements of DAB, USP and other pharmacopoeias

Country Status (1)

Country Link
DE (1) DE3414507A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997014035A1 (en) * 1995-10-06 1997-04-17 Loeffler Hans Peter Device for determining the dissolution time of medicaments in pressed form, like tablets, pills or capsules
WO1998050776A1 (en) * 1997-05-07 1998-11-12 Kraemer Norbert Device for determining the decay time of compressed medicaments such as tablets and capsules, and corresponding method
CN103411838A (en) * 2013-07-30 2013-11-27 内蒙古科技大学 Method and device for measuring small elongation of solid material by using levers and Hall integrator

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2409222C2 (en) * 1974-02-27 1975-11-13 Sandoz Ag, 8500 Nuernberg Tablet disintegration tester
DE2716985A1 (en) * 1977-04-18 1978-10-26 Bernhard Kohler Pharmaceutical tablet strength tester - uses piezo-transducer to detect displacement pulses transmitted through tablets before disintegration

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2409222C2 (en) * 1974-02-27 1975-11-13 Sandoz Ag, 8500 Nuernberg Tablet disintegration tester
DE2716985A1 (en) * 1977-04-18 1978-10-26 Bernhard Kohler Pharmaceutical tablet strength tester - uses piezo-transducer to detect displacement pulses transmitted through tablets before disintegration

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997014035A1 (en) * 1995-10-06 1997-04-17 Loeffler Hans Peter Device for determining the dissolution time of medicaments in pressed form, like tablets, pills or capsules
US6163149A (en) * 1995-10-06 2000-12-19 Loeffler; Hans-Peter Device for determining the dissolution time of medicaments in pressed form, like tablets, pills or capsules
WO1998050776A1 (en) * 1997-05-07 1998-11-12 Kraemer Norbert Device for determining the decay time of compressed medicaments such as tablets and capsules, and corresponding method
US6484595B1 (en) 1997-05-07 2002-11-26 Kraemer Norbert Device for determining the disintegration time of compressed pharmaceutical mold bodies, such as tablets and capsules, as well as a method for this purpose
CN103411838A (en) * 2013-07-30 2013-11-27 内蒙古科技大学 Method and device for measuring small elongation of solid material by using levers and Hall integrator
CN103411838B (en) * 2013-07-30 2016-06-08 内蒙古科技大学 Method and the device of solid material Chroococcus minutus is measured by lever and Hall integrator

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: KOHLER, BERNHARD, 7770 UEBERLINGEN, DE

8127 New person/name/address of the applicant

Owner name: PHARMA TEST APPARATEBAU GMBH, 6452 HAINBURG, DE

8181 Inventor (new situation)

Free format text: KOHLER, BERNHARD, 7770 UEBERLINGEN, DE

8110 Request for examination paragraph 44
8131 Rejection