DE3376650D1 - 1,2,3,4-tetrahydro-1-aminomethyl-4-phenyl isoquinolines and methods of preparation - Google Patents

1,2,3,4-tetrahydro-1-aminomethyl-4-phenyl isoquinolines and methods of preparation

Info

Publication number
DE3376650D1
DE3376650D1 DE8383109410T DE3376650T DE3376650D1 DE 3376650 D1 DE3376650 D1 DE 3376650D1 DE 8383109410 T DE8383109410 T DE 8383109410T DE 3376650 T DE3376650 T DE 3376650T DE 3376650 D1 DE3376650 D1 DE 3376650D1
Authority
DE
Germany
Prior art keywords
aminomethyl
tetrahydro
preparation
methods
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383109410T
Other languages
English (en)
Inventor
Ronald C Griffith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pennwalt Corp
Original Assignee
Pennwalt Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pennwalt Corp filed Critical Pennwalt Corp
Application granted granted Critical
Publication of DE3376650D1 publication Critical patent/DE3376650D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8383109410T 1982-09-27 1983-09-21 1,2,3,4-tetrahydro-1-aminomethyl-4-phenyl isoquinolines and methods of preparation Expired DE3376650D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/423,958 US4518779A (en) 1982-09-27 1982-09-27 1,2,3,4-Tetrahydro-1-aminomethyl-4-phenyl isoquinolines

Publications (1)

Publication Number Publication Date
DE3376650D1 true DE3376650D1 (en) 1988-06-23

Family

ID=23680888

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383109410T Expired DE3376650D1 (en) 1982-09-27 1983-09-21 1,2,3,4-tetrahydro-1-aminomethyl-4-phenyl isoquinolines and methods of preparation

Country Status (17)

Country Link
US (1) US4518779A (de)
EP (1) EP0104604B1 (de)
JP (1) JPS5978164A (de)
KR (1) KR840006209A (de)
AT (1) ATE34386T1 (de)
AU (1) AU564040B2 (de)
BR (1) BR8305272A (de)
CA (1) CA1228360A (de)
DE (1) DE3376650D1 (de)
DK (1) DK438883A (de)
FI (1) FI833443A (de)
IE (1) IE55970B1 (de)
IL (1) IL69624A (de)
NO (1) NO833465L (de)
NZ (1) NZ205422A (de)
PH (1) PH19712A (de)
ZA (1) ZA836330B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE97893T1 (de) * 1988-02-19 1993-12-15 Smithkline Beecham Farma 1,2,3,4-tetrahydroisoquinoline, verfharen zu ihrer herstellung und ihre verwendung als kappa- rezeptor agonisten.
GB8827479D0 (en) * 1988-11-24 1988-12-29 Zambeletti Spa L Novel compounds
UA125519C2 (uk) * 2016-07-29 2022-04-13 Суновіон Фармасьютікалз Інк. Сполуки і композиції і їх застосування

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3420818A (en) * 1964-08-07 1969-01-07 Sandoz Ag Tetrahydroisoquinolines
US3435038A (en) * 1965-06-01 1969-03-25 Sandoz Ag 5,6,7,9,10,14b-hexahydroisoquinolo (2,1-d) benzo (1,4) diazepines
US3666763A (en) * 1970-01-06 1972-05-30 Hoffmann La Roche 4-phenyl isoquinolines and process for preparing same
SE417092B (sv) * 1974-11-06 1981-02-23 Fujisawa Pharmaceutical Co Forfarande for framstellning av 1,2,3,4-tetrahydroisokinoliner
DE2811361A1 (de) * 1978-03-16 1979-09-27 Hoechst Ag Neue isochinolinaldehyde und verfahren zu ihrer herstellung
JPS5587771A (en) * 1978-12-27 1980-07-02 Teikoku Hormone Mfg Co Ltd 1-phenylisoquinoline derivative
DE3011156A1 (de) * 1980-03-22 1981-10-01 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur herstellung von isochinolinderivaten
US4340600A (en) * 1980-05-22 1982-07-20 Smithkline Corporation Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines

Also Published As

Publication number Publication date
BR8305272A (pt) 1984-05-02
ZA836330B (en) 1984-07-25
AU564040B2 (en) 1987-07-30
IE55970B1 (en) 1991-03-13
CA1228360A (en) 1987-10-20
FI833443A (fi) 1984-03-28
KR840006209A (ko) 1984-11-22
ATE34386T1 (de) 1988-06-15
IE832205L (en) 1984-03-27
DK438883A (da) 1984-03-28
NO833465L (no) 1984-03-28
PH19712A (en) 1986-06-17
IL69624A (en) 1987-01-30
NZ205422A (en) 1986-07-11
DK438883D0 (da) 1983-09-26
US4518779A (en) 1985-05-21
IL69624A0 (en) 1983-12-30
EP0104604B1 (de) 1988-05-18
JPS5978164A (ja) 1984-05-04
EP0104604A1 (de) 1984-04-04
AU1911283A (en) 1984-04-05
FI833443A0 (fi) 1983-09-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee