DE3376115D1 - Gnrh antagonists - Google Patents

Gnrh antagonists

Info

Publication number
DE3376115D1
DE3376115D1 DE8383304265T DE3376115T DE3376115D1 DE 3376115 D1 DE3376115 D1 DE 3376115D1 DE 8383304265 T DE8383304265 T DE 8383304265T DE 3376115 T DE3376115 T DE 3376115T DE 3376115 D1 DE3376115 D1 DE 3376115D1
Authority
DE
Germany
Prior art keywords
sub
phe
gonads
steroids
sup
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383304265T
Other languages
English (en)
Inventor
Jean Edouard Frederic Rivier
Wylie Walker Vale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Application granted granted Critical
Publication of DE3376115D1 publication Critical patent/DE3376115D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8383304265T 1982-07-26 1983-07-22 Gnrh antagonists Expired DE3376115D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/402,117 US4444759A (en) 1982-07-26 1982-07-26 GnRH Antagonists II

Publications (1)

Publication Number Publication Date
DE3376115D1 true DE3376115D1 (en) 1988-05-05

Family

ID=23590595

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383304265T Expired DE3376115D1 (en) 1982-07-26 1983-07-22 Gnrh antagonists

Country Status (21)

Country Link
US (1) US4444759A (de)
EP (1) EP0100218B1 (de)
JP (1) JPS5946253A (de)
KR (1) KR900003096B1 (de)
AT (1) ATE33252T1 (de)
AU (1) AU558402B2 (de)
CA (1) CA1263500A (de)
DD (1) DD216923A5 (de)
DE (1) DE3376115D1 (de)
DK (1) DK328183A (de)
ES (1) ES8505335A1 (de)
GR (1) GR78886B (de)
HU (1) HU191865B (de)
IE (1) IE55580B1 (de)
IL (1) IL69098A (de)
MX (1) MX7312E (de)
NO (1) NO832671L (de)
NZ (1) NZ204692A (de)
PH (1) PH18967A (de)
PT (1) PT77067B (de)
ZA (1) ZA834645B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL70888A0 (en) * 1983-03-10 1984-05-31 Salk Inst For Biological Studi Gn rh antagonist peptides and pharmaceutical compositions containing them
US4619914A (en) * 1983-03-10 1986-10-28 The Salk Institute For Biological Studies GNRH antagonists IIIB
ZA846154B (en) * 1983-08-16 1985-03-27 Akzo Nv Lh-rh antagonists
EP0145032B1 (de) * 1983-08-16 1987-11-04 Akzo N.V. LH/RH-Antagonisten
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
US4569927A (en) * 1984-02-23 1986-02-11 The Salk Institute For Biological Studies GnRH Antagonists IV
IL74827A (en) * 1984-05-21 1989-06-30 Salk Inst For Biological Studi Peptides active as gnrh antagonists and pharmaceutical compositions containing them
US4652550A (en) * 1984-05-21 1987-03-24 The Salk Institute For Biological Studies GnRH antagonists VII
US4647653A (en) * 1984-08-23 1987-03-03 Tulane Educational Fund Therapeutic peptides
US4565804A (en) * 1984-09-07 1986-01-21 The Salk Institute For Biological Studies GnRH Antagonists VI
US4866160A (en) * 1985-04-09 1989-09-12 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
ZA862570B (en) * 1985-04-09 1986-12-30 Univ Tulane Therapeutic decapeptides
US4705778A (en) * 1985-10-22 1987-11-10 Sri International Orally active LHRH analogs
DE3634435A1 (de) * 1986-10-09 1988-04-14 Hoechst Ag Analoga von gonadoliberin mit verbesserter loeslichkeit, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
EP0400065B1 (de) * 1988-02-10 1997-08-27 TAP Pharmaceuticals Inc. Lhrh-analog
US5300492A (en) * 1988-02-10 1994-04-05 Tap Pharmaceuticals LHRH analogs
WO1990009799A1 (en) * 1989-02-23 1990-09-07 Colorado State University Research Foundation GnRH ANALOGS FOR DESTROYING GONADOTROPHS
US6326467B1 (en) 1989-02-23 2001-12-04 Colorado State University Research Foundation Hormone-recombinant toxin compounds and methods for using same
US5786457A (en) * 1989-02-23 1998-07-28 Colorado State University Research Foundation Hormone-nuclease compounds and method for regulating hormone related diseases
US5084443A (en) * 1989-12-04 1992-01-28 Biomeasure, Inc. Promoting expression of acetylcholine receptors with lhrh antagonist
US5965695A (en) * 1990-05-15 1999-10-12 Chiron Corporation Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
IE66205B1 (en) * 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5656727A (en) * 1992-09-15 1997-08-12 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
US5480969A (en) * 1992-09-15 1996-01-02 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
US20050277582A1 (en) * 1993-07-20 2005-12-15 Nett Torrance M Method for inactivating gonadotrophs
US5502035A (en) * 1993-08-06 1996-03-26 Tap Holdings Inc. N-terminus modified analogs of LHRH
US5506207A (en) * 1994-03-18 1996-04-09 The Salk Institute For Biological Studies GNRH antagonists XIII
US5843901A (en) 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US6455499B1 (en) 1999-02-23 2002-09-24 Indiana University Foundation Methods for treating disorders associated with LHRH activity
US6598784B2 (en) * 2000-12-20 2003-07-29 Meadwestvaco Packaging Syatens, Llc Beverage carton with strap type carrying handle
JP2017517484A (ja) 2014-03-31 2017-06-29 イオテック インターナショナル， インコーポレイテッド 非錯体化ヨウ素の安定な組成物及び使用方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261887A (en) * 1973-11-06 1981-04-14 The Salk Institute For Biological Studies Peptide compositions
US4072668A (en) * 1973-11-06 1978-02-07 The Salk Institute For Biological Studies LH-RH Analogs
DE2617646C2 (de) * 1976-04-22 1986-07-31 Hoechst Ag, 6230 Frankfurt Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
US4215038A (en) * 1978-10-16 1980-07-29 The Salk Institute For Biological Studies Peptides which inhibit gonadal function
US4307083A (en) * 1978-10-16 1981-12-22 The Salk Institute For Biological Studies LRF Antagonists
GB2053229B (en) * 1979-06-13 1983-03-02 Schally Andrew Victor Lh-rh antagonists
US4253997A (en) * 1979-12-17 1981-03-03 American Home Products Corporation Anti-ovulatory decapeptides
US4292313A (en) * 1980-04-15 1981-09-29 The Salk Institute For Biological Studies LRF Antagonists
DE3165535D1 (en) * 1980-06-02 1984-09-20 Andrew Victor Schally Lh-rh antagonists
US4341767A (en) * 1980-10-06 1982-07-27 Syntex Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
AU9102582A (en) * 1981-12-10 1983-06-16 David Howard Coy Lh-rh antagonists

Also Published As

Publication number Publication date
ZA834645B (en) 1984-03-28
PT77067A (en) 1983-08-01
DK328183A (da) 1984-01-27
DK328183D0 (da) 1983-07-15
IE831582L (en) 1984-01-26
PH18967A (en) 1985-11-26
CA1263500A (en) 1989-11-28
ATE33252T1 (de) 1988-04-15
HU191865B (en) 1987-04-28
IE55580B1 (en) 1990-11-07
IL69098A (en) 1986-09-30
EP0100218B1 (de) 1988-03-30
DD216923A5 (de) 1985-01-02
ES524370A0 (es) 1985-05-16
KR900003096B1 (ko) 1990-05-07
GR78886B (de) 1984-10-02
AU558402B2 (en) 1987-01-29
NO832671L (no) 1984-01-27
IL69098A0 (en) 1983-10-31
NZ204692A (en) 1986-03-14
EP0100218A2 (de) 1984-02-08
PT77067B (en) 1986-01-27
MX7312E (es) 1988-05-11
JPS5946253A (ja) 1984-03-15
AU1637183A (en) 1984-02-02
ES8505335A1 (es) 1985-05-16
US4444759A (en) 1984-04-24
EP0100218A3 (en) 1984-08-15
KR840005710A (ko) 1984-11-15

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DE3376115D1 (en) Gnrh antagonists
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ES8307720A1 (es) "un metodo para la preparacion de peptidos antagonistas de una hormona hipotalamica".
ES8504677A1 (es) Un procedimiento para obtener un peptido o una sal no toxica del mismo.
ES8207510A1 (es) Un metodo de preparacion de un peptido inhibidor de la liberacion de gonadotropinas por la glandula pituitaria en mamiferos.
GB2089209A (en) Contraceptive treatment of male mammals

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee