DE3269474D1 - Thiazole derivatives and their use in the manufacture of beta-lactam antibiotics - Google Patents
Thiazole derivatives and their use in the manufacture of beta-lactam antibioticsInfo
- Publication number
- DE3269474D1 DE3269474D1 DE8282306043T DE3269474T DE3269474D1 DE 3269474 D1 DE3269474 D1 DE 3269474D1 DE 8282306043 T DE8282306043 T DE 8282306043T DE 3269474 T DE3269474 T DE 3269474T DE 3269474 D1 DE3269474 D1 DE 3269474D1
- Authority
- DE
- Germany
- Prior art keywords
- beta
- lactam antibiotics
- manufacture
- thiazole derivatives
- triphenylmethylaminothiazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003782 beta lactam antibiotic agent Substances 0.000 title abstract 2
- 239000002132 β-lactam antibiotic Substances 0.000 title abstract 2
- 229940124586 β-lactam antibiotics Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000007979 thiazole derivatives Chemical class 0.000 title 1
- NNPMQIDYDOOKNK-WYWVCWIXSA-N Cl.CN(C)C=O.CCOC(=O)C(=N/O)\C1=CSC(NC(C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=N1 Chemical compound Cl.CN(C)C=O.CCOC(=O)C(=N/O)\C1=CSC(NC(C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=N1 NNPMQIDYDOOKNK-WYWVCWIXSA-N 0.000 abstract 1
- 229960003644 aztreonam Drugs 0.000 abstract 1
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 abstract 1
- 229960003791 cefmenoxime Drugs 0.000 abstract 1
- HJJDBAOLQAWBMH-YCRCPZNHSA-N cefmenoxime Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NN=NN1C HJJDBAOLQAWBMH-YCRCPZNHSA-N 0.000 abstract 1
- 229960001958 cefodizime Drugs 0.000 abstract 1
- XDZKBRJLTGRPSS-BGZQYGJUSA-N cefodizime Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(C)=C(CC(O)=O)S1 XDZKBRJLTGRPSS-BGZQYGJUSA-N 0.000 abstract 1
- 229960004261 cefotaxime Drugs 0.000 abstract 1
- GPRBEKHLDVQUJE-VINNURBNSA-N cefotaxime Chemical compound N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C(O)=O)=O)C(=O)/C(=N/OC)C1=CSC(N)=N1 GPRBEKHLDVQUJE-VINNURBNSA-N 0.000 abstract 1
- 229960000484 ceftazidime Drugs 0.000 abstract 1
- ORFOPKXBNMVMKC-DWVKKRMSSA-N ceftazidime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 ORFOPKXBNMVMKC-DWVKKRMSSA-N 0.000 abstract 1
- 229960001991 ceftizoxime Drugs 0.000 abstract 1
- NNULBSISHYWZJU-LLKWHZGFSA-N ceftizoxime Chemical compound N([C@@H]1C(N2C(=CCS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 NNULBSISHYWZJU-LLKWHZGFSA-N 0.000 abstract 1
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8134359 | 1981-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3269474D1 true DE3269474D1 (en) | 1986-04-03 |
Family
ID=10525889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8282306043T Expired DE3269474D1 (en) | 1981-11-13 | 1982-11-12 | Thiazole derivatives and their use in the manufacture of beta-lactam antibiotics |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US4510312A (enExample) |
| EP (1) | EP0088847B1 (enExample) |
| JP (1) | JPS58135872A (enExample) |
| AT (1) | ATE18219T1 (enExample) |
| DE (1) | DE3269474D1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3269474D1 (en) * | 1981-11-13 | 1986-04-03 | Glaxo Group Ltd | Thiazole derivatives and their use in the manufacture of beta-lactam antibiotics |
| US4426528A (en) * | 1982-04-01 | 1984-01-17 | Eli Lilly And Company | Purification of syn-(2-aminothiazol-4-yl)methoxyimino)acetic acid |
| CN103804395B (zh) * | 2014-01-16 | 2015-12-02 | 天津大学 | 头孢噻肟钠n,n-二甲基甲酰胺溶剂化合物及制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
| DE2760123C2 (de) * | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
| US4166115A (en) * | 1976-04-12 | 1979-08-28 | Fujisawa Pharmaceutical Co., Ltd. | Syn 7-oxoimino substituted derivatives of cephalosporanic acid |
| PH17188A (en) * | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
| SE439312B (sv) * | 1977-03-25 | 1985-06-10 | Roussel Uclaf | Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra |
| AR229883A1 (es) * | 1978-05-26 | 1983-12-30 | Glaxo Group Ltd | Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato |
| DE3269474D1 (en) * | 1981-11-13 | 1986-04-03 | Glaxo Group Ltd | Thiazole derivatives and their use in the manufacture of beta-lactam antibiotics |
-
1982
- 1982-11-12 DE DE8282306043T patent/DE3269474D1/de not_active Expired
- 1982-11-12 EP EP82306043A patent/EP0088847B1/en not_active Expired
- 1982-11-12 JP JP57197859A patent/JPS58135872A/ja active Granted
- 1982-11-12 AT AT82306043T patent/ATE18219T1/de not_active IP Right Cessation
- 1982-11-12 US US06/441,249 patent/US4510312A/en not_active Expired - Lifetime
-
1984
- 1984-11-19 US US06/673,095 patent/US4670552A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0088847A1 (en) | 1983-09-21 |
| JPS58135872A (ja) | 1983-08-12 |
| US4670552A (en) | 1987-06-02 |
| US4510312A (en) | 1985-04-09 |
| ATE18219T1 (de) | 1986-03-15 |
| JPH0354661B2 (enExample) | 1991-08-20 |
| EP0088847B1 (en) | 1986-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL61227A (en) | Solid solvate of syn-7-(2-amino-4-thiazolyl)(methoxyimino)-acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid and its isolation | |
| IL59793A (en) | Derivatives of(6r,7r)-7-((z)-2-(2-aminothiazol-4-yl)-2-(carboxy-(lower alkyl or cycloalkyl)oxyimino)acetamido)-3-(1-pyridinium-methyl)ceph-3-em-4-carboxylate,process for their preparation and pharmaceutical compositions comprising them | |
| DE3880047D1 (de) | Zusammensetzung eines zusatzes. | |
| BR9709654A (pt) | Derivados da tiazolidina-2,4-diona substituídos seus processos de obtenção e as composições farmacêuticas que os contêm | |
| NO822538L (no) | Fremgangsmaate for fremstilling av antibakterielle beta-laktam-derivater. | |
| IT8048772A0 (it) | Intermedi per la preparazione di antibiotici cefalosporinici eprocedimento per prepararli | |
| ES8200695A1 (es) | Procedimiento para la preparacion de cefalosporinas cromofo-ras | |
| NO871028L (no) | Analogifremgangsmte for fremstilling av terapeutisk aktive tiazol- og oksazol-derivater. | |
| NO883392D0 (no) | Fremgangsmaate ved fremstilling av tiometyl- og sulfinylmetylderivater. | |
| IL58717A (en) | Derivatives of(6r,7r)-7-((z)-2-(2-aminothiazol-4-yl)-2-(carboxy-(lower alkyl or cycloalkyl)oxyimino)acetamido)-3-(2-alkyl-pyrazolium-1-ylmethyl)ceph-3-em-4-carboxylate,process for their preparation and pharmaceutical compositions comprising them | |
| NO902977D0 (no) | Framgangsmaate for tilvirkning av keramer og keramiske komposittlegemer. | |
| NO893329D0 (no) | Fremgangsmaate for fremstilling av titanoksyd. | |
| IT8022243A0 (it) | Derivati di vinil-3 cefalosporine, e loro preparazione. | |
| NO883833L (no) | Fremgangsmaate for fremstilling av isoxazol-betacarbolinderivater. | |
| AU532294B2 (en) | Alkyloximes of 7-(2-amino-4-thiazolyl) - acetamido- cephalosporanic acids | |
| IL70664A (en) | 7-substituted 3-(3-pyridinyl)-1h,3h-pyrrolo(1,2-c)thiazole derivatives,their preparation and pharmaceutical compositions containing them | |
| ATE18219T1 (de) | Thiazol-derivate und ihre verwendung bei der herstellung von beta-lactam-antibiotika. | |
| DE3061614D1 (en) | 2,3-dihydro-imidazo (2,1-b) benzothiazole derivatives and pharmaceutical compositions containing them | |
| AU7188491A (en) | Hybridization probes for the detection of (branhamella catarrhalis) strains | |
| AU532251B2 (en) | N-substituted thiazolyl derivatives of oxy-imino-substituted cephalosporins | |
| DE3265277D1 (en) | Thiazole derivatives and their use in the manufacture of beta lactam antibiotics | |
| NO882335L (no) | Fremgangsmaate for fremstilling av 5-(omega-ammonio-acyloksy-metylen)-tetrahydrofuraner og -tetrahydrotiofener. | |
| FI872363A7 (fi) | Bakteriosiinit ja niitä sisältävät koostumukset virusinfektioiden detektioon ja hoitoon. | |
| NO905520L (no) | Rifamycinderivater og fremgangsmaater for fremstilling av disse. | |
| PH14476A (en) | L-or dl-6-(m-(3-isothiazole-5-carboxamido)phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole compound,its anthelmintic composition and method of use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |