DE3265871D1 - 3-amino-2-hydroxy-4-phenylbutanoic acid derivatives and pharmaceutical composition containing the same - Google Patents

3-amino-2-hydroxy-4-phenylbutanoic acid derivatives and pharmaceutical composition containing the same

Info

Publication number
DE3265871D1
DE3265871D1 DE8282401879T DE3265871T DE3265871D1 DE 3265871 D1 DE3265871 D1 DE 3265871D1 DE 8282401879 T DE8282401879 T DE 8282401879T DE 3265871 T DE3265871 T DE 3265871T DE 3265871 D1 DE3265871 D1 DE 3265871D1
Authority
DE
Germany
Prior art keywords
hydroxy
amino
pharmaceutical composition
same
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282401879T
Other languages
English (en)
Inventor
Hamao Umezawa
Tomio Takeuchi
Takaaki Aoyagi
Mitsugu Hachisu
Kenji Kawamura
Shunzo Fukatsu
Yasuharu Sekizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Application granted granted Critical
Publication of DE3265871D1 publication Critical patent/DE3265871D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8282401879T 1981-10-13 1982-10-13 3-amino-2-hydroxy-4-phenylbutanoic acid derivatives and pharmaceutical composition containing the same Expired DE3265871D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56161994A JPS5865260A (ja) 1981-10-13 1981-10-13 ３−アミノ−２−ヒドロキシ−４−フエニル酪酸誘導体および医薬組成物

Publications (1)

Publication Number Publication Date
DE3265871D1 true DE3265871D1 (en) 1985-10-03

Family

ID=15746009

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282401879T Expired DE3265871D1 (en) 1981-10-13 1982-10-13 3-amino-2-hydroxy-4-phenylbutanoic acid derivatives and pharmaceutical composition containing the same

Country Status (4)

Country Link
US (1) US4474764A (de)
EP (1) EP0077274B1 (de)
JP (1) JPS5865260A (de)
DE (1) DE3265871D1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI88400C (fi) * 1984-08-06 1993-05-10 Upjohn Co Foerfarande foer framstaellning av renin inhiberande peptider
US4725583A (en) * 1985-01-23 1988-02-16 Abbott Laboratories Functionalized peptidylaminoalcohols
US6117842A (en) * 1998-03-09 2000-09-12 Merck & Co., Inc. Fibrinogen receptor antagonists
WO1999045939A1 (en) * 1998-03-09 1999-09-16 Merck & Co., Inc. Fibrinogen receptor antagonists
KR101442897B1 (ko) 2009-05-28 2014-09-23 노파르티스 아게 네프릴리신 억제제로서의 치환된 아미노프로피온산 유도체
SG176010A1 (en) 2009-05-28 2011-12-29 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
BR112015019307A8 (pt) 2013-02-14 2018-01-30 Novartis Ag derivados de ácido butanóico substituído com bisfenila, seus usos, e composição farmacêutica
NZ710574A (en) 2013-02-14 2017-11-24 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
EP3268085A4 (de) 2015-03-13 2018-10-31 The Board of Trustees of The Leland Stanford Junior University Ltb4-hemmung zur vorbeugung und behandlung von lymphödem beim menschen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052449A (en) * 1974-07-01 1977-10-04 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Biologically active substance, bestatin, and production thereof
US4189604A (en) * 1975-07-22 1980-02-19 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Bestatin
GB1540019A (en) * 1977-06-01 1979-02-07 Microbial Chem Res Found Bestatin derivatives
JPS6026099B2 (ja) * 1977-09-21 1985-06-21 財団法人微生物化学研究会 ペプチド、その酸附加塩およびその製造法
JPS5767516A (en) * 1980-09-24 1982-04-24 Microbial Chem Res Found Novel analgesic agent

Also Published As

Publication number Publication date
JPS5865260A (ja) 1983-04-18
EP0077274A1 (de) 1983-04-20
JPH027943B2 (de) 1990-02-21
EP0077274B1 (de) 1985-08-28
US4474764A (en) 1984-10-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

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