DE3172648D1 - Cationic lipophilic complexes of 99m tc useful for myocardial and hepatobiliary imaging - Google Patents

Cationic lipophilic complexes of 99m tc useful for myocardial and hepatobiliary imaging

Info

Publication number
DE3172648D1
DE3172648D1 DE8181400618T DE3172648T DE3172648D1 DE 3172648 D1 DE3172648 D1 DE 3172648D1 DE 8181400618 T DE8181400618 T DE 8181400618T DE 3172648 T DE3172648 T DE 3172648T DE 3172648 D1 DE3172648 D1 DE 3172648D1
Authority
DE
Germany
Prior art keywords
myocardial
useful
cationic lipophilic
lipophilic complexes
hepatobiliary imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181400618T
Other languages
English (en)
Inventor
Edward A Deutsch
Kenneth A Glavan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RESEARCH CORPORATION TECHNOLOGIES, INC. (N.D.GES.D
Original Assignee
Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39264353&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3172648(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Research Corp filed Critical Research Corp
Application granted granted Critical
Publication of DE3172648D1 publication Critical patent/DE3172648D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5045—Complexes or chelates of phosphines with metallic compounds or metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE8181400618T 1980-04-18 1981-04-17 Cationic lipophilic complexes of 99m tc useful for myocardial and hepatobiliary imaging Expired DE3172648D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/141,618 US4387087A (en) 1980-04-18 1980-04-18 Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging
US06/290,268 US4419339A (en) 1980-04-18 1981-08-05 Formulation and method of making cationic lipophilic complexes

Publications (1)

Publication Number Publication Date
DE3172648D1 true DE3172648D1 (en) 1985-11-21

Family

ID=39264353

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181400618T Expired DE3172648D1 (en) 1980-04-18 1981-04-17 Cationic lipophilic complexes of 99m tc useful for myocardial and hepatobiliary imaging

Country Status (7)

Country Link
US (2) US4387087A (de)
EP (1) EP0038756B1 (de)
JP (2) JPS5735523A (de)
CA (1) CA1177091A (de)
DE (1) DE3172648D1 (de)
HK (1) HK81186A (de)
IE (1) IE51240B1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5831686B2 (ja) * 1979-12-27 1983-07-07 古河電気工業株式会社 超電導ケ−ブル
US4512967A (en) * 1982-08-02 1985-04-23 E. I. Du Pont De Nemours And Compamy Cationic technetium complexes useful as radiodiagnostic agents
US4451450A (en) * 1981-10-15 1984-05-29 New England Nuclear Corporation Cationic compounds useful for making radiodiagnostic agents
DE3277201D1 (en) * 1981-10-15 1987-10-15 Du Pont Cationic compounds useful for making radiodiagnostic agents
US4455291A (en) * 1982-01-22 1984-06-19 New England Nuclear Corporation Accelerators for forming cationic technetium complexes useful as radiodiagnostic agents
US4374821A (en) * 1982-06-28 1983-02-22 E. R. Squibb & Sons, Inc. Myocardial imaging agent and method
USRE32826E (en) * 1982-08-02 1989-01-10 E. I Du Pont De Nemours And Company Cationic technetium complexes useful as radiodiagnostic agents
US4497790A (en) * 1982-09-03 1985-02-05 E. I. Du Pont De Nemours And Company, Inc. Method for forming cationic technetium complexes useful as radiodiagnostic agents
US4446123A (en) * 1982-10-13 1984-05-01 Hahnemann University Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations
US4481184A (en) * 1983-02-14 1984-11-06 E. R. Squibb & Sons, Inc. Cationic technetium (I) complexes
US4526776A (en) * 1983-04-15 1985-07-02 E. I. Du Pont De Nemours & Company Cationic cyanato and thiocyanato complexes useful as radiodiagnostic agents
GB8310438D0 (en) * 1983-04-18 1983-05-25 Amersham Int Plc Bone-seeking complexes of technetium-99m
US4615876A (en) * 1983-04-25 1986-10-07 Curators Of The University Of Missouri Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides
US4515767A (en) * 1983-06-20 1985-05-07 The Dow Chemical Company Radioactive metals complexed with phosphonate derivatives of dicyclopentadienebis(methylamine)
US4582698A (en) * 1983-09-19 1986-04-15 The Dow Chemical Company Process for imaging cardiac infarcts
US4508704A (en) * 1984-02-27 1985-04-02 The Dow Chemical Company Radioactive metals complexed with phosphonate derivatives of bicycloheptane bis(alkylamines)
US4560548A (en) * 1984-04-10 1985-12-24 The Dow Chemical Company Bone seeking Tc-99m complexes of phosphonate derivatives of bis(aminoalkyl)piperazine
US4707544A (en) * 1984-11-28 1987-11-17 President And Fellows Of Harvard College Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents
US4617184A (en) * 1984-11-29 1986-10-14 Tsolis Alexandros K 99m Tc-1,2-dihydroxy-1,2-bis(dihydroxyphosphinyl)ethane complex for skeleton scanning
US4789543A (en) * 1984-11-30 1988-12-06 E. I. Du Pont De Nemours And Company Neutral technetium 99-m complexes useful as radiodiagnostic agents
US4705849A (en) * 1985-04-15 1987-11-10 E. R. Squibb & Sons, Inc. Boronic acid adducts of technetium-99m dioxime complexes
US4698422A (en) * 1985-05-20 1987-10-06 Smithkline Beckman Corporation Triphos and tetraphos gold compounds and ligands
US4894445A (en) * 1985-08-05 1990-01-16 E. I. Du Pont De Nemours And Company Metal-isonitrile adducts for preparing radionuclide complexes
US4778672A (en) * 1985-11-27 1988-10-18 University Of Cincinnati Method of isolating radioactive perrhenate or pertechnetate from an aqueous solution
GB8531296D0 (en) * 1985-12-19 1986-01-29 Amersham Int Plc Cationic complexes of technetium
US4935222A (en) * 1986-06-13 1990-06-19 University Of Cincinnati Procedure for isolating and purifying radioactive ligated rhenium pharmaceuticals and use thereof and kit
US4915933A (en) * 1986-06-26 1990-04-10 The University Of New Mexico Mixed complexes as shift and contrast reagents in NMR imaging and spectroscopy
US4714605A (en) * 1986-10-14 1987-12-22 E. R. Squibb & Sons, Inc. Technetium-99m labeled dioxime complexes
GB8711496D0 (en) * 1987-05-15 1987-06-17 Amersham Int Plc Tc-99m radiopharmaceuticals
GB8723438D0 (en) * 1987-10-06 1987-11-11 Amersham Int Plc Cationic complexes of technetium-99m
US4871836A (en) * 1987-10-13 1989-10-03 E. R. Squibb & Sons, Inc. Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes
DE68904905T2 (de) * 1988-03-09 1993-07-22 Cis Bio Int Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen.
US5002754A (en) * 1988-06-15 1991-03-26 University Of Cincinnati Technetium (III/II) imaging agents
GB8902362D0 (en) * 1989-02-03 1989-03-22 Amersham Int Plc Cationic complexes of technetium-99m
US5069900A (en) * 1989-08-28 1991-12-03 E. R. Squibb & Sons, Inc. Boronic acid adducts of technetium-99m dioxime-imine complexes
US5118797A (en) * 1989-08-28 1992-06-02 E. R. Squibb & Sons, Inc. Rhenium tris dioxime complexes
US6001979A (en) 1989-08-29 1999-12-14 Nycomed Amersham Plc Cores for technetium radiopharmaceuticals
US5855867A (en) * 1995-03-29 1999-01-05 The Curators Of The University Of Missouri Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same
JPH11504002A (ja) * 1995-03-29 1999-04-06 ザ キュアレイターズ オヴ ザ ユニヴァーシティー オヴ ミズーリー 診断医薬品及び治療医薬品としての使用のためのヒドロキシアルキルホスフィン化合物並びにその製造方法
US5804164A (en) * 1996-03-13 1998-09-08 Research Corporation Technologies, Inc. Water-soluble lipophilic contrast agents
JP3804453B2 (ja) 2001-01-19 2006-08-02 トヨタ紡織株式会社 リクライニング装置
WO2004096735A2 (en) * 2003-05-02 2004-11-11 Kamaluddin Abdur-Rashid Transfer hydrogenation processes and catalysts

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3902849A (en) * 1971-08-19 1975-09-02 Medi Physics Inc Radioisotope and radiopharmaceutical generators
HU167378B (de) * 1972-05-08 1975-09-27
US4031198A (en) * 1972-08-30 1977-06-21 Minnesota Mining And Manufacturing Company Technetium-labeled complexes, production and use thereof
US3928552A (en) * 1973-10-18 1975-12-23 Medi Physics Inc Hepato-biliary radiopharmaceutical comprising 2-mercaptoisobutyric acid chelating reduced technetium-99m
JPS5112609A (ja) * 1974-07-19 1976-01-31 Matsushita Electric Ind Co Ltd Dendokyokaitenichikenshutsusochi
US3992513A (en) * 1975-01-07 1976-11-16 Atomic Energy Of Canada Limited Labelled phospholipid material colloidially dispersed and sized to localize at preselected organs
US4088747A (en) * 1975-02-19 1978-05-09 Australian Atomic Energy Commission Phenolic amino-carboxylic acid radiopharmaceuticals
US4091088A (en) * 1975-02-19 1978-05-23 Australian Atomic Energy Commission Phenolic amino-carboxylic acid complexes for forming radiopharmaceuticals
US4017596A (en) * 1975-03-03 1977-04-12 Research Corporation Radiopharmaceutical chelates and method of external imaging
CA1070695A (en) * 1975-09-02 1980-01-29 Michael D. Loberg Iminodiacetic acid pharmaceutical
US4058593A (en) * 1976-01-28 1977-11-15 Minnesota Mining & Mfg Technetium-labeled bone scanning agents
JPS53148541A (en) * 1977-05-07 1978-12-25 Nihon Mediphysics Co Ltd Radioactive diagnostic agent labelled by technesiumm99m
US4256727A (en) * 1978-09-18 1981-03-17 The University Of Kentucky Research Foundation Synthesis and use of diagnostic radio-pharmaceuticals comprising radioactive isotopes of bromine with dyes
US4374821A (en) * 1982-06-28 1983-02-22 E. R. Squibb & Sons, Inc. Myocardial imaging agent and method

Also Published As

Publication number Publication date
JPH0662446B2 (ja) 1994-08-17
US4419339A (en) 1983-12-06
JPS5735523A (en) 1982-02-26
JPH03115231A (ja) 1991-05-16
EP0038756A2 (de) 1981-10-28
EP0038756A3 (en) 1982-03-03
HK81186A (en) 1986-11-07
US4387087A (en) 1983-06-07
JPH0349915B2 (de) 1991-07-31
IE51240B1 (en) 1986-11-12
IE810892L (en) 1981-10-18
CA1177091A (en) 1984-10-30
EP0038756B1 (de) 1985-10-16

Similar Documents

Publication Publication Date Title
DE3172648D1 (en) Cationic lipophilic complexes of 99m tc useful for myocardial and hepatobiliary imaging
JPS5660532A (en) Longgterm heart beat meter
ZA796975B (en) Alloys
DE3067728D1 (en) Measurements of free ligands
DE3064271D1 (en) Ceramic alloy
JPS5620981A (en) Drying of powder
GB2157563B (en) Pharmaceutical compositions containing iron complexes
GB8426845D0 (en) Complexes of technetium-99m
GB2113706B (en) Aersol antiperspirant composition
GB2110082B (en) Hair iron
JPS55164615A (en) Cosmetic substance manufacture
DE3372780D1 (en) Use of metal complexes of hydrazones as pigments
DE3375798D1 (en) Solid preparations of metal complex dyes
GB2041974B (en) Gold alloy
DE2965163D1 (en) Organosilicon compounds, their preparation and anti-tumor agents containing the same
JPS55103834A (en) Capsule type inspector
GB8817176D0 (en) Combined housing & applicator for cosmetic &c materials
DE3564861D1 (en) Imaging monochromator
JPS5643967A (en) Powder fireeextinguishing substance
JPS5654271A (en) Ceramic alloy
JPS5638399A (en) Powder detergent for garments
DE3050070D2 (en) Cosmetic preparation
JPS5616076A (en) Iron powder dryer
GB2045280B (en) Liquid phase sintering iron-carbon alloys
JPS57117802A (en) Hair iron

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: RESEARCH CORPORATION TECHNOLOGIES, INC. (N.D.GES.D

8328 Change in the person/name/address of the agent

Free format text: DERZEIT KEIN VERTRETER BESTELLT