DE3167198D1 - Process for the preparation of 2-thio penem derivatives and intermediates therefor - Google Patents

Process for the preparation of 2-thio penem derivatives and intermediates therefor

Info

Publication number
DE3167198D1
DE3167198D1 DE8181303650T DE3167198T DE3167198D1 DE 3167198 D1 DE3167198 D1 DE 3167198D1 DE 8181303650 T DE8181303650 T DE 8181303650T DE 3167198 T DE3167198 T DE 3167198T DE 3167198 D1 DE3167198 D1 DE 3167198D1
Authority
DE
Germany
Prior art keywords
thio
preparation
intermediates therefor
penem derivatives
penem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181303650T
Other languages
German (de)
English (en)
Inventor
Nigel John Perryman Broom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP81301683A external-priority patent/EP0041768B1/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE3167198D1 publication Critical patent/DE3167198D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8181303650T 1980-08-16 1981-08-11 Process for the preparation of 2-thio penem derivatives and intermediates therefor Expired DE3167198D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8026733 1980-08-16
EP81301683A EP0041768B1 (en) 1980-04-24 1981-04-15 Beta-lactam compounds, their preparation and use

Publications (1)

Publication Number Publication Date
DE3167198D1 true DE3167198D1 (en) 1984-12-20

Family

ID=26082013

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181303650T Expired DE3167198D1 (en) 1980-08-16 1981-08-11 Process for the preparation of 2-thio penem derivatives and intermediates therefor

Country Status (9)

Country Link
US (1) US4517124A (enExample)
EP (1) EP0046363B1 (enExample)
AU (1) AU7420281A (enExample)
DE (1) DE3167198D1 (enExample)
ES (1) ES8301237A1 (enExample)
GB (1) GB2083462B (enExample)
GR (1) GR74622B (enExample)
NZ (1) NZ198048A (enExample)
PT (1) PT73514B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
US4748162A (en) * 1982-03-01 1988-05-31 Merck & Co., Inc. 6-substituted-2-carbaminidoyl-pen-2-em-3-carboxylic acids
US4650794A (en) * 1982-04-29 1987-03-17 Merck & Co., Inc. 6-(1-hydroxyethyl)-2-carbamimidoyl-pen-2-em-3-carboxylic acids
KR900007181B1 (ko) * 1982-07-08 1990-09-29 훽스트 유케이 리미티드 펜엠 유도체의 제조방법
EP0110280B1 (en) * 1982-11-29 1994-10-12 Schering Corporation Process for the production of penem compounds
US4675317A (en) * 1983-01-25 1987-06-23 Merck & Co., Inc. 2-unsaturated alkylthio-pen-2-em-3-carboxylic acids
FI82471C (fi) * 1984-01-26 1991-03-11 Beecham Group Plc Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
US4806637A (en) * 1986-03-17 1989-02-21 Schering Corporation 6-(Hydroxyethyl)-2-(heterocyclylthio)-penem-3-carboxylates
US4876365A (en) * 1988-12-05 1989-10-24 Schering Corporation Intermediate compounds for preparing penems and carbapenems
US5541317A (en) * 1991-05-31 1996-07-30 Sankyo Company, Limited Azetidinone compounds useful in the preparation of carbapenem antibiotics and process for preparing carbapenem and penem compounds
HUT65301A (en) * 1992-09-09 1994-05-02 Sankyo Co New method for preparing of carbapenem- and penem-carbonacid-derivatives with antibacterial activity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
DE2965394D1 (en) * 1978-11-01 1983-06-16 Sanraku Ocean Co Process for producing antibiotic beta-lactam compounds
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
US4372965A (en) * 1979-10-15 1983-02-08 Merck & Co., Inc. 6-, 1- And 2-substituted-thio-1-carbadethiapen-2-em-3-carboxylic acid S-oxides
EP0051813B1 (en) * 1980-11-06 1986-07-30 Hoechst Uk Limited 7-oxo-4-thia-1-aza(3,2,0)heptane and 7-oxo-4-thia-1-aza(3,2,0)hept-2-ene derivatives
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems

Also Published As

Publication number Publication date
PT73514A (en) 1981-09-01
GB2083462B (en) 1984-05-02
GR74622B (enExample) 1984-06-29
US4517124A (en) 1985-05-14
PT73514B (en) 1982-10-28
EP0046363B1 (en) 1984-11-14
ES504764A0 (es) 1982-12-01
GB2083462A (en) 1982-03-24
EP0046363A1 (en) 1982-02-24
ES8301237A1 (es) 1982-12-01
AU7420281A (en) 1982-02-25
NZ198048A (en) 1985-04-30

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee