DE311148C - - Google Patents
Info
- Publication number
- DE311148C DE311148C DENDAT311148D DE311148DA DE311148C DE 311148 C DE311148 C DE 311148C DE NDAT311148 D DENDAT311148 D DE NDAT311148D DE 311148D A DE311148D A DE 311148DA DE 311148 C DE311148 C DE 311148C
- Authority
- DE
- Germany
- Prior art keywords
- cellulose
- weight
- tablets
- acetylsalicylic acid
- tabletted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229920002678 cellulose Polymers 0.000 claims description 11
- 239000001913 cellulose Substances 0.000 claims description 11
- 239000000835 fiber Substances 0.000 claims description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 229960001138 acetylsalicylic acid Drugs 0.000 description 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 235000011121 sodium hydroxide Nutrition 0.000 description 3
- VUKAUDKDFVSVFT-UHFFFAOYSA-N 2-[6-[4,5-bis(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dimethoxy-2-(methoxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol Chemical compound COC1C(OC)C(OC2C(C(O)C(OC)C(CO)O2)O)C(COC)OC1OC1C(COCC(C)O)OC(OC)C(OCC(C)O)C1OCC(C)O VUKAUDKDFVSVFT-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000249 desinfective Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drugs Drugs 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000031711 Cytophagaceae Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
KLASSE 30 h. GRUPPE 9.CLASS 30 h. GROUP 9.
und ähnliche Zwecke. s and similar purposes. s
Bekanntlich zerfallen komprimierte Arzneimitteltabletten vielfach nur sehr schwer. Diesem Übelstande suchte man bisher durch Zusatz von Stärke, gehärteter Gelatine (Patentschrift 228951) oder Amyloform (Patentschrift 250159) abzuhelfen.It is known that compressed pharmaceutical tablets often disintegrate only with great difficulty. Up to now this disadvantage has been sought through an addition of starch, hardened gelatin (patent specification 228951) or amyloform (patent specification 250159).
Es wurde nun die bemerkenswerte Beobachtung gemacht, daß man sehr leicht zerfallbare Tabletten auch mit Hilfe von feinverteilter Cellulose, die ihre Faserstruktur verloren hat und in den amorphen Zustand übergeführt ist, oder solchen Abkömmlingen derselben herstellen kann. Die Verwendung dieser Produkte hat den Vorteil, daß sie auch jetzt im Kriege in beliebigen Mengen zur Verfügung stehen und das denkbar billigste Material für solche Zwecke darstellen.The remarkable observation has now been made that one can easily disintegrate Tablets also with the help of finely divided cellulose, which has lost its fiber structure and has been converted into the amorphous state, or such descendants thereof can produce. The use of these products has the advantage that they do too are now available in any quantity during the war and the cheapest material imaginable for such purposes.
Durch die Patentschrift 141009, Kl. 30h, ist die Herstellung von Tabletten mit HilfeThrough the patent specification 141009, class 30h, is making tablets with the help
ao von Pflanzenfasern als Aufsaugemittel für Arzneistoffe und Desinfektionsmittel beschrieben. Die Fasern werden danach mit dem betreffenden Mittel getränkt und zusammengepreßt. Sie nehmen, in Wasser gebracht, ihr ursprüngliches Volumen wieder an, wobei sie das aufgesaugte Mittel abgeben (siehe Spalte 2, Zeile 43). Das Arznei- oder Desinfektionsmittel geht hierbei in Lösung, der Faserstoff, der sich nicht auflöst und nicht mit eingenommen werden kann, bleibt zurück. Nach vorliegendem Verfahren wird dagegen das in Wasser fein zerfallene Cellulosederivat zusammen mit dem Mittel eingenommen.ao of plant fibers as an absorbent for Medicinal substances and disinfectants described. The fibers are then with the concerned Medium soaked and compressed. They take, put in water, you original volume again, releasing the absorbed agent (see column 2, Line 43). The drug or disinfectant goes into solution, the fiber, which does not dissolve and cannot be taken with, remains behind. To In the present process, however, the cellulose derivative, which has been finely disintegrated in water, is combined taken with the remedy.
Nach dem Verfahren des genannten Patents werden die Faserstoffe hochprozentig mit dem betreffenden Mittel getränkt und nicht, wie bei vorliegendem Verfahren, eine gewisse Menge, wie etwa 20 Prozent des Cellulosederivats, dem Arzneimittel, wie z. B. Acetylsalicylsäure, zugesetzt, um nach dem Komprimieren ein gutes Auseinanderfallen der Tabletten' zu bewirken. According to the process of the patent mentioned, the fiber materials are highly concentrated with the soaked in the agent concerned and not, as in the present process, a certain amount, such as about 20 percent of the cellulose derivative, the drug, e.g. B. acetylsalicylic acid, added, to make the tablets fall apart well after compression.
1. ι Gewichtsteil Hydrocellulose (hergestellt nach dem Verfahren der Patentschrift 163316) wird mit 4 Gewichtsteilen Acetylsalicylsäure gemischt und die so erhaltene Mischung auf Tabletten verarbeitet.1. ι part by weight of hydrocellulose (manufactured according to the method of patent 163316) is acetylsalicylic acid with 4 parts by weight mixed and processed the mixture thus obtained on tablets.
2. ι Gewichtsteil Hydratcellulose in Form von Glanzstoffseidenabfällen (vorher mit kalter ioprozentiger Natronlauge behandelt, um die Struktur zu zerstören) wird mit 4 Gewichtsteilen Acetylsalicylsäure gemischt und tablettiert.2. ι part by weight of hydrate cellulose in the form of luster silk waste (previously with cold 10% caustic soda to destroy the structure) is treated with 4 parts by weight Acetylsalicylic acid mixed and tableted.
3. ι Gewichtsteil Acidcellulose (hergestellt durch Behandlung von Holzcellulose mit3. Part by weight of acid cellulose (produced by treating wood cellulose with
50 prozentiger Natronlauge in der Hitze bis zum Löslichwerden in verdünnter Natronlauge) wird mit 4 Gewichtsteilen Acetylsalicylsäure gemischt und tablettiert.50 percent caustic soda in the heat until it becomes soluble in dilute caustic soda) is mixed with 4 parts by weight of acetylsalicylic acid and tabletted.
In derselben Weise wirken totgemahlene Cellulose oder andere Abkömmlinge der Cellulose, wie Oxycellulose (siehe, Schwalbe, Die Chemie der Cellulose, Seite 228, Absatz 5, oder Ber. 33, 2237/1900), Oxycellulose nach CamiHe Kunz (Schwalbe, Die Chemie der Cellulose,Dead-milled cellulose or other derivatives of cellulose work in the same way, like oxycellulose (see, Schwalbe, The Chemistry of Cellulose, page 228, paragraph 5, or Ber. 33, 2237/1900), oxycellulose according to CamiHe Kunz (Schwalbe, The Chemistry of Cellulose,
Claims (1)
//Patent -Anspruch: ii
// Patent claim:
Publications (1)
Publication Number | Publication Date |
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DE311148C true DE311148C (en) |
Family
ID=564149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DENDAT311148D Active DE311148C (en) |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE311148C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1012432B (en) * | 1954-07-29 | 1957-07-18 | Josef Ellendorf & Co Dr Med | Process for the production of durable, phenol-containing molded preparations for the internal treatment of skin diseases, especially psoriasis |
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0
- DE DENDAT311148D patent/DE311148C/de active Active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1012432B (en) * | 1954-07-29 | 1957-07-18 | Josef Ellendorf & Co Dr Med | Process for the production of durable, phenol-containing molded preparations for the internal treatment of skin diseases, especially psoriasis |
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