DE3070735D1 - 4-aryloxy-3-phenylpiperidine derivatives, intermediates, a process for the preparation of such compounds and their use as medicaments - Google Patents

4-aryloxy-3-phenylpiperidine derivatives, intermediates, a process for the preparation of such compounds and their use as medicaments

Info

Publication number
DE3070735D1
DE3070735D1 DE8080104877T DE3070735T DE3070735D1 DE 3070735 D1 DE3070735 D1 DE 3070735D1 DE 8080104877 T DE8080104877 T DE 8080104877T DE 3070735 T DE3070735 T DE 3070735T DE 3070735 D1 DE3070735 D1 DE 3070735D1
Authority
DE
Germany
Prior art keywords
intermediates
compounds
aryloxy
preparation
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080104877T
Other languages
English (en)
Inventor
Solomon Samuel Klioze
Frederick Jacob Ehrgott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of DE3070735D1 publication Critical patent/DE3070735D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8080104877T 1980-02-19 1980-08-16 4-aryloxy-3-phenylpiperidine derivatives, intermediates, a process for the preparation of such compounds and their use as medicaments Expired DE3070735D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/117,532 US4312876A (en) 1979-02-23 1980-02-19 Antidepressive and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines

Publications (1)

Publication Number Publication Date
DE3070735D1 true DE3070735D1 (en) 1985-07-11

Family

ID=22373434

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080104877T Expired DE3070735D1 (en) 1980-02-19 1980-08-16 4-aryloxy-3-phenylpiperidine derivatives, intermediates, a process for the preparation of such compounds and their use as medicaments

Country Status (7)

Country Link
US (1) US4312876A (de)
EP (1) EP0034647B1 (de)
JP (1) JPS56118062A (de)
AT (1) ATE13669T1 (de)
CA (1) CA1160231A (de)
DE (1) DE3070735D1 (de)
ES (1) ES493888A0 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4387229A (en) * 1977-09-13 1983-06-07 Pfizer Inc. 3-[2-Hydroxy-4-(substituted)phenyl]azacycloalkanols and derivatives thereof
US4496732A (en) * 1983-03-14 1985-01-29 Hoechst-Roussel Pharmaceuticals Inc. Stereoselective reduction of 2- or 3-substituted 4-piperidones with sodium borohydride
GB8321157D0 (en) * 1983-08-05 1983-09-07 Fordonal Sa Piperidine derivatives
ZA9610741B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
EP1748984A1 (de) * 2004-05-12 2007-02-07 Pfizer Products Inc. Piperidinderivate als nk1- und nk3-antagonisten
US20070099237A1 (en) * 2005-10-31 2007-05-03 The Regents Of The University Of Michigan Reaction co-crystallization of molecular complexes or co-crystals

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3260723A (en) * 1963-08-27 1966-07-12 Parke Davis & Co 4-phenoxy piperidines; alpha4-phenoxy piperideines
US3542794A (en) * 1969-11-07 1970-11-24 Grover Cleveland Helsley 1-carbamoyl-4-phenoxypiperidines
DE2116316A1 (de) * 1970-04-08 1971-10-28 Sandoz Ag, Basel (Schweiz) Verfahren zur Herstellung neuer heterocyclischer Verbindungen
US3743645A (en) * 1970-10-19 1973-07-03 Robins Co Inc A H 1-substituted-4-phenoxypiperidines
US4132709A (en) * 1976-12-20 1979-01-02 Ayerst, Mckenna & Harrison, Ltd. [2]Benzopyrano[4,3-c]pyridine derivatives and process therefor
US4147872A (en) * 1977-09-13 1979-04-03 Pfizer Inc. 3-[2-Hydroxy-4-(substituted)-phenyl]azacycloalkanes and derivatives thereof as analgesic agents and intermediates therefor
US4216218A (en) * 1979-02-23 1980-08-05 American Hoechst Corporation Antidepressant and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines

Also Published As

Publication number Publication date
US4312876A (en) 1982-01-26
EP0034647A2 (de) 1981-09-02
JPS56118062A (en) 1981-09-16
JPH0243741B2 (de) 1990-10-01
ES8105711A1 (es) 1981-06-16
ATE13669T1 (de) 1985-06-15
EP0034647B1 (de) 1985-06-05
ES493888A0 (es) 1981-06-16
EP0034647A3 (en) 1982-03-03
CA1160231A (en) 1984-01-10

Similar Documents

Publication Publication Date Title
AU577928B2 (en) Labd-14-en-11-one derivatives
DE3063541D1 (en) Process for the preparation of 4'-epidaunorubicin, 3',4'-diepidaunorubicin, intermediates created thereby, as well as their use
ES525786A0 (es) Un procedimiento para preparar derivados de pirazolo (3,4-b) piridina
EP0014958B1 (en) Process for the preparation of 4,5-perfluoro-1,3-dioxolanes
DE3064183D1 (en) 4-aryloxy- and 4-arylthio-3-phenylpiperidine derivatives, a process for the preparation of such compounds and pharmaceutical compositions containing them
ES8800679A1 (es) Un procedimiento para preparar derivados de piperiliden-dihidrodibenzo-(a,d)-cicloheptenos y derivados aza
EP0006614A3 (en) Pyridyl- and imidazopyridyloxypropanolamines, process for preparing the same and pharmaceutical compositions containing the same
EP0033156A3 (en) 1-phenyl-2-cyclohexene-1-alkylamine derivatives, intermediates and process for their preparation, medicines containing them and their use as pharmaceutically active compounds
DE3070735D1 (en) 4-aryloxy-3-phenylpiperidine derivatives, intermediates, a process for the preparation of such compounds and their use as medicaments
DE2961613D1 (en) Halogenated 1-azolyl-1-fluorophenoxy butanes, process for their preparation, fungicides comprising them as well as their use as fungicides
DE3068620D1 (en) Hydroxybutyl-imidazole derivatives, process for their preparation, intermediates necessary for the latter and their use as fungicides
DE3167672D1 (en) Substituted phenoxy-aminopropanol derivatives, intermediates and process for their preparation and medicament containing them
ES8304548A1 (es) "procedimiento de preparacion de derivados de fenetanolamina".
JPS57123164A (en) Hydroxyphenyltetrahydropyridine novel derivatives and their salts, manufacture and intermediates, use as drug and composition containing same
AU553874B2 (en) Thiazaspirane derivatives
BR9101973A (pt) Compostos quimicos,processo para a sua preparacao e composicoes farmaceutica e terapeutica
DE3469358D1 (en) Novel 3-(4'-aminobutylamino)-propylamino-bleomycin derivatives, a process for their preparation and their use as medicaments
DE3160074D1 (en) 2,3-dihydrobenzofurans, process for their preparation and pharmaceutical compositions containing them
DE3573257D1 (en) (6,11-dihydro-11-oxodibenz(bm,e)oxepinyl)pentanols, a process and intermediates for their preparation and their use as medicaments
JO1652B1 (en) New compounds for local anesthesia and a way to prepare them

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee