DE3069832D1 - Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them - Google Patents

Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them

Info

Publication number
DE3069832D1
DE3069832D1 DE8080105492T DE3069832T DE3069832D1 DE 3069832 D1 DE3069832 D1 DE 3069832D1 DE 8080105492 T DE8080105492 T DE 8080105492T DE 3069832 T DE3069832 T DE 3069832T DE 3069832 D1 DE3069832 D1 DE 3069832D1
Authority
DE
Germany
Prior art keywords
preparation
pharmaceutical compositions
cephalosporin analogs
acylated cephalosporin
acylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080105492T
Other languages
English (en)
Inventor
Tadashi Hirata
Takehiro Ogasa
Shigeru Kobayashi
Kiyoshi Sato
Chikahiro Urakawa
Akira Sato
Yukio Hashimoto
Seigo Takasawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP11672079A external-priority patent/JPS5640683A/ja
Priority claimed from JP13698779A external-priority patent/JPS5661378A/ja
Priority claimed from JP2203580A external-priority patent/JPS56118084A/ja
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of DE3069832D1 publication Critical patent/DE3069832D1/de
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D463/00Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16Nitrogen atoms
    • C07D463/18Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568Four-membered rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
DE8080105492T 1979-09-13 1980-09-12 Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them Expired DE3069832D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11672079A JPS5640683A (en) 1979-09-13 1979-09-13 Cephalosporin analogue
JP13698779A JPS5661378A (en) 1979-10-25 1979-10-25 Optically active cephalosporin analog
JP2203580A JPS56118084A (en) 1980-02-23 1980-02-23 Optically active cephalosporin analogue

Publications (1)

Publication Number Publication Date
DE3069832D1 true DE3069832D1 (en) 1985-01-31

Family

ID=27283683

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080105492T Expired DE3069832D1 (en) 1979-09-13 1980-09-12 Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them

Country Status (6)

Country Link
EP (1) EP0025602B1 (de)
CA (1) CA1178957A (de)
DE (1) DE3069832D1 (de)
DK (1) DK389080A (de)
ES (1) ES8200689A1 (de)
NO (1) NO802713L (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
EP0061765B1 (de) * 1981-03-30 1985-08-28 E.R. SQUIBB & SONS, INC. Beta-Laktame
EP0082501A1 (de) * 1981-12-18 1983-06-29 Kyowa Hakko Kogyo Co., Ltd Beta-Lactam-Verbindung und sie enthaltende pharmazeutische Zusammensetzung
EP0112481A1 (de) * 1982-11-12 1984-07-04 Kyowa Hakko Kogyo Co., Ltd Beta-Lactam-Verbindung
DE3803169A1 (de) 1988-02-03 1989-08-17 Bayer Ag Ss-lactam-antibiotika, verfahren zu ihrer herstellung und ihre verwendung als und in arzneimitteln
US5099015A (en) * 1991-01-10 1992-03-24 Eli Lilly And Company Trifluoromethyl 1-carba(1-dethia)cephems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4012383A (en) * 1975-01-02 1977-03-15 Bristol-Myers Company Δ2,3 -1,4-morpholine-2-carboxylic acids and derivatives thereof useful in preparation of antibacteria agents
US4089956A (en) * 1976-09-08 1978-05-16 Smithkline Corporation 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof
JPS54128591A (en) * 1978-03-25 1979-10-05 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog

Also Published As

Publication number Publication date
EP0025602A1 (de) 1981-03-25
NO802713L (no) 1981-03-16
ES495035A0 (es) 1981-11-16
EP0025602B1 (de) 1984-12-19
CA1178957A (en) 1984-12-04
DK389080A (da) 1981-03-14
ES8200689A1 (es) 1981-11-16

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee