DE306979C - - Google Patents
Info
- Publication number
- DE306979C DE306979C DENDAT306979D DE306979DA DE306979C DE 306979 C DE306979 C DE 306979C DE NDAT306979 D DENDAT306979 D DE NDAT306979D DE 306979D A DE306979D A DE 306979DA DE 306979 C DE306979 C DE 306979C
- Authority
- DE
- Germany
- Prior art keywords
- tannic acid
- lime
- basic
- sparingly soluble
- dilute acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000001263 FEMA 3042 Substances 0.000 claims description 9
- 229940033123 Tannic Acid Drugs 0.000 claims description 9
- LRBQNJMCXXYXIU-NRMVVENXSA-N Tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 claims description 9
- 235000015523 tannic acid Nutrition 0.000 claims description 9
- 229920002258 tannic acid Polymers 0.000 claims description 9
- 235000008733 Citrus aurantifolia Nutrition 0.000 claims description 7
- 235000015450 Tilia cordata Nutrition 0.000 claims description 7
- 235000011941 Tilia x europaea Nutrition 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 7
- 239000011575 calcium Substances 0.000 claims description 7
- 239000004571 lime Substances 0.000 claims description 7
- 150000007513 acids Chemical class 0.000 claims description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 208000001848 Dysentery Diseases 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001264 neutralization Effects 0.000 description 2
- YXFVVABEGXRONW-UHFFFAOYSA-N toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 2
- 210000000416 Exudates and Transudates Anatomy 0.000 description 1
- 210000004051 Gastric Juice Anatomy 0.000 description 1
- 210000000936 Intestines Anatomy 0.000 description 1
- VXMKYRQZQXVKGB-CWWHNZPOSA-N Tannin Chemical compound O([C@H]1[C@H]([C@@H]2OC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)O[C@H]([C@H]2O)O1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 VXMKYRQZQXVKGB-CWWHNZPOSA-N 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000249 desinfective Effects 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N o-xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organs Anatomy 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000019608 salt taste sensations Nutrition 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 230000000391 smoking Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 230000035917 taste Effects 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
Es ist seit langer Zeit bekannt, daß bei der Behandlung einiger Formen der Dysenterie Tanninpräparate sich gut bewährt haben. Ihre Wirkung beruht wahrscheinlich auf der zum Teil gerbenden, zum Teil desinfizierenden Eigenschaft der Gerbsäure.It has long been known to be useful in treating some forms of dysentery Tannin preparations have proven themselves well. Their effect is probably based on the for Partly tanning, partly disinfecting properties of tannic acid.
Neuerdings hat sich nun gezeigt, daß dem Kalk und seinen Salzen durch ihre exudathemmende und die Gefäße verengernde Eigenschaft eine in gewissem Sinne spezifische Wirkung bei der Behandlung der Dysenterie zukommt. Recently it has now been shown that lime and its salts are exudate-inhibiting and the vasoconstricting property has a specific effect in a certain sense in the treatment of dysentery.
Eine ideale Behandlung würde danach durch Anwendung einer Verbindung von Kalk mitAn ideal treatment would then be by applying a compound of lime with
i§ Gerbsäure erzielt werden können. Es sind die nach der Theorie möglichen zwei Salze schon dargestellt und ι in der Literatur beschrieben worden:i§ tannic acid can be achieved. There are the two salts possible according to the theory have already been presented and described in the literature been:
das neutrale gerbsaure Calcium Ca (C14 H9 O9) 2, das basische gerbsaure Calcium Ca (O H) (C14H9O9) (vgl. G'melin-Kraut, Handb. der Organ. Chemie 4. Aufl., Bd. IV, 1. Abt. [1862], S. 891; Mercks Index 3. Aufl. 1910, S. 69 unter Calcium tannicum).the neutral tannic acid calcium Ca (C 14 H 9 O 9 ) 2, the basic tannic acid calcium Ca (OH) (C 14 H 9 O 9 ) (cf. G'melin-Kraut, Handb. der Organ. Chemie 4th ed. , Vol. IV, 1. Abt. [1862], p. 891; Mercks Index, 3rd ed. 1910, p. 69 under Calcium tannicum).
Das neutrale Salz ist leicht löslich in verdünnten Säuren und besitzt einen sehr unangenehmen Geschmack. Das basische Salz schmeckt besser, löst sich aber frisch gefällt oder bei niedriger Temperatur getrocknet ebenfalls in verdünnten Säuren leicht auf.The neutral salt is easily soluble in dilute acids and is very unpleasant Taste. The basic salt tastes better, but dissolves when fresh or also lightly dried at low temperature in dilute acids.
Die zweckmäßigste Behandlung der Dysenterie würde aber durch ein Präparat erfolgen können, das im Magensaft schwer löslich, im Darm auf seiner ganzen Länge Kalk- und Gerbsäure abgeben würde.The most expedient treatment of dysentery would, however, be by means of a preparation can, which is sparingly soluble in gastric juice, lime and tannic acid in the intestine along its entire length would give away.
Es wurde nun gefunden, daß das basische gerbsaure Kalksalz auch in verdünnten Säuren schwer löslich wird, wenn es längere Zeit für sich auf höhere Temperaturen erhitzt wird. Es entspricht daher ein nach dem vorliegenden Verfahren hergestelltes Präparat den genannten Anforderungen. ■It has now been found that the basic tannic acid lime salt can also be used in dilute acids becomes sparingly soluble if it is heated to higher temperatures for a long time. A preparation produced according to the present process therefore corresponds to the mentioned requirements. ■
, ■ ■ Beispiel:, ■ ■ Example:
Die nach bekannten Verfahren darstellbare basisch gerbsaure Kalkverbindung wird nach dem Trocknen an der Luft etwa 6 Stunden bei etwa 140 bis 150° C, d. h. so lange erhitzt, bis sie in Säure schwer löslich geworden ist. iThe basic tannic acid lime compound which can be prepared by known processes is used according to air drying for about 6 hours at about 140 to 150 ° C; d. H. heated for so long until it has become sparingly soluble in acid. i
Zeitdauer, und Wärmegrade können in weiten Grenzen abgeändert werden.Length of time and degrees of warmth can vary widely Boundaries can be changed.
Vorstehende Angaben entsprechen einem technisch zweckmäßigen Verfahren.The above information corresponds to a technically appropriate procedure.
Diese gerbsaure Kalkverbindung ist ein graubraunes Pulver. Es ist in Wasser unlöslich und in verdünnten Säuren schwer löslich, in Alkohol und Aceton sowie in Äther, Chloroform, Petroläther, Benzol, Toluol und Xylol in der Kälte und Wärme so gut wie unlöslich.This tannic acid lime compound is a gray-brown powder. It is insoluble in water and sparingly soluble in dilute acids, in alcohol and acetone as well as in ether, chloroform, Petroleum ether, benzene, toluene and xylene are as good as insoluble in the cold and heat.
Analyse: 1,999 g Substanz geben nach dem Abrauchen mit SchwefelsäureAnalysis: 1.999 g of substance give after smoking with sulfuric acid
= 0,7016 g CaSO4,
= 14,4 Prozent Ca O;= 0.7016 g CaSO 4 ,
= 14.4 percent Ca O;
berechnet für:calculated for:
Ca (OH) C14 H9 O4 = 14,8 Prozent.Ca (OH) C 14 H 9 O 4 = 14.8 percent.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE306979C true DE306979C (en) |
Family
ID=560358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT306979D Active DE306979C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE306979C (en) |
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0
- DE DENDAT306979D patent/DE306979C/de active Active
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