DE3065362D1 - Phenoxypropyl amine derivatives, process for their preparation, and pharmaceutical compositions containing them - Google Patents

Phenoxypropyl amine derivatives, process for their preparation, and pharmaceutical compositions containing them

Info

Publication number
DE3065362D1
DE3065362D1 DE8080103742T DE3065362T DE3065362D1 DE 3065362 D1 DE3065362 D1 DE 3065362D1 DE 8080103742 T DE8080103742 T DE 8080103742T DE 3065362 T DE3065362 T DE 3065362T DE 3065362 D1 DE3065362 D1 DE 3065362D1
Authority
DE
Germany
Prior art keywords
phenoxypropyl
preparation
pharmaceutical compositions
compositions containing
amine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080103742T
Other languages
English (en)
Inventor
Kenyu Shibata
Toshihisa Itaya
Nobuaki Yamakoshi
Shigeru Kurata
Naoyuki Koizumi
Masaaki Tarutani
Hideki Sakuma
Kunihiro Konishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP54083426A external-priority patent/JPS609750B2/ja
Priority claimed from JP1908880A external-priority patent/JPS56115750A/ja
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Application granted granted Critical
Publication of DE3065362D1 publication Critical patent/DE3065362D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8080103742T 1979-07-03 1980-07-01 Phenoxypropyl amine derivatives, process for their preparation, and pharmaceutical compositions containing them Expired DE3065362D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP54083426A JPS609750B2 (ja) 1979-07-03 1979-07-03 新規なｎ−置換フエノキシプロピルアミド化合物
JP1908880A JPS56115750A (en) 1980-02-20 1980-02-20 Substituted phenoxypropylamine compound

Publications (1)

Publication Number Publication Date
DE3065362D1 true DE3065362D1 (en) 1983-11-24

Family

ID=26355891

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080103742T Expired DE3065362D1 (en) 1979-07-03 1980-07-01 Phenoxypropyl amine derivatives, process for their preparation, and pharmaceutical compositions containing them

Country Status (6)

Country Link
US (1) US4293557A (de)
EP (1) EP0024510B1 (de)
DE (1) DE3065362D1 (de)
HK (1) HK95386A (de)
MY (1) MY8700563A (de)
SG (1) SG75886G (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR228941A1 (es) * 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative
GR77847B (de) * 1981-12-14 1984-09-25 American Home Prod
EP0102157B1 (de) * 1982-07-30 1986-09-03 Smith Kline & French Laboratories Limited Aminopyrimidinone und ihre Herstellung
IL69392A (en) * 1982-08-13 1987-01-30 Sanofi Sa N-oxide nicotinamide derivatives,their preparation and pharmaceutical compositions containing them
FR2531704B1 (fr) * 1982-08-13 1985-08-09 Sanofi Sa Amides d'acides (hetero)aromatiques n-substitues, leurs sels, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2544717B1 (fr) * 1983-04-22 1986-03-28 Sanofi Sa Nicotinamide l-oxyde n-substitue, ses sels, procede pour leur preparation et compositions pharmaceutiques en contenant
US4837316A (en) * 1985-08-29 1989-06-06 Fujirebio Kabushiki Kaisha Alkylamide derivatives with H2 -receptor antagonistic and cytoprotective action
JPH0639466B2 (ja) * 1987-08-03 1994-05-25 杏林製薬株式会社 ウレア誘導体
US4988828A (en) * 1987-11-27 1991-01-29 Fujirebio Kabushiki Kaisha Phenoxypropyl derivatives
US5112866A (en) * 1988-09-06 1992-05-12 Ortho Pharmaceutical Corporation Ethanesulfonamide derivatives
US4874771A (en) * 1988-09-06 1989-10-17 Ortho Pharmaceutical Corporation Ethanesulfonamide derivatives
JPH03148217A (ja) * 1989-11-02 1991-06-25 Terumo Corp フエノキシプロピルアミン誘導体またはその塩ならびにこれらを含有する抗潰瘍剤
JPH0692948A (ja) * 1992-03-04 1994-04-05 Snow Brand Milk Prod Co Ltd 新規なアセタミド誘導体及びその用途
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
US5312990A (en) * 1993-05-28 1994-05-17 Hoechst Celanese Corporation Di-amino compounds
BG61302B1 (bg) * 1993-09-30 1997-05-30 Нихфи Ад n-(3-(3-(1-пиперидинилметил)фенокси)пропил)хидроксиацетамид 1,2,3-пропентрикарбоксилат бисмут /3+/комплекс и метод за получаването му
CA2349575A1 (en) * 1998-11-17 2000-05-25 Nitromed, Inc. Nitrosated and nitrosylated h2 receptor antagonist compounds, compositions and methods of use
EP1579862A1 (de) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Verwendung von PDE III Ihibitoren zur Reduktion der Herzgrösse in an Herzversagen leidenden Säugern
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
AU2006228957A1 (en) * 2005-04-01 2006-10-05 Methylgene Inc. Inhibitors of histone deacetylase
EP1920785A1 (de) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Pimobendan-Cyclodextrin Komplex enthaltendes flüssiges Präparat
CN103058958A (zh) * 2011-10-22 2013-04-24 杭州福斯特药业有限公司 一种罗沙替丁醋酸酯盐酸盐的合成方法
ES2924478T3 (es) 2012-03-15 2022-10-07 Boehringer Ingelheim Vetmedica Gmbh Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos
CN113181110A (zh) 2013-07-19 2021-07-30 勃林格殷格翰动物保健有限公司 含有防腐的醚化的环糊精衍生物的液体水性药物组合物
WO2015082389A1 (en) 2013-12-04 2015-06-11 Boehringer Ingelheim Vetmedica Gmbh Improved pharmaceutical compositions of pimobendan
CN104311510A (zh) * 2014-09-18 2015-01-28 哈药集团三精制药股份有限公司 一种盐酸罗沙替丁醋酸酯关键中间体的制备方法
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN106883197B (zh) * 2017-02-10 2019-01-25 哈药集团三精明水药业有限公司 一种盐酸罗沙替丁醋酸酯制备方法
CN107857743B (zh) * 2017-10-20 2020-08-18 北京四环制药有限公司 一种制备盐酸罗沙替丁醋酸酯及中间体的方法
EP4196793A1 (de) 2020-08-11 2023-06-21 Université de Strasbourg Auf lebermakrophagen abzielende h2-blocker zur prävention und behandlung von lebererkrankungen und krebs

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1338169A (en) 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US3856812A (en) * 1971-03-15 1974-12-24 Merck Patent Gmbh Pyrrole phenoxyacetic acid derivatives
US3996279A (en) * 1973-01-02 1976-12-07 Gerot-Pharmazeutika Dr. Walter Otto K.G. Novel 2-amino methyl-4,6-dihalogenphenol derivatives and methods for the preparation thereof
GB1466130A (en) * 1974-12-06 1977-03-02 Pfizer Ltd Adamantane derivatives
US4134983A (en) * 1975-03-03 1979-01-16 Merck & Co., Inc. 3-amino-2-or-propoxyaryl substituted imidazoles
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
IE46886B1 (en) 1977-05-17 1983-10-19 Allen & Hanburys Ltd Aminoalkyl-benzene derivatives
US4156079A (en) * 1978-06-19 1979-05-22 E. R. Squibb & Sons, Inc. Substituted amides having antiinflammatory activity
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative

Also Published As

Publication number Publication date
EP0024510A1 (de) 1981-03-11
US4293557A (en) 1981-10-06
HK95386A (en) 1986-12-19
SG75886G (en) 1987-02-27
MY8700563A (en) 1987-12-31
EP0024510B1 (de) 1983-10-19

Similar Documents

Publication Publication Date Title
DE3065362D1 (en) Phenoxypropyl amine derivatives, process for their preparation, and pharmaceutical compositions containing them
DE3064173D1 (en) Novel 20-0-acylmaytansinoids, process for their preparation and pharmaceutical compositions containing them
DE3068020D1 (en) Aminoalkylbenzene derivatives, process for their preparation and pharmaceutical compositions
DE3065949D1 (en) Naphthyridine derivatives, processes for their preparation and pharmaceutical compositions containing them
DE2860900D1 (en) Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
IL59915A (en) Amides of acyl-carnitines,process for their preparation and pharmaceutical compositions containing them
DE2963573D1 (en) Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them
DE2861361D1 (en) 1-n-acylated-4-o-glycosyl-6-o-glycosyl-1,3-diaminocyclitol derivatives, process for their preparation and pharmaceutical compositions containing them
DE3062884D1 (en) Spiro-hydantoin derivatives, process for their preparation and pharmaceutical compositions thereof
DE3161238D1 (en) 20-deoxyrosaramicin derivatives, process for their preparation and pharmaceutical compositions containing them
DE2964209D1 (en) Spiro-furanohydantoin derivatives, process for their preparation and pharmaceutical compositions containing them
DE2962112D1 (en) Alkanolamine derivatives, process for their preparation and pharmaceutical compositions containing them
DE3061438D1 (en) Quinoline compounds, process for their preparation, and pharmaceutical compositions
IL69735A (en) 1-phenyl-1-aminoalkyl-cyclobutane derivatives,process for their preparation and pharmaceutical compositions containing them
DE3060894D1 (en) Benzimidazolone derivatives, process for their preparation and pharmaceutical compositions containing them
DE2860777D1 (en) N-substituted 2-hydrazono-propionic acid derivatives, process for their preparation and pharmaceutical compositions containing them
IL60408A (en) Sulfur-containing isoquinoline derivatives,process for the preparation thereof and pharmaceutical compositions containing them
DE3060079D1 (en) Spiro-quinolylhydantoins, process for their preparation and pharmaceutical compositions thereof
DE3062972D1 (en) Pyridazopyridazine derivatives, processes for their preparation and pharmaceutical compositions containing these pyridazopyridazine derivatives
DE3062531D1 (en) Pyrrolidine derivatives, processes for their preparation and pharmaceutical compositions containing them
DE2861767D1 (en) Cephalosprin derivatives, process for their preparation and pharmaceutical compositions containing them
IL64123A (en) Biphenylyloxypropoxypyrimidine derivatives,process for their preparation and pharmaceutical compositions containing them
EP0018077A3 (en) Phenylmorphans, processes for their preparation, pharmaceutical compositions containing them, and 4-phenyl-tetrahydro-pyridines
ZA807795B (en) N-substituted a-amido ,process for making them and pharmaceutical compositions containing them
DE3069832D1 (en) Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them

Legal Events

Date Code Title Description
V448 Application of spc

Free format text: PRODUCT NAME: ROXATIDINACETAT; REGISTRATION NO/DATE: 9808.01.00, 19890822

Spc suppl protection certif: 193 75 024

Filing date: 19930519

V457 Spc granted

Free format text: PRODUCT NAME: ROXATIDINACETAT; REGISTRATION NO/DATE: 9808.01.00, 19890822

Spc suppl protection certif: 193 75 024

Filing date: 19930519

V464 Spc expired

Free format text: PRODUCT NAME: ROXATIDINACETAT; REGISTRATION NO/DATE: 9808.01.00, 19890822

Spc suppl protection certif: 193 75 024

Filing date: 19930519